Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid

Heep, Graciela; Almeida, Andreia; Marcano, Rossana Gabriela Del Jesús Vásquez; Vieira, Daniele Gonçalves; Mainardes, Rubiana Mara; Khalil, Najeh Maissar; Sarmento, Bruno

doi:10.1016/j.ijbiomac.2019.07.030

Cited by 43 publications

(17 citation statements)

References 33 publications

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“…In addition, ferulic-acid-chitosan-PLGA nanoparticles achieved a sustained release pattern of ferulic acid following oral administration [301]. Ferulic-acid-assembled zein-casein-lysine nanoparticles were claimed to be an efficient oral formulation of ferulic acid offering better intestinal permeability, low toxicity, and sustained release profile [302]. Ethyl-oleate-containing nanostructured lipid carriers have been reported to improve the oral bioavailability of ferulic acid compared with ferulic acid-conjugated solid lipid nanoparticles [303].…”

Section: Ferulic Acidmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Ferulic Acidmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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“…to improve the chemical and physical stability of zein nanoparticles, such as the inclusion of caseinate (19,28), chitosan (27), pectin (29), pluronic F127 and lecithin (30), sodium deoxycholate ( 22), lysine and caseinate (31), hyaluronic acid (32), and others. In this study, we evaluated the ability of PEG as a stabilizer agent to obtain zein nanoparticles with high colloidal stability.…”

Section: Nanoparticles Obtaining and Characterizationmentioning

confidence: 99%

Polyethylene Glycol-Stabilized Zein Nanoparticles Containing Gallic Acid

Wiggers¹,

Fin²,

Khalil³

et al. 2022

Food Technol. Biotechnol. (Online)

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Research background. Gallic acid is a polyphenol presenting antioxidant and antitumor activities, however its use as a nutraceutical or drug is hindered by its low bioavailability. Zein is a natural protein found in corn and has been applied as nanoparticle for drug carrier. In this study, zein nanoparticles were obtained and stabilized with polyethylene glycol (PEG) as gallic acid carriers. Experimental approach. Nanoparticles were obtained by the liquid-liquid method and characterized in terms of mean size, polydispersity index, zeta potential, morphology, solid-state interactions, and encapsulation efficiency/drug loading. The stability of nanoparticles was evaluated in simulated gastrointestinal fluids and food simulants, and the antioxidant activity was determined by the scavenging of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Results and conclusions. Zein nanoparticles containing gallic acid were obtained and stabilized only in the presence of PEG. The optimal conditions originated nanoparticles with mean size <200 nm, low polydispersity index (<0.25) and negative zeta potential (20 mV). The gallic acid encapsulation efficiency was about 40 %, drug loading about 5 %, and the compound was encapsulated in an amorphous state. FTIR did not identify chemical interactions after gallic acid nanoencapsulation. Zein nanoparticles were more susceptible to release the gallic acid in gastric than intestinal simulated medium, however more than 50 % of drug content was protected from premature release. In food simulants, the gallic acid release from nanoparticles was prolonged and sustained. Moreover, the nanoencapsulation did not reduce the antioxidant activity of gallic acid. Novelty and scientific contribution. The results show the importance of PEG on the formation and properties of zein nanoparticles obtained by the liquid-liquid dispersion method. This study indicates PEG-stabilized zein nanoparticles are potential carriers for gallic acid delivery by the oral route to take advantage of its antioxidant properties and be applied both in the pharmaceutical and food industry.

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“…This technique may be used for the preparation of functional food, rich in nutraceuticals. Zein–casein–lysine protein nanoparticles were developed by Reference [ 104 ] to modulate the intestinal permeability of ferulic acid and to afford its sustained delivery.…”

Section: Novel Strategies For Ferulic Acid Drug Deliverymentioning

confidence: 99%

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Stompor-Gorący

Machaczka

2021

IJMS

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Trans-ferulic acid (FA) is a derivative of 4-hydroxycinnamic acid, which is found in many food products, fruits and beverages. It has scientifically proven antioxidant, anti-inflammatory and antibacterial properties. However, its low ability to permeate through biological barriers (e.g., the blood–brain barrier, BBB), its low bioavailability and its fast elimination from the gastrointestinal tract after oral administration limit its clinical use, e.g., for the treatment of neurodegenerative diseases, such as Alzheimer’s disease. Therefore, new nanotechnological approaches are developed in order to regulate intracellular transport of ferulic acid. The objective of this review is to summarize the last decade’s research on biological properties of ferulic acid and innovative ways of its delivery, supporting pharmacological therapy.

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Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid

Cited by 43 publications

References 33 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Polyethylene Glycol-Stabilized Zein Nanoparticles Containing Gallic Acid

Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

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