Zero-order drug release cellulose acetate nanofibers prepared using coaxial electrospinning

Yu, Deng‐Guang; Li, Xiaoyan; Wang, Xia; Chian, Wei; Liao, Yaozu; Li, Ying

doi:10.1007/s10570-012-9824-z

Cited by 109 publications

(71 citation statements)

References 27 publications

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“…Here, the concept of electrospun living bacteria solid dosage forms containing living bacteria was put forward using a single fluid electrospinning of Nagy et al -eXPRESS Polymer Letters Vol.8, No.5 (2014) suspensions. Coaxial electrospinning [47][48][49] could further expand this concept owing to its capability to manipulate nanostructure.…”

Section: Encapsulation Of Lactobacillus Acidophilus Into Polymer Nanomentioning

confidence: 99%

Nanofibrous solid dosage form of living bacteria prepared by electrospinning

Nagy¹,

Wagner²,

Suhajda³

et al. 2014

Express Polym. Lett.

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Section: Encapsulation Of Lactobacillus Acidophilus Into Polymer Nanomentioning

confidence: 99%

Nanofibrous solid dosage form of living bacteria prepared by electrospinning

Nagy¹,

Wagner²,

Suhajda³

et al. 2014

Express Polym. Lett.

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“…This can be explained by the phase transformation which KET undergoes during the process of electrospinning. In its crystalline form, KET molecules are bound together in dimers through intermolecular hydrogen bonds, resulting in the appearance of the distinct peak at 1694 cm -1 [35,36].…”

Section: Ftir Spectroscopymentioning

confidence: 99%

A thermosensitive drug delivery system prepared by blend electrospinning

Liu

Sang

et al. 2017

Colloids and Surfaces B: Biointerfaces

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A thermosensitive drug delivery system prepared by blend electrospinning, Colloids and Surfaces B: Biointerfaceshttp://dx.doi.org/10. 1016/j.colsurfb.2017.07.058 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  5. PDEGMA/EC fibers were found to have good biocompatibility towards fibroblasts. Abstract:2 In this study, the thermosensitive polymer poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) was synthesized and electrospun into fibers by blending with ethyl cellulose (EC). Fibers were additionally prepared loaded with ketoprofen (KET) as a model drug. Smooth cylindrical fibers could generally be observed by electron microscopy, although there were some beads and fused fibers visible in the KET-loaded materials. KET was found to be amorphously distributed in the fibers on the basis of X-ray diffraction data. From water contact angle measurements, it was clear that the wettability of the EC/PDEGMA fibers changed as the temperature increased, with the fibers becoming markedly more hydrophobic. In vitro drug release studies showed that KET was released over a prolonged period of time with the fibers having different release profiles at 25 and 37 ºC, reflecting their thermosensitive properties.Furthermore, the materials were found to have good biocompatibility towards L929fibroblasts. Thus, the fibers prepared in this work have potential as smart stimuliresponsive drug delivery systems.

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“…If the fibers are appropriately designed, core-shell drug-loaded fibers can additionally eliminate the initial burst release commonly seen with monolithic fibers, resulting in zero-order release materials or multiple-phase controlled release. 21,22 The simultaneous release of multiple drugs is also possible, 23,24 and a wider range of polymers can be processed with the coaxial approach than with single-fluid spinning. 25 Given that multiple drugs can be incorporated into coaxial electrospun fibers and released into particular parts of the body, here we aimed to fabricate a series of novel theranostic systems using this process.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

Jin

Geraldes

et al. 2016

Mol. Pharmaceutics

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Abstract:New methods for creating theranostic systems with simultaneous encapsulation of therapeutic, diagnostic and targeting agents are much sought after. This work reports for the first time the use of coaxial electrospinning to prepare such systems in the form of core-shell fibers. Eudragit S100 was used to form the shell of the fibers, while the core comprised polyethylene oxide loaded with the magnetic resonance contrast agent Gd(DTPA) (Gd(III) diethylenetriaminepentaacetate hydrate) and indomethacin as a model therapeutic agent. The fibers had linear cylindrical morphologies with clear core-shell structures, as demonstrated by electron microscopy. X-ray diffraction and differential scanning calorimetry proved that both indomethacin and Gd(DTPA) were present in the fibers in the amorphous physical form. This is thought to be a result of intermolecular interactions between the different components, the presence of which was suggested by IR spectroscopy. In vitro dissolution tests indicated that the fibers could provide targeted release of the active ingredients through a combined mechanism of erosion and diffusion. The proton relaxivities for Gd(DTPA) released from the fibers into tris buffer increased (r 1 =5.03-10.13 s -1 mM -1 ; r 2 =8.28-14.96 s -1 mM -1 ) compared with fresh Gd(DTPA) (r 1 =4.37 s -1 mM -1 and r 2 =4.85 s -1 mM -1 ), proving that electrospinning has not diminished the contrast properties of the complex. The new systems reported herein thus offer a new platform for delivering therapeutic and imaging agents simultaneously to the colon.

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Zero-order drug release cellulose acetate nanofibers prepared using coaxial electrospinning

Cited by 109 publications

References 27 publications

Nanofibrous solid dosage form of living bacteria prepared by electrospinning

Nanofibrous solid dosage form of living bacteria prepared by electrospinning

A thermosensitive drug delivery system prepared by blend electrospinning

Theranostic Fibers for Simultaneous Imaging and Drug Delivery

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