Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

Abstract

An electrical signal is the key basis of normal physiological function of the nerve, and the stimulation of the electric signal also plays a very special role in the repair process of nerve injury. Electric stimulation is shown to be effective in promoting axonal regeneration and myelination, thereby promoting nerve injury repair. At present, it is considered that electric conduction recovery is a key aspect of regeneration and repair of long nerve defects. Conductive neural scaffolds have attracted more and more attention due to their similar electrical properties and good biocompatibility with normal nerves. Herein, PCL and MXene-PCL nerve guidance conduits (NGCs) were prepared; their effect on nerve regeneration was evaluated in vitro and in vivo. The results show that the NGCs have good biocompatibility in vitro. Furthermore, a sciatic nerve defect model (15 mm) of SD rats was made, and then the fabricated NGCs were implanted. MXene-PCL NGCs show similar results with the autograft in the sciatic function index, electrophysiological examination, angiogenesis, and morphological nerve regeneration. It is possible that the conductive MXene-PCL NGC could transmit physiological neural electric signals, induce angiogenesis, and stimulate nerve regeneration. This paper presents a novel design of MXene-PCL NGC that could transmit self-originated electric stimulation. In the future, it can be combined with other features to promote nerve regeneration.

Conductive and Enhanced Mechanical Strength of Mo2Ti2C3 MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

“…Activation of the BDNF pathway is beneficial for activating bone marrow mesenchymal stem cells during radiation injury . Conductive MXene-PCL nerve guidance conduits could transmit physiological neural electric signals, induce angiogenesis, and stimulate nerve regeneration . Ti3 C2 Tx MXene enhances NSC neurogenesis and simultaneously tailors the cell growth direction to improve neural regeneration .…”

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

“…4F–L). 117 The MXene-PCL NGCs exhibited excellent biocompatibility, with no significant toxicity toward Schwann cells, good levels of cell attachment, and no abnormalities in major organs when postoperatively evaluated in rats at wk 12. The NGCs remained structurally intact but displayed some surface degradation, which did not affect their biocompatibility or levels of nerve regeneration.…”

Recent Advances in MXene-Based Fibers, Yarns, and Fabrics for Wearable Energy Storage Devices Applications

“…In addition, MXene material is also widely used in biology, , medicine, , electromagnetic shielding, , sensing, , temperature regulation, , human health monitoring, − and other fields. MXene-based fibers/fabrics not only are used to make single-function textiles but also can be prepared as multifunctional textiles, which can simultaneously have functions such as heating, energy storage, electromagnetic shielding, and sensing. − This multifunctional textile has an excellent prospect.…”