Zeolites in biomedical application: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in topical therapy

Cerri, Guido; Gennaro, Maurizio de; Bonferoni, Maria Cristina; Caramella, Carla

doi:10.1016/j.clay.2004.04.004

Cited by 72 publications

(40 citation statements)

References 37 publications

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“…The reaction of dehydroxylation accompanies the collapse of the zeolite framework. In fact after a heating time of 2 h at 600 °C, ES-NH becomes amorphous (Figure 1a), whereas the breakdown of the NH4-clinoptilolite prepared by Tomazevic et al [23] begins at 600 °C, a difference that can be explained by the higher Si/Al ratio of the Serbian clinoptilolite (5.02) [32] with respect to that of the Sardinian zeolite contained in ES-NH (4.71) [28].…”

Section: Discussionmentioning

confidence: 93%

Thermal Transformation of NH4-Clinoptilolite to Mullite and Silica Polymorphs

2017

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Clinoptilolite is a natural zeolite used for the abatement of ammonium in the treatment of urban wastewater. By considering that mullite was obtained through thermal treatment of NH 4 -exchanged synthetic zeolites, this work aimed to evaluate if this phase can be obtained from NH 4 -clinoptilolite. A material containing about 90 wt % of clinoptilolite, prepared using a Sardinian zeolite-rich rock, was NH 4 -exchanged and subjected to treatments up to 1200 • C. After dehydration, de-ammoniation, and dehydroxylation processes, the clinoptilolite structure collapsed at 600 • C. An association of mullite, silica polymorphs, and glass, whitish in color, was obtained for treatments between 1000 and 1200 • C. The higher degree of crystallinity was reached after a 32 h heating at 1100 • C: mullite 22 wt %, cristobalite 59 wt %, tridymite 10 wt %, glass 9 wt %. It is possible to speed up the kinetics of the transformation by increasing the temperature to 1200 • C, obtaining the same amount of mullite in 2 h, but increasing the residual amorphous fraction (16 wt %). These results indicate that NH 4 -clinoptilolite could represent a raw material of potential interest in the ceramic field, in particular in the production of acid refractory, opening scenarios for a possible reuse of clinoptilolite-based exchangers employed in ammonium decontamination.

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Section: Discussionmentioning

confidence: 93%

Thermal Transformation of NH4-Clinoptilolite to Mullite and Silica Polymorphs

2017

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“…3). Lower values of the specific surface area have proved to be effective for a faster desorption [11]. Therefore our particles are suitable for being used as drug delivery vehicles.…”

Section: Characterizationmentioning

confidence: 92%

Carbon coated magnetic nanoparticles for local drug delivery using magnetic implants

Fernández-Pacheco¹,

Ibarra²,

Valdivia³

et al. 2005

Nanobiotechnol

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Bioferrofluids obtained from carbon coated iron nanoparticles are promising candidates for magnetic drug delivery. The carbon cages render the particles biocompatible, and provide a good support for drug adsorption. We propose a method in which gold plated permanent magnets are implanted directly in the affected organ, close to the tumour, by endoscopic techniques. The bioferrofluid charged with the chemotherapeutic agent is injected and the particles attracted to the magnet, then desorption of the drug takes place at the tumoral region. This method seems to be more promising, costless and effective than that based on the application of external magnetic fields. Preliminary results of drug adsorption and a preclinical experimental animal model are described.

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“…The cation exchange capacity of zeolites can be altered by the SiO 2 :Al 2 O 3 ratio of the framework. Zeolites are used in petrochemical industries (Ghobarkar et al, 1999); detergent production (Adams et al, 1995); aquaculture, agriculture, and horticulture (Rehakova et al, 2004); medical applications (Cerri et al, 2004); and water treatment (Wang and Peng, 2010). Recent studies have reported several types of zeolites with various ion exchange capacity and antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Development of durable antimicrobial surfaces containing silver- and zinc-ion–exchanged zeolites

İyigündoğdu¹,

Demirci²,

Baç³

et al. 2014

Turk J Biol

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The present work involves development of stable antimicrobial materials containing silver-and zinc-ion-exchanged zeolites. Faujasite X and Linde type A zeolites were synthesized, and following ion exchange with Ag + and Zn ++ ions they were found to exhibit antimicrobial effects against bacteria (E. coli, P. aeruginosa, and S. aureus), yeast (C. albicans and C. glabrata), and fungi (A. niger and P. expansum). Zeolites-X and -A containing silver and zinc ions were then mixed with various coating materials, including paints and polypropylene, to develop antimicrobial composites. The long-term antimicrobial characteristics of zeolite-containing composite materials were investigated by inoculating selected microorganisms onto the surface of the materials. The results indicated that the higher the zeolite concentration present in the composite, the more long-term antimicrobial activity was achieved. Silver-ion-exchanged zeolites were more effective against bacterial and candidal species, while zinc zeolites exhibited noticeable antifungal properties. Materials manufactured with metal-ion-exchanged zeolites would prevent microbial growth on surfaces, reducing cross-contamination and infection risk as well as the microbial degradation of products.

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Zeolites in biomedical application: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in topical therapy

Cited by 72 publications

References 37 publications

Thermal Transformation of NH4-Clinoptilolite to Mullite and Silica Polymorphs

Thermal Transformation of NH4-Clinoptilolite to Mullite and Silica Polymorphs

Carbon coated magnetic nanoparticles for local drug delivery using magnetic implants

Development of durable antimicrobial surfaces containing silver- and zinc-ion–exchanged zeolites

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