Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure

McCarty, Mark F.

doi:10.1016/j.mehy.2012.07.043

Cited by 44 publications

(31 citation statements)

References 96 publications

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“…In the Korean NHANES experience, there is a strong correlation between blood Cd and development of metabolic syndrome [76], the mechanisms of which remain unelucidated but may involve mechanical distortion of the insulin receptor. The Cd effect on insulin resistance may be minimized by supplementation of Fe, Ca, Mg, and Zn (which also decreases the Cd-associated risks of cancers, fractures, vascular disorders, and total mortality) [77]. …”

Section: Clinical Toxicitymentioning

confidence: 99%

Cadmium Toxicity and Treatment

Bernhoft¹

2013

The Scientific World Journal

481

270

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Cadmium is a heavy metal of considerable toxicity with destructive impact on most organ systems. It is widely distributed in humans, the chief sources of contamination being cigarette smoke, welding, and contaminated food and beverages. Toxic impacts are discussed and appear to be proportional to body burden of cadmium. Detoxification of cadmium with EDTA and other chelators is possible and has been shown to be therapeutically beneficial in humans and animals when done using established protocols.

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Section: Clinical Toxicitymentioning

confidence: 99%

Cadmium Toxicity and Treatment

Bernhoft¹

2013

The Scientific World Journal

481

270

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“…The standard management of heavy metal intoxication; chelators may have a minor role in Cd toxicity as these therapies have little ability to penetrate cells where most of Cd was stored [1,7]. With increasing evidence of oxidative stress as a possible mechanism of Cd toxicity [8], variable antioxidants have been tried as possible protective agents in Cd toxicity for example zinc [9] selenium [10], vitamin C and E [11].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

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Adult male Sprague rats weighting (220 ± 30gm) were purchased from Faculty of Agriculture, Minia University Egypt. Experimen- AbstractCadmium (Cd) is a common environmental hazardous heavy metal. The standard treatment of heavy metal intoxication; chelators may have a minor role in Cd toxicity. Montelukast (ML) is an anti-inflammatory drug that is used mainly for managing asthmatic patients. Recent workers have tested ML for its antioxidant properties in various conditions and obtained encouraging results as regarding this effect. We investigated the protective and antioxidant effect of ML on pituitary gland, a highly sensitive organ to Cd toxicity. Four groups of rats were used and received distilled water, 10mg/kg ML, 3mg/kg Cd, and 10mg ML plus 3mg/kg Cd respectively. Antioxidant, histological, immunohistochemical and hormonal effects of Cd and ML were evaluated. The detrimental effect of Cd on pituitary gland was abolished by ML. The diminished hormonal effect of Cd was restored to normal levels. The increased MDA level and depleted oxidative enzymes on pituitary gland of rat exposed to Cd were restored by ML. lastly, histological and apoptotic effects of Cd were also, corrected significantly by ML. It is concluded that ML can protect against Cd-induced pituitary gland toxicity.

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“…The antagonism between Cd and Zn is well documented and is probably one of the most investigated toxic metalbioelement interactions (32,33). Thus, Rogalska et al (29) concluded that Zn supplementation during chronic cadmium exposure may have a protective role against the proatherogenic action of Cd by preventing hyperlipidemia and lipid peroxidation in rats.…”

mentioning

confidence: 99%

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg -1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg -1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO 3 ) and perchloric acid (HClO 4 ) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

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Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure

Cited by 44 publications

References 96 publications

Cadmium Toxicity and Treatment

Cadmium Toxicity and Treatment

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

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