Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection

Zhang, Qian; Zhang, Diming; Li, Nantao; Lu, Yanli; Yao, Yao; Li, Shuang; Liu, Qingjun

doi:10.2116/analsci.32.387

Cited by 15 publications

(9 citation statements)

References 37 publications

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“…The olfactory responses to the engineered zinc nanoparticles are dose-dependent and zinc-specific because other tested metal nanoparticles, including copper, silver, gold, and platinum, do not enhance the response. The enhancement of the odorant response by the engineered zinc nanoparticles was reproduced in Zhejiang University 16 . Rat olfactory epithelium was mounted on a microelectrode array and an electrical signal elicited by an odorant was substantially enhanced when the engineered zinc nanoparticles were added to an odorant.…”

Section: Discussionmentioning

confidence: 99%

Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant

Singletary

Lau

Hagerty

et al. 2020

Sci Rep

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The role of zinc in neurobiology is rapidly expanding. Zinc is especially essential in olfactory neurobiology. Naturally occurring zinc nanoparticles were detected in olfactory and nasal respiratory epithelia and cilia in animals. The addition of these nanoparticles to a mixture of odorants, including ethyl butyrate, eugenol, and carvone, considerably increased the electrical responses of the olfactory sensory receptors. Studies of these nanoparticles by ransmission electron microscopy (TEM) and selected area electron diffraction revealed metal elemental crystalline zinc nanoparticles 2–4 nm in diameter. These particles did not contain oxidized zinc. The enhancement of the odorant responses induced by the endogenous zinc nanoparticles appears to be similar to the amplification produced by engineered zinc nanoparticles. Zinc nanoparticles produce no odor response but increase odor response if mixed with an odorant. These effects are dose-dependent and reversible. Some other metal nanoparticles, such as copper, silver, gold, and platinum, do not have the effects observed in the case of zinc nanoparticles. The olfactory enhancement was observed in young and mature mouse olfactory epithelium cultures, in the dissected olfactory epithelium of rodents, and in live conscious dogs. The physiological significance of the detected endogenous metal nanoparticles in an animal tissue has been demonstrated for the first time. Overall, our results may advance the understanding of the initial events in olfaction.

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Section: Discussionmentioning

confidence: 99%

Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant

Singletary

Lau

Hagerty

et al. 2020

Sci Rep

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“…In the early stage, the drop coating is a simple and easy immobilization method, which is especially suitable for the immobilization of olfactory and gustatory-related protein molecules, cells and tissues [ 68 , 69 ]. However, this kind of physical immobilization strategy has many shortcomings, including difficulty ensuring the uniform and firm distribution of biomolecules on the transducer surface and difficulty guaranteeing the effect of the device substrate with low biocompatibility on the coupling degree of cell tissues on its surface.…”

Section: Immobilization Strategies Of Sensitive Materialsmentioning

confidence: 99%

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

Chen

Tian

et al. 2022

Biosensors

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The biomimetic olfactory and gustatory biosensing devices have broad applications in many fields, such as industry, security, and biomedicine. The development of these biosensors was inspired by the organization of biological olfactory and gustatory systems. In this review, we summarized the most recent advances in the development of detection strategies for chemical sensing based on olfactory and gustatory biomimetic biosensors. First, sensing mechanisms and principles of olfaction and gustation are briefly introduced. Then, different biomimetic sensing detection strategies are outlined based on different sensing devices functionalized with various molecular and cellular components originating from natural olfactory and gustatory systems. Thereafter, various biomimetic olfactory and gustatory biosensors are introduced in detail by classifying and summarizing the detection strategies based on different sensing devices. Finally, the future directions and challenges of biomimetic biosensing development are proposed and discussed.

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“…Nanoscale electroanalytical devices are also used to improve healthcare diagnostics, including the electronic nose which is capable of detecting odorants and chemicals associated with disease (Son et al, 2017; Q. Zhang et al, 2016). Similarly, in an attempt to design a self‐sustaining device a photosynthetic e‐skin has been developed capable of responding to touch and ultraviolet radiation (Ravi et al, 2018).…”

Section: Nanoscale Electroanalytical Devicesmentioning

confidence: 99%

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Gibney

Hicks

Robinson

et al. 2021

WIREs Nanomed Nanobiotechnol

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Bioelectronic medicine aims to interface electronic technology with biological components and design more effective therapeutic and diagnostic tools. Advances in nanotechnology have moved the field forward improving the seamless interaction between biological and electronic components. In the lab many of these nanobioelectronic devices have the potential to improve current treatment approaches, including those for cancer, cardiovascular disorders, and disease underpinned by malfunctions in neuronal electrical communication. While promising, many of these devices and technologies require further development before they can be successfully applied in a clinical setting. Here, we highlight recent work which is close to achieving this goal, including discussion of nanoparticles, carbon nanotubes, and nanowires for medical applications. We also look forward toward the next decade to determine how current developments in nanotechnology could shape the growing field of bioelectronic medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Biosensing

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Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection

Cited by 15 publications

References 37 publications

Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant

Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

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