Cadmium Toxicity and Treatment

Bernhoft, Robin A.

doi:10.1155/2013/394652

Cited by 482 publications

(304 citation statements)

References 109 publications

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“…In addition, cadmium competes with zinc and magnesium, which are needed for heme synthesis or mitochondrial function [12,19] . Cadmium also impairs immune function, arrests the cell cycle, and induces apoptosis in splenocytes; furthermore, it increases the rates of autoimmunity and production of non-specific antibodies.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Cadmium on Human Middle Ear Epithelial Cells

Song

Yoon²,

Kim

et al. 2016

Int Adv Otol

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OBJECTIVE: Cadmium (Cd 2+) exposure can occur through passive smoking, ambient air pollution, and food. Even low exposure can affect hearing and cause lung disease. Here we investigated whether cadmium causes cytotoxicity, induces inflammation, or increases mucin gene expression in immortalized human middle ear epithelial cells (HMEECs). MATERIALS and METHODS:Cell viability was investigated using the MTT assay following Cd 2+ treatment. Increases in apoptosis and necrosis were determined, and the production of reactive oxygen species (ROS) was measured. We analyzed the expression of an inflammatory cytokine (COX-2) gene and a mucin gene (MUC5AC) using RT-PCR. RESULTS: Exposure to >20 µM Cd2+ caused a significant decrease in cell viability. Hoechst 33258 staining showed apoptotic morphology of heterogeneous intensity, condensation, and fragmentation after Cd2+ exposure. Cd 2+ was shown to increase cell death by apoptosis and necrosis by annexin V-FITC/PI double staining. Cd 2+ exposure increased ROS production and COX-2 and MUC5AC expressions. CONCLUSION:Our findings suggest that environmental cadmium exposure is related to the development of otitis media.

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Section: Discussionmentioning

confidence: 99%

“…Cadmium also impairs immune function, arrests the cell cycle, and induces apoptosis in splenocytes; furthermore, it increases the rates of autoimmunity and production of non-specific antibodies. It also decreases lymphocyte proliferation and natural killer cell activity [19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Cadmium on Human Middle Ear Epithelial Cells

Song

Yoon²,

Kim

et al. 2016

Int Adv Otol

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“…al, 2008;Flora et. al, 2012;Bernhoft, 2012;Bernhoft, 2013). In children, heavy metals are linked to high death risk, delayed nerve development, intellectual and behavioural problems, as well as peripheral nerve damage and hearing loss (Satoh, 2000;Crossgrove, 2004;Flora et.…”

Section: Health Impact Of Bauxite and Heavy Metals Contaminationmentioning

confidence: 99%

“…Mercury passes through bloodbrain barrier, affects the brain and causes neurological problems; such as weakness, tiredness, tremors and loss of motor control, with ataxia and sensory loss affecting sight, hearing and speech (Satoh, 2000;Bernhoft, 2012). Long term cadmium exposure causes renal and bone toxicity and manifest as Itai-Itai disease with fractures, osteoporosis, osteomalacia and renal tubular malfunction (Bernhoft, 2013). Cadmium has been linked to lung cancer and emphysema (Nawrot et.…”

Section: Health Impact Of Bauxite and Heavy Metals Contaminationmentioning

confidence: 99%

A Review of the Occupational and Environmental Health Hazards of Bauxite Mining in Malaysia

Qureshi

Nordin

Yiqian

et al. 2017

International Conference on Public Health

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This review aims to explore the potential occupational and environmental health hazards on lives of miners and neighbouring communities, in relation to bauxite mining in Malaysia. The mining related environmental issues include air, water and soil pollution due to bauxite dust; its leaching into water sources reduces soil fertility, affects agricultural food produce and aquatic life. Bauxite occupational exposure affects the health of miners, apart from negative health impacts on neighbouring communities; such as frequent respiratory symptoms, and contamination of drinking water. Other potential health effects of bauxite mining include noise-induced hearing loss and mental stress. This review describes the processes of bauxite mining, its components, the residual trace elements, and their impacts on environment and health of exposed workers and communities. It also discusses Malaysian legal requirements and occupational exposure standards for bauxite.

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“…Cd is an element very often associated with Zn and Cu but is extremely harmful to living organisms [BERNHOFT, 2013] . Commercially we can purchase various Cd-containing objects such as: TV screens, batteries, lasers, cosmetics, various paint categories [ROLLA et al, 2012] .…”

Section: Introductionmentioning

confidence: 99%

Physical–chemical parameters and the level of heavy metals in cow milk in the Baia Mare area

Coroian¹,

Mireșan²,

Cocan³

et al. 2017

bjbabe

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Abstract. Heavy metals are important pollutants in the environment and can cause problems for the organisms, and the bioaccumulation of heavy metals in the food chain can have adverse effects on human health. Regulations on the legally accepted amounts of heavy metals in food and in the body are very precise. The purpose of this paper was to evaluate the level of heavy metals in cow milk from different localities in the Baia Mare area, considered a very polluted area. The physical-chemical parameters and heavy metals in milk were determined. The determination of heavy metals in milk was performed by inductively coupled plasma mass spectrometry or ICP-MS used to identify and quantify the Pb, Cd, Cu, and Zn elements. The highest concentrations of Pb were observed in samples collected in Firiza locality with an average value of (43.22±0.62) (μg/L) and the lowest concentrations are for the samples analyzed in Săcălăşeni (11.53±0.33) (mg/L) (μg/L). Cd in milk did not show very large variations between localities, so the lowest concentrations were recorded in Săcălăşeni (4.32±0.13) and the highest ones were observed in the locality Firiza (10.93±0.39) (μg/L). The highest concentrations were observed for the Zn in milk, with an interval between (2255.20±7.14) (μg/L) in Săcălăşeni and (3855.80±5.11) (μg/L) for the analyzed samples from Firiza.

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Cadmium Toxicity and Treatment

Cited by 482 publications

References 109 publications

Effect of Cadmium on Human Middle Ear Epithelial Cells

Effect of Cadmium on Human Middle Ear Epithelial Cells

A Review of the Occupational and Environmental Health Hazards of Bauxite Mining in Malaysia

Physical–chemical parameters and the level of heavy metals in cow milk in the Baia Mare area

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