Zinc supplementation could modulate T cell to maintain interleukin-2 level in seropositive contact of leprosy patients

Rahfiludin, M. Zen; Wirjatmadi, Bambang; Agusni, Indropo; Dahlan, Yoes Priatna

doi:10.13181/mji.v20i3.454

Cited by 7 publications

(7 citation statements)

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“…It must be noted that participants of included studies in our meta-analysis on the effect of Zn treatment on IL-2 level were from people with a low concentration of serum/plasma Zn. Moreover, other ex vivo studies revealed that Zn supplementation had increasing effect on IL-2 production in Zn-deficient subjects (47,51) . Therefore, it seems that Zn supplementation corrected the low level of IL-2 as an antiinflammatory agent.…”

Section: Discussionmentioning

confidence: 97%

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

et al. 2021

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Chronic inflammation has been considered as the main cause of chronic diseases. Zn has anti-inflammatory effects by decreasing the expression of inflammatory markers. The present systematic review and meta-analysis study aims to evaluate the impact of Zn supplementation on inflammation. Pubmed (Medline), Scopus, Web of Science, and Embase databases were searched up to December 10th, 2020. Randomized placebo-controlled trials have investigated the effects of Zn supplementation on serum/plasma levels of inflammatory cytokines in >15 years’ subjects were included. A pooled meta-analysis was performed using a random-effect model. Sensitivity analysis was performed to determine the robustness of the observed effect sizes. Potential causes of heterogeneity were determined using subgroup analyses. The relationship between effect size and co-variables was explored using meta-regression. In the cases of the presence of publication bias, trim and fill analysis was carried out. Cochrane Collaboration’s tool was used for assessing the quality of the included studies. A total of 12 studies was included in meta-analysis. Zn could decrease IL-6 levels (SMD= -0.76 pg/ml; 95% CI: -1.28, -0.24; P= 0.004). There was no significant change in TNF-α (SMD= 0.42 pg/ml; 95% CI: -0.31, 1.16; P= 0.257) and IL-2 levels (SMD= 1.64 pg/ml; 95% CI: -1.31, 4.59; P= 0.277) following Zn supplementation. However, Zn could increase IL-2 significantly after deletion of one arm in sensitivity analysis (SMD= 2.96 pg/ml; 95% CI: 2.03, 3.88; P< 0.05). Conclusively, Zn supplementation can decrease the IL-6 level. Zn increased IL-2 level after sensitivity analysis. Zn supplementation has not ameliorative effects on TNF-α.

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Section: Discussionmentioning

confidence: 97%

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

et al. 2021

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“…19 On the other hand, zinc supplementation could modulate T cell to maintain IL-2 level in seropositive contact of leprosy patients. 20 Zinc deficiency may interrupt the process of signal transduction of T cell. The role affects to the lymphocite protein tyrosine kinase/ LcK, protein kinase C and extracellular regulated kinase/ Erk.…”

Section: Discussionmentioning

confidence: 99%

Correlation of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy

Rahfiludin¹,

Ginandjar²,

Pangestuti³

2012

Med J Indones

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Latar belakang: Berbagai studi menunjukkan pasien kusta memiliki status zinc yang rendah. Namun status zinc pada narakontak kusta, yang ditentukan dengan kadar IgM anti-PGL1, belum diketahui. Tujuan penelitian ini untuk mengetahui hubungan antara kadar zinc plasma dengan IgM anti-PGL-1 pada narakontak kusta. Metode: Penelitian ini merupakan studi observasi. Subjek penelitian terdiri dari 186 narakontak kusta. Pengukuran status plasma zinc menggunakan atomic absorption spectrophotometer sedangkan pemeriksaan kadar IgM anti-PGL1 level menggunakan ELISA (Polyclonal rabbit anti human IgM/HRP/(Dako ®). Hasil: Kadar rata-rata IgM anti-PGL1 subjek adalah 804 unit/mL (± 439,4) dan kadar rata-rata plasma zinc adalah 16,6 µmol/L (± 3,5). Ada hubungan yang signifikan antara kadar plasma zinc dengan IgM anti-PGL1 (r =-0,230; p =0,002).

