Zinc supplementation for improving pregnancy and infant outcome

Mori, Rintaro; Ota, Erika; Middleton, Philippa; Tobe‐Gai, Ruoyan; Mahomed, Kassam; Bhutta, Zulfiqar Ahmed

doi:10.1002/14651858.cd000230.pub4

Cited by 63 publications

(52 citation statements)

References 77 publications

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“…This was supported by a recent meta-analysis which found that calcium supplementation during pregnancy was associated with decreased risk of pre-eclampsia by 52%-55% and gestational hypertension by 35% in developing countries. Furthermore they observed that calcium supplementation during pregnancy was associated with a significant fall in neonatal mortality and risk of pre-term births by 24% 33 .…”

Section: Discussionmentioning

confidence: 99%

Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study

Kumar¹,

Singh²

2018

OBGYN

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Objectives: Assess relationship between maternal serum calcium levels, severity of disease and overall perinatal and maternal outcome in women with hypertensive disorders of pregnancy. Methods: Present prospective cross sectional study was conducted in the Obstetrics and Gynaecology department of rural tertiary care centre of Northern India after proper Institution ethical committee approval and informed written consent from the participants over a period of seven months (October 2016-May 2017. A total of 110 childbearing women admitted at ≥34 weeks of gestation were divided into three groups; Gestational hypertension (n=35), Preeclampsia (n=49) and Eclampsia (n=26). Maternal serum calcium levels and its correlation with severity of disease and overall maternal and perinatal outcome were assessed in each group. Results: Of 110 childbearing women, cases with gestational hypertension had mean serum calcium 8.83 ± 0.55 mg/dl, in pre-eclampsia 8.55 ± 0.89 mg/dl and in eclampsia group 8.41 ± 0.76 mg/dl. Of total 66 term births, 31(88.57%) occurred in gestational hypertension group, 26(53.06%) in pre-eclampsia and 8(30.77%) in eclampsia group. Maximum maternal and perinatal morbidity and mortalities were observed in women with eclampsia having minimum serum calcium levels followed by pre-eclampsia and least in women with gestational hypertension having near normal serum calcium levels. Conclusion: Significant correlation was observed between maternal serum calcium and severity of hypertensive disorder of pregnancy, adverse perinatal and maternal outcome.Keywords: Blood pressure, calcium, hypertension, pregnancy, perinatal.Hypertension during pregnancy with or without proteinuria is one of the leading causes of maternal and perinatal morbidity and mortality all over the world 1-4 , accounting for more than 40,000 maternal deaths annually 5 . Worldwide hypertensive Disorder of Pregnancy (HDP) affects around 10% of all pregnancies with pre-eclampsia and eclampsia together accounting for 10-15% of all direct maternal deaths 1 and major burden of perinatal morbidity and mortality 6-9 . There is worldwide regional variation in distribution of maternal deaths due to HDP with 16.1% occurring in developed countries, 9.1% in Africa, 9.1% in Asia, and around 25.7% in Latin America and the Caribbean 2 .Till date the only proven way to prevent development as well as severity of HDP is calcium supplementation 1 .Calcium supplementation during pregnancy is known to decrease incidence as well as severity of gestational hypertension, pre-eclampsia, eclampsia and also neonatal RESEARCH ARTICLE

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Section: Discussionmentioning

confidence: 99%

Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study

Kumar¹,

Singh²

2018

OBGYN

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“…Complementary medicines, such as trace element supplements, can be assumed as proper candidates for investigation in chronic psychiatric disorders due to lower risk of side-effects as well as better acceptance among people (35). Zinc is an essential trace element in the body (6,7), which is required for development of the brain and also for its function (9)(10)(11). So far, positive effects of supplemental Zn on depression (15,36,37), OCD (6), ADHD (14,31), and AD (11) have been reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Zinc is also introduced as an antioxidant element (5,8). It is required for development of the brain and also for its function; Zn deficiency can cause neuronal damage (9)(10)(11). While Zn deficiency is reported in patients with Alzheimer's Disease (AD), cognitive improvement has also been demonstrated in these patients after supplementation with Zn in some preliminary studies (11).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial

