Zinc-releasing calcium phosphate for stimulating bone formation

Ito, Atsuo; Kawamura, Haruo; Otsuka, Makoto; Ikeuchi, Masako; Ohgushi, Hajime; Ishikawa, Kunio; Onuma, Kazuo; Kanzaki, Noriko; Sogo, Yu; Ichinose, Noboru

doi:10.1016/s0928-4931(02)00108-x

Cited by 257 publications

(175 citation statements)

References 17 publications

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“…It is believed that bioglasses doped with ions such as Ga 3? and Zn 2? offer antibacterial, anti-inflammatory, anti-tumor and immunosuppressive properties [52][53][54]. In addition, Ga increases the Lewis acidic strength of bioglass, which makes them suitable for interaction with biomolecules such as proteins and drugs [37].…”

Section: Indirect Immunostainingmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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Section: Indirect Immunostainingmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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“…In addition to Zn, these cements have been synthesized to contain strontium (Sr) [8,9]. Both Sr and Zn inhibit osteoclastic turnover and promote osteoblastic turnover, resulting in increased bone strength and decreased fracture risk [10][11][12][13][14].…”

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confidence: 99%

TEM analysis of apatite surface layers observed on zinc based glass polyalkenoate cements

et al. 2007

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“…Zinc is an essential trace element [2,[4][5][6][7] whose addition promotes bone formation as it stimulates osteoblast proliferation and differentiation [8]. In addition to that it has profound antibacterial properties [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…ZnO increases the tendency towards crystalline phase separation as it decreases the viscosity of glass. Zinc oxide is known * E-mail: madeehariaz2762@yahoo.com to be a potent inhibitor of crystal growth of apatite phase; it reduces the dissolution rate, thus improving chemical stability of glass [4]. An increase in concentration of ZnO in glass and glass-ceramic system causes decline in apatite forming ability.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of bioactivity of SiO2-CaO-P2O5-Na2O-CaF2-ZnO glass-ceramics

Riaz

Zia

Saleemi

et al. 2014

Materials Science-Poland

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Zinc is an essential trace element that stimulates bone formation but it is also known as an inhibitor of apatite crystal growth. In this work addition of ZnO to SiO 2 -CaO-P 2 O 5 -Na 2 O-CaF 2 glass-ceramic system was made by conventional meltquenching technique. DSC curves showed that the addition of ZnO moved the endothermic and exothermic peaks to lower temperatures. X-ray diffraction analysis did not reveal any additional phase caused by ZnO addition and showed the presence of wollastonite and hydroxyapatite crystalline phases only in all the glass-ceramic samples. As bio-implant apatite forming ability is an essential condition, the surface reactivity of the prepared glass-ceramic specimens was studied in vitro in Kokubo's simulated body fluid (SBF) [1] with ion concentration nearly equal to human blood plasma for 30 days at 37°C under static condition. Atomic absorption spectroscopy (AAS) was used to study the changes in element concentrations in soaking solutions and XRD, FT-IR and SEM were used to elucidate surface properties of prepared glass-ceramics, which confirmed the formation of HCAp on the surface of all glass-ceramics. It was found that the addition of ZnO had a positive effect on bioactivity of glassceramics and made it a potential candidate for restoration of damaged bones.

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Zinc-releasing calcium phosphate for stimulating bone formation

Cited by 257 publications

References 17 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

TEM analysis of apatite surface layers observed on zinc based glass polyalkenoate cements

In vitro evaluation of bioactivity of SiO2-CaO-P2O5-Na2O-CaF2-ZnO glass-ceramics

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