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“…9,12- 15 Penelitian sebelumnya meneliti pengaruh suplementasi seng terhadap kadar IL-2 pada narakontak kusta yang seropositif menggunakan dosis 40 miligram seng/hari selama 3 bulan didapatkan hasil kadar IL-2 pada kelompok yang menerima seng dibandingkan dengan kelompok plasebo berbeda bermakna pada kedua kelompok (p=0,037). 13 Penelitian public health terdahulu yang dilakukan Rahfiludin terhadap narakontak pasien kusta di Jawa Timur dan Jawa Tengah menyatakan terdapat korelasi antara kadar IgM anti PGL-1 dan kadar Seng. 14 Terdeteksinya kusta subklinis serta pemberian suplementasi pada narakontak dapat digunakan sebagai dasar, diharapkan dapat memutus rantai penularan penyakit kusta.…”

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Suplementasi seng (Zn) menurunkan kadar IgM anti PGL-1 pada narakontak serumah pasien kusta tipe multibasiler

Wijaya

Rusyati

Praharsini

2021

Intisari Sains Medis

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Background: Indonesia ranks third highest of new cases of leprosy after India and Brazil. Transmission of leprosy through inhalation and prolonged close contact. Families who live in the same house have the highest risk for infection. Currently, several studies have found a correlation between IgM anti-PGL-1 levels with micronutrient deficiencies, especially zinc, which is associated with cellular immunity. This study aimed to investigate the effect of 40 mg elemental zinc supplementation per day for four weeks on IgM anti-PGL-1 levels. Methods: An experimental one-group pre-test and post-test design conducted from February to May 2021. The samples were all close contact persons with multibacillary leprosy patients aged 18-65 years who visited the Dermatology and Venereology Outpatient Clinic, Sanglah General Hospital, Denpasar during the study period by consecutive sampling. The history taking, physical examination, and blood sampling were carried out at the to evaluate IgM anti-PGL-1 and zinc levels. Results: Mean serum zinc level before and after supplementation were 79.00±9.67 g/dl and 95.16±31.84 g/dl, mean difference 25.21±32.12 g/dl (p<0.001). IgM anti-PGL-1 mean level before and after supplementation were 843.21±878.51 u/ml and 465.68±735.21 u/ml, mean difference 377.52±309.62 u/ml (p<0.001). Correlation test of different mean levels of zinc with different mean levels of IgM anti-PGL-1 resulted with r=0.630 and p=0.004. Conclusion: Forty mg elemental zinc per day for four weeks may increase serum zinc levels and reduce IgM anti-PGL-1 in close contact with multibacillary leprosy patients (p<0.05). Higher mean increase in serum zinc levels follower by higher mean decrease of IgM anti-PGL-1 levels. Latar Belakang: Indonesia menduduki peringkat ketiga jumlah kasus baru kusta terbanyak setelah India dan Brazil. Keluarga yang tinggal serumah memiliki resiko yang paling tinggi untuk terkena infeksi. Saat ini ditemukan beberapa penelitian yang menghubungkan kadar PGL-1 dengan defisiensi mikronutrien, salah satunya yaitu seng. Penelitian ini bertujuan untuk meneliti efek pemberian suplementasi seng elemental 40 mg per hari selama 4 minggu terhadap kadar IgM anti PGL-1. Metode: Penelitian eksperimental one group pre-test post-test design yang dilakukan pada Februari hingga Mei 2021. Sampel adalah seluruh individu narakontak dengan pasien kusta tipe multibasiler berusia 18-65 tahun yang berkunjung ke Poliklinik Kulit dan Kelamin RSUP Sanglah Denpasar selama periode penelitian berlangsung secara consecutive sampling. Anamnesis, pemeriksaan fisik, dan pengambilan sampel darah dilakukan untuk pemeriksaan IgM anti PGL-1 dan kadar serum seng. Hasil: Rerata kadar serum seng sebelum dan sesudah diberikan suplementasi yaitu 79,00±9,67 µg/dl dan 95,16±31,84 µg/dl dengan beda rerata 25,21±32,12 µg/dl (p<0,001). Rerata kadar IgM anti PGL-1 sebelum dan sesudah diberikan suplementasi yaitu 843,21±878,51 u/ml dan 465,68 ± 735,21 u/ml dengan beda rerata 377,52±309,62 u/ml (p<0,001). Uji korelasi beda rerata kadar seng dengan beda rerata kadar IgM anti PGL-1 yaitu r=0,630 dan p=0,004. Simpulan: Pemberian suplementasi seng elemental 40 mg perhari selama 4 minggu dapat meningkatkan kadar serum seng dan menurunkan kadar serum IgM anti PGL-1 pada narakontak pasien kusta tipe multibasiler (p<0,05). Semakin tinggi selisih rerata peningkatan kadar seng serum, semakin tinggi selisih rerata penurunan kadar IgM anti PGL-1.

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Zinc supplementation could modulate T cell to maintain interleukin-2 level in seropositive contact of leprosy patients

Cited by 7 publications

References 6 publications

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials

Correlation of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy

Suplementasi seng (Zn) menurunkan kadar IgM anti PGL-1 pada narakontak serumah pasien kusta tipe multibasiler

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