Zinc supplement augments the suppressive effects of repurposed drugs of NF-kappa B inhibitor on ACE2 expression in human lung cell lines in vitro

Lee, Ming Cheng; Chen, Yin‐Kai; Hsu, Yih-Jen; Lin, Bor‐Ru

doi:10.1101/2021.01.27.428372

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…NF-kB can modulate ACE2 expression, and one study reported that ACE2 mRNA could be suppressed by NF-kB inhibitors, such as pyrrolidine dithiocarbamate (PDTC). 186,187 Since SARS-CoV-2 can bind to ACE2, NF-kB inhibitors have been suggested to be beneficial in COVID-19. This binding also decreases the level of ACE2, resulting in increased Ang2 levels.…”

Section: Reviewmentioning

confidence: 99%

Cytokines and microRNAs in SARS-CoV-2: What do we know?

Rarani

Rashidi

Abadi

et al. 2022

Molecular Therapy - Nucleic Acids

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Section: Reviewmentioning

confidence: 99%

Cytokines and microRNAs in SARS-CoV-2: What do we know?

Rarani

Rashidi

Abadi

et al. 2022

Molecular Therapy - Nucleic Acids

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“… 143 It could also act synergistically when co-administered with azithromycin and triclabendazole or emetine on the expression of ACE-2. 156 , 157 …”

Section: Functional Food Ingredients Were Effective In Virus Infectionsmentioning

confidence: 99%

A Review on the Antiviral Activity of Functional Foods Against COVID-19 and Viral Respiratory Tract Infections

Omer¹,

Khorshidi²,

Mortazavi³

et al. 2022

IJGM

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Due to the absence of successful therapy, vaccines for protection are continuously being developed. Since vaccines must be thoroughly tested, viral respiratory tract infections (VRTIs), mainly coronaviruses, have seriously affected human health worldwide in recent years. In this review, we presented the relevant data which originated from trusted publishers regarding the practical benefits of functional foods (FFs) and their dietary sources, in addition to natural plant products, in viral respiratory and COVID-19 prevention and immune-boosting activities. As a result, FFs were confirmed to be functionally active ingredients for preventing COVID-19 and VRTIs. Furthermore, the antiviral activity and immunological effects of FFs against VRTIs and COVID-19 and their potential main mechanisms of action are also being reviewed. Therefore, to prevent COVID-19 and VRTIs, it is critical to identify controlling the activities and immune-enhancing functional food constituents as early as possible. We further aimed to summarize functional food constituents as a dietary supplement that aids in immune system boosting and may effectively reduce VRTIs and COVID-19 and promote therapeutic efficacy.

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A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients

Gouda

Adbelruhman

Elbendary

et al. 2021

Saudi Journal of Biological Sciences

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Hypozincemia is prevalent in severe acute respiratory syndrome coronavirus-2 (SARS-COV-2)-infected patients and has been considered as a risk factor in severe coronavirus disease-2019 (COVID-19). Whereas zinc might affect SARS-COV-2 replication and cell entry, the link between zinc deficiency and COVID-19 severity could also be attributed to the effects of COVID-19 on the body metabolism and immune response. Zinc deficiency is more prevalent in the elderly and patients with underlying chronic diseases, with established deleterious consequences such as the increased risk of respiratory infection. We reviewed the expected effects of zinc deficiency on COVID-19-related pathophysiological mechanisms focusing on both the renin–angiotensin and kinin-kallikrein systems. Mechanisms and effects were extrapolated from the available scientific literature. Zinc deficiency alters angiotensin-converting enzyme-2 (ACE2) function, leading to the accumulation of angiotensin II, des-Arg9-bradykinin and Lys-des-Arg9-bradykinin, which results in an exaggerated pro-inflammatory response, vasoconstriction and pro-thrombotic effects. Additionally, zinc deficiency blocks the activation of the plasma contact system, a protease cascade initiated by factor VII activation. Suggested mechanisms include the inhibition of Factor XII activation and limitation of high-molecular-weight kininogen, prekallikrein and Factor XII to bind to endothelial cells. The subsequent accumulation of Factor XII and deficiency in bradykinin are responsible for increased production of inflammatory mediators and marked hypercoagulability, as typically observed in COVID-19 patients. To conclude, zinc deficiency may affect both the renin–angiotensin and kinin-kallikrein systems, leading to the exaggerated inflammatory manifestations characteristic of severe COVID-19.

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Zinc supplement augments the suppressive effects of repurposed drugs of NF-kappa B inhibitor on ACE2 expression in human lung cell lines in vitro

Cited by 3 publications

References 31 publications

Cytokines and microRNAs in SARS-CoV-2: What do we know?

Cytokines and microRNAs in SARS-CoV-2: What do we know?

A Review on the Antiviral Activity of Functional Foods Against COVID-19 and Viral Respiratory Tract Infections

A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients

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