Zein-induced immune response and modulation by size, pore structure and drug-loading: Application for sciatic nerve regeneration

Yu, Jingwen; Ying, Lin; Wang, Guowu; Song, Jie-Liang; Hayat, Uzma; Liu, Chang; Raza, Ali; Huang, Xiaoyun; Lin, Haodong; Wang, Jin‐Ye

doi:10.1016/j.actbio.2021.11.035

Cited by 21 publications

(15 citation statements)

References 57 publications

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“…MXene shows good electrical conductivity, could promote tissue regeneration, and has potential application in neural tissue engineering. There is extensive literature supporting that the optimal porosity of the NGC is a critical feature for achieving neovascularization, modulating the immune response, and nerve growth patency ( Shen et al, 2021 ; Yu et al, 2021 ). In this study, we fabricated PCL NGCs by electrospinning ( Figure 1 ), which had a porous structure and appropriate mechanical properties, and size ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Nan

Lin

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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An electrical signal is the key basis of normal physiological function of the nerve, and the stimulation of the electric signal also plays a very special role in the repair process of nerve injury. Electric stimulation is shown to be effective in promoting axonal regeneration and myelination, thereby promoting nerve injury repair. At present, it is considered that electric conduction recovery is a key aspect of regeneration and repair of long nerve defects. Conductive neural scaffolds have attracted more and more attention due to their similar electrical properties and good biocompatibility with normal nerves. Herein, PCL and MXene-PCL nerve guidance conduits (NGCs) were prepared; their effect on nerve regeneration was evaluated in vitro and in vivo. The results show that the NGCs have good biocompatibility in vitro. Furthermore, a sciatic nerve defect model (15 mm) of SD rats was made, and then the fabricated NGCs were implanted. MXene-PCL NGCs show similar results with the autograft in the sciatic function index, electrophysiological examination, angiogenesis, and morphological nerve regeneration. It is possible that the conductive MXene-PCL NGC could transmit physiological neural electric signals, induce angiogenesis, and stimulate nerve regeneration. This paper presents a novel design of MXene-PCL NGC that could transmit self-originated electric stimulation. In the future, it can be combined with other features to promote nerve regeneration.

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Section: Resultsmentioning

confidence: 99%

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Nan

Lin

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Male Sprague Dawley (SD) rats (200–250 g) were bought from Charles River Laboratory Animal Co., LTD (Zhejiang, China). The implantation experiment of nerve conduits was performed according to our previous method [ 35 ]. Briefly, the sciatic nerve of the right hip was separated and exposed, and a nerve segment of 15 mm was cut.…”

Section: Methodsmentioning

confidence: 99%

Water-responsive 4D printing based on self-assembly of hydrophobic protein “Zein” for the control of degradation rate and drug release

Zhang

Raza

Xue

et al. 2023

Bioactive Materials

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“…The study illustrated in Figure exhibited that zein NGCs with high porosity accelerated nerve regeneration by stimulating other M2 macrophages, leading to a reduced degradation time and enhanced nerve repair efficiency. [ 63 ]…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…[59] Zein inhabits superior thermal and pH stability in comparison with other proteins, [60] and even when wet, zein retains a high degree of mechanical strength regarding compressive structural strength, kink resistance, and bending rigidity. [61][62][63] Scaffolds based on zein have been shown to have exceptional mechanical strength. [64,65] Furthermore, zein protein and peptides have shown antioxidant efficacy and confrontation with microbiological contaminants.…”

Section: Properties Characteristics Referencesmentioning

confidence: 99%

Fabrication of Zein‐Based Fibrous Scaffolds for Biomedical Applications—A Review

Rahman

Dip

Haase

et al. 2023

Macro Materials & Eng

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Zein, which accounts for around 80% of the total protein composition in corn, is a biocompatible and biodegradable substance derived from renewable sources. Although insoluble in water, its amphiphilic characteristics are utilized to generate nanoparticles, nanofibers, microparticles, and even films. Numerous recent studies have demonstrated the potential of zein as a prospective biomaterial to develop fibrous scaffolds for biomedical functions owing to its biocompatibility, fibrous formation, and encapsulating qualities. Fabrication of zein‐based fibrous scaffolds for biomedical applications is achieved by a wide variety of techniques, including electrospinning, wet spinning, freeze drying, and additive manufacturing. This article overviews current advancements in manufacturing techniques for zein‐based fibrous scaffolds. In addition, it summarizes the most recent biomedical applications and research activities utilizing zein‐based fibrous scaffolds. Overall, zein is proposed as a potential biomaterial for the production of fibrous scaffolds that stimulate cell adhesion and proliferation in a number of exciting biomedical applications due to its biodegradability, biocompatibility, and other unique features related to its structure.

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Zein-induced immune response and modulation by size, pore structure and drug-loading: Application for sciatic nerve regeneration

Cited by 21 publications

References 57 publications

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Water-responsive 4D printing based on self-assembly of hydrophobic protein “Zein” for the control of degradation rate and drug release

Fabrication of Zein‐Based Fibrous Scaffolds for Biomedical Applications—A Review

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