ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1

Wang, Huifeng; Dong, Hui; Qiao, Lijiao; Wu, Yuanyuan; Wu, Bo; Jin, Xiangming

doi:10.1016/j.yexcr.2021.112687

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Functionally, ZEB1 is linked to tumor grade, metastasis and epithelial-to-mesenchymal transition in LC [16]. Mechanically, ZEB1 drives the development and metastasis of nonsmall cell LC by targeting miR-320a to upregulate RAD51AP1 expression [27]. In this study, we demonstrated that ZEB1 transcriptionally upregulates the expression of SKA3 and PLK1, contributing to LC progression.…”

Section: Discussionmentioning

confidence: 68%

Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle

Ning

Chen

et al. 2022

Anti-Cancer Drugs

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Lung cancer (LC) is one of the most common malignancies worldwide with low 5-year survival rate. The mechanism of spindle and kinetochore-associated complex subunit 3 (SKA3) in LC tumorgenesis remains largely unclear. The expression of SKA3 in LC cells was detected by quantitative PCR. Cell proliferation, migration and cell cycle were evaluated by functional assays including 5-ethynyl-2′-deoxyuridine, wound healing, transwell assays and flow cytometry analysis. Bioinformatics analysis, chromatin immunoprecipitation, luciferase reporter, co-immunoprecipitation and in vitro phosphorylation assays were applied to explore the interactions between zinc finger E-box binding homeobox 1 (ZEB1) and SKA3/polo-like kinase 1 (PLK1). SKA3 is highly expressed in LC cell lines and drives LC cell proliferation, migration and cell cycle. PLK1 also enhances the malignancy of LC cells. PLK1 can mediate SKA3 phosphorylation and enhance the stability of SKA3 protein, thus promoting LC progression. Besides, we found that transcription factor ZEB1 transcriptionally activates SKA3/PLK1 expression, contributing to LC cell malignancy. This study demonstrated that transcription factor ZEB1 modulates PLK1-mediated SKA3 phosphorylation to accelerate LC cell growth, migration and cycle, which might offer novel insight into LC treatment.

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Section: Discussionmentioning

confidence: 68%

Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle

Ning

Chen

et al. 2022

Anti-Cancer Drugs

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“…Conversely, miR-320a expression levels have been shown to be reduced in NSCLC tissues and cells. Zinc finger E-box binding homeobox 1 can inhibit the expression of miR-320a that contributes to the high expression level of RAD51AP1 to promote tumor growth and metastasis in NSCLC ( 18 ). Vitamin D may suppress metastasis of NSCLC cells by promoting apoptosis via the PI3K/AKT/mTOR signaling pathway ( 19 ).…”

Section: The Role Of Pcd In the Metastasis Of Nsclcmentioning

confidence: 99%

Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

Huang

Lou

et al. 2022

Exp Ther Med

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Non-small cell lung cancer (NSCLC), a common type of cancer worldwide, is normally associated with a poor prognosis. It is difficult to treat successfully as it often metastasizes into brain or bone. Methods to facilitate the induction of effective programmed cell death (PCD) in NSCLC cells to reverse drug resistance, or to inhibit the invasion and migration of NSCLC cells, are currently under investigation. The present study summarized the regulatory functions of PCD, including apoptosis, autophagy and ferroptosis, in the context of NSCLC metastasis. It further summarized how regulatory agents, including long non-coding RNAs, circular RNAs and microRNAs, regulate PCD during the metastasis of NSCLC and characterized new potential diagnostic biomarkers of NSCLC metastasis.

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ZEB1-activated Notch1 promotes circulating tumor cell migration and invasion in lung squamous cell carcinoma

2022

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ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1

Cited by 7 publications

References 27 publications

Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle

Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle

Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

ZEB1-activated Notch1 promotes circulating tumor cell migration and invasion in lung squamous cell carcinoma

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