Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Stompor-Gorący, Monika; Machaczka, Maciej

doi:10.3390/ijms222312889

Cited by 52 publications

(33 citation statements)

References 107 publications

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“…Acting as an antioxidant, FA can inhibit the enzymes that lead to ROS formation, scavenge free radicals, and promote the antioxidant enzymes activity [ 372 ]. This makes FA a compound widely used in cosmetics and in food industry, especially as an anti-aging agent [ 377 ]. It has been demonstrated to protect skin from UV radiation through its capacity to reduce the activity of the stress-inducible protein Gadd45 α, the expression of MMP-1 and MMP-3 mRNAs, as well as enhancing the levels of the antioxidant enzymes SOD1 and CAT [ 326 , 378 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

et al. 2022

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Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial and protective in several physiological processes, an excessive senescent cell burden has been involved in various pathological conditions including aging, tissue dysfunction and chronic diseases. Oxidative stress (OS) can drive senescence due to a loss of balance between pro-oxidant stimuli and antioxidant defences. Therefore, the identification and characterization of antioxidant compounds capable of preventing or counteracting the senescent phenotype is of major interest. However, despite the considerable number of studies, a comprehensive overview of the main antioxidant molecules capable of counteracting OS-induced senescence is still lacking. Here, besides a brief description of the molecular mechanisms implicated in OS-mediated aging, we review and discuss the role of enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur compounds, nitrogen non-protein molecules, minerals, flavonoids, and non-flavonoids as antioxidant compounds with an anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

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Section: Resultsmentioning

confidence: 99%

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

et al. 2022

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“…Ferulic acid (FA), a hydroxycinnamic acid that is widely present in plant cell walls, has anti-microbial, antioxidant, and anti-inflammatory properties ( Stompor-Goracy and Machaczka, 2021 ). Mir et al (2018) demonstrated that FA suppressed inflammatory cytokines, increased antioxidant levels, and thus attenuated fibrosis and improved renal function in mice with LPS-induced AKI mediated by the NF-κB signaling pathway.…”

Section: Therapeutic Approaches In Sepsis-induced Acute Kidney Injurymentioning

confidence: 99%

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

Wang

Chen

et al. 2022

Front. Pharmacol.

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Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and severe complication of sepsis, and it is associated with high mortality and poor outcomes. Recent evidence has identified that autophagy participates in the pathophysiology of sepsis-associated AKI. Despite the use of antibiotics, the mortality rate is still at an extremely high level in patients with sepsis. Besides traditional treatments, many natural products, including phytochemicals and their derivatives, are proved to exert protective effects through multiple mechanisms, such as regulation of autophagy, inhibition of inflammation, fibrosis, and apoptosis, etc. Accumulating evidence has also shown that many pharmacological inhibitors might have potential therapeutic effects in sepsis-induced AKI. Hence, understanding the pathophysiology of sepsis-induced AKI may help to develop novel therapeutics to attenuate the complications of sepsis and lower the mortality rate. This review updates the recent progress of underlying pathophysiological mechanisms of sepsis-associated AKI, focuses specifically on autophagy, and summarizes the potential therapeutic effects of phytochemicals and pharmacological inhibitors.

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“…Many research findings have shown that FA plays an essential role as an antiinflammatory agent, suppressing the production of pro-inflammatory cytokines, promoting the production of anti-inflammatory cytokines, and increasing the expression of stress-responsive genes and antioxidant molecules like metallothioneins [19]. Moreover, this natural acid's anticancer effect is linked to its capacity to decrease reactive oxygen species, which shields cellular components from oxidative damage [20]. Furthermore, FA treatment of diabetic rats was observed to restore normal blood glucose and insulin levels [19].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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The incidence of many human disorders, such as cancer, oxidative stress, diabetes mellitus, and inflammatory diseases, has been mountingly increased because of many factors, including environmental pollution, static lifestyle, and unhealthy feeding. In an attempt to explore a scaffold with multiple biomedical activities, four natural phenolic acids, namely vanillic-, protocatechuic-, ferulic-, and caffeic-acid, were selected to construct twelve derived coumarins. The skeletal formulas of the semi-synthesized coumarins were confirmed by analyzing their spectra afforded via various spectrophotometers. The biomedical characteristics of these coumarins were investigated and included their antioxidant, anti-inflammatory, antidiabetic, and anticancer activities. The antioxidant activity was quantified by monitoring the potential of these coumarins to reduce DPPH and hydroxyl oxidants and provide an electron in the redox reaction. The anti-inflammatory activity was detected by specifying the inhibitory and selectivity of these coumarins on two COX isozymes. The antidiabetic activity was determined by examining the capacity of these coumarins to suppress two enzymes involved in blood glucose regulation. The anticancer activity and cytotoxicity were examined via MTT-based methodology versus four cancer cell lines and one normal cell line. The findings revealed that the semi-synthesized coumarins exhibited potent antioxidant and anticancer activities with low-induced cytotoxicity. Also, these coumarins showed modest antidiabetic potential and inhibitory effects versus the COX isozymes, with some selectivity toward the inhibition of COX-2. The authors concluded that these coumarins, specifically YC11, provide a valid structural template for synthesizing multi-functional agents effective in treating health situations in which oxidative stress, inflammation, diabetes, and cancer are combined.

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Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid

Cited by 52 publications

References 107 publications

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Sepsis-induced AKI: From pathogenesis to therapeutic approaches

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