Mortazavi

Farzin

Zarhghami

et al. 2015

Iran J Psychiatry Behav Sci

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Background: Zinc can modulate fast-excitatory transmission, facilitate the release of amino butyric acid and potentiate nicotinic acetylcholine receptors. There are also emerging evidences discussing the implication of these neurotransmitters in pathophysiology of schizophrenia. Objectives: The purpose of this study was to evaluate the efficacy of Zn sulfate as an add-on therapy in the treatment of schizophrenia in a 6-week, double-blind and placebo-controlled trial. Patients and Methods: Eligible participants were 30 inpatients with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Patients were randomly allocated into two equal groups; one group of patients received risperidone 6 mg/day plus capsules of Zn sulfate (each containing 50 mg elemental Zn) three times a day and another group received risperidone 6 mg/day plus placebo. The Positive and Negative Syndrome Scale (PANSS) was applied to assess the psychotic symptoms and aggression risk at baseline, week 2, 4, and 6 of the study. Results:The results of this study showed that both protocols significantly decreased the scores on all subscales of the PANSS and supplemental aggression risk subscale as well as PANSS total score over the study. However, this improvement was significantly higher in Zn sulfate receiving group compared to the placebo group. No major clinical side-effects were detected. Conclusions: It may be concluded that Zn is an effective adjuvant agent in the management of patients with schizophrenia.

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“…Las revisiones sistemáticas que evaluaron los efectos de la administración de un suplemento de zinc con cantidades que variaron de 15 a 60mg, mostraron que el único efecto protector atribuible al mismo es disminuir el número de nacimientos pretérmino y no se demostró que logre disminuir la prevalencia de bajo peso al nacer. Los beneficios se observaron en estudios que provenían de paí-ses subdesarrollados y de subgrupos de bajo nivel socioeconómico, por lo cual posiblemente se consiguiera un efecto similar o aun mayor en la disminución de los nacimientos pretérmino si se mejorase la calidad nutricional de la alimentación en estas poblaciones de gestantes 44,45 . La vitamina A es un nutriente habitualmente marginal y se ha comprobado que la suplementación puede ser beneficiosa en áreas donde la deficiencia tenga una elevada prevalencia y sea de carácter endémico, como sucede en algunas zonas de Asia.…”

Section: Vitaminas Y Mineralesunclassified

Estado actual del conocimiento sobre el cuidado nutricional de la mujer embarazada

Barretto

Mackinnon

Poy

et al. 2014

Rev Esp Nutr Hum Diet

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El embarazo implica una importante actividad anabólica que determina un aumento de las necesidades nutricionales con relación al periodo preconcepcional. El presente trabajo se propone revisar los conocimientos actuales sobre las necesidades energéticas, de macro y micronutrientes durante la gestación, así como también los lineamientos para abordar los trastornos gastrointestinales frecuentes durante el embarazo, la problemática de pica y la valoración antropométrica para asegurar una ganancia de peso óptima. La mayoría de los nutrientes requeridos por la gestación pueden ser proporcionados por una alimentación completa y balanceada. Actualmente la evidencia científica demuestra que la suplementación rutinaria con hierro y ácido fólico durante la gestación, constituye una práctica que previene la anemia ferropénica, los trastornos del tubo neural y los nacimientos pretérmino. La suplementación intermitente puede ser una alternativa igualmente eficaz. Cuando la alimentación no garantiza un aporte adecuado también pueden ser necesarios suplementos de yodo, vitamina B 12 y vitamina D. La valoración antropométrica mediante el patrón de ganancia de peso debiera estar presente en cada consulta del control prenatal para evitar complicaciones maternas y fetales. En situaciones donde el peso materno no se puede valorar, la circunferencia muscular del brazo es una alternativa posible para realizar una evaluación general ya que se correlaciona de manera adecuada con el aumento de peso materno. Las mediciones de los pliegues cutáneos del bíceps, tríceps y subescapular constituyen otra alternativa que resulta de utilidad para evaluar los depósitos grasos y su localización, en forma complementaria a la ganancia de peso corporal. PALABRAS CLAVEEmbarazo R E S U M E NEstado actual del conocimiento sobre el cuidado nutricional de la mujer embarazada R

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Zinc supplementation for improving pregnancy and infant outcome

Cited by 63 publications

References 77 publications

Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study

Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study

Efficacy of Zinc Sulfate as an Add-on Therapy to Risperidone versus Risperidone Alone in Patients With Schizophrenia: A Double-Blind Randomized Placebo-Controlled Trial

Estado actual del conocimiento sobre el cuidado nutricional de la mujer embarazada

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