Zinc oxide loaded chitosan-elastin-sodium alginate nanocomposite gel using freeze gelation for enhanced adipose stem cell proliferation and antibacterial properties

Application of stem cells in regeneration medicine

“…258 A study reported that to enhance the attachment ability and preserve bone marrow MSCs in hydrogels, the viability, density, and delivery of paracrine factors in hMSCs using agarose-carbohydrate hydrogels must be optimized. 259,260 Hydrogels efficiently deliver exosomes to individual cells, maintaining the biological activity of exosomes while performing various repairs. Hydrogels can stimulate the release of MSC-Exos and heal better than exosomes or hydrogels alone, 261 suggesting that sustained release of exosomes and hydrogels can synergistically promote wound healing.…”

“…The use of acrylic hyaluronic acid (HA) hydrogel microspheres, a biodegradable hydrogel, can deliver carriers in vivo and release cells to local targets 258 . A study reported that to enhance the attachment ability and preserve bone marrow MSCs in hydrogels, the viability, density, and delivery of paracrine factors in hMSCs using agarose‐carbohydrate hydrogels must be optimized 259,260 …”

ZnO based 0–3D diverse nano-architectures, films and coatings for biomedical applications

“…The scaffold was able to promote the adhesion and proliferation of osteoblast cells, and it showed good biocompatibility. 34 Another recent study developed a ZnO nanoparticle (NP)-based scaffold for cartilage tissue engineering. The scaffold was fabricated by mixing ZnO NPs with a hydrogel.…”

In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co3O4 nanoparticles loaded biomimetic scaffold for preclinical analysis

“…Thus, nanocomposite membranes offer sufficient conditions for the preferred components to penetrate by providing a barrier to other detrimental components. 13 Therefore, metal oxide nanoparticles have unique characteristics, particularly cobalt oxide nanoparticles (Co 3 O 4 NPs), widely used in various chemical and biological applications including energy storage, electrochromic sensors, heterogeneous catalysis and dyes degradation. [14][15][16] Cobalt oxide is p-type semiconductor and has excellent electrochemical properties due to its Co 2+ , Co 3+ , and Co 4+ oxidation states, with different coordination geometries such as tetrahedral, pyramidal, and octahedral.…”

“…Thus, the literature revealed that optimizing the polymeric base matrix with metal oxide nanofillers can significantly improve scaffold nanocomposite's physicochemical and biological properties due to their effect on surface area and molecular interactions with polymer chains. Thus, nanocomposite membranes offer sufficient conditions for the preferred components to penetrate by providing a barrier to other detrimental components 13 …”