Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

Xu, Lei; Huang, Xin; Lou, Yan; Xie, Wei; Zhao, Hangyu

doi:10.3892/etm.2022.11279

Cited by 9 publications

(3 citation statements)

References 119 publications

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“…During the past decades, there has been an accumulative research focus on the relationship between ferroptosis and diseases [ 75 , 76 ]. The significance of ferroptosis in cell survival and differentiation is widely accepted, and its regulatory role in the modulation and treatment of diverse disease has been gradually uncovered [ 77 , 78 ]. However, there are still some academic problems yet to be resolved.…”

Section: Discussionmentioning

confidence: 99%

The Regulatory Role of Ferroptosis in Bone Homeostasis

Xiong

Chen

Lin

et al. 2022

Stem Cells International

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Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

The Regulatory Role of Ferroptosis in Bone Homeostasis

Xiong

Chen

Lin

et al. 2022

Stem Cells International

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“…miRNAs are responsible for post-transcriptional gene regulation and are classified according to their oncogenic and tumor suppression functions in the regulation of diverse cell functions [ 1 ]. miRNAs are known to have several functions in the regulation of proliferation, apoptosis [ 2 ], autophagy [ 3 , 4 , 5 ], endoplasmic reticulum (ER) stress [ 1 , 6 ], ferroptosis [ 7 , 8 , 9 , 10 ], necroptosis [ 11 , 12 , 13 , 14 ], DNA damage response (DDR) [ 15 , 16 , 17 ], senescence [ 18 , 19 ], and migration [ 20 , 21 , 22 , 23 ] relating to cancer cells [ 23 , 24 , 25 ]. In the following, we briefly introduce the background for these cell functions and their relationships to miRNA.…”

Section: Introductionmentioning

confidence: 99%

“…Different miRNAs may exhibit functions opposite to apoptosis. Oncogenic miRNAs suppress cancer cell apoptosis, while tumor-suppressor miRNAs promote such apoptosis [ 2 ]. Autophagy refers to self-eating biomolecule recycling for energy restoration and abnormal organelle digestion of cells in response to starvation and other stressors.…”

Section: Introductionmentioning

confidence: 99%

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Shiau

Chuang

Yen

et al. 2023

IJMS

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Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.

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Apoptotic signaling pathways in bone metastatic lung cancer: a comprehensive analysis

Zhang,

Zheng,

Zhang

et al. 2024

Discov Onc

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This review provides a comprehensive analysis of apoptotic signaling pathways in the context of bone metastatic lung cancer, emphasizing the intricate molecular mechanisms and microenvironmental influences. Beginning with an overview of apoptosis in cancer, the paper explores the specific molecular characteristics of bone metastatic lung cancer, highlighting alterations in apoptotic pathways. Focused discussions delve into key apoptotic signaling pathways, including the intrinsic and extrinsic pathways, and the roles of critical molecular players such as Bcl-2 family proteins and caspases. Microenvironmental factors, such as the tumor microenvironment, extracellular matrix interactions, and immune cell involvement, are examined in depth. The review also addresses experimental approaches and techniques employed in studying apoptotic signaling, paving the way for a discussion on current therapeutic strategies, their limitations, and future prospects. This synthesis contributes a holistic understanding of apoptosis in bone metastatic lung cancer, offering insights for potential therapeutic advancements.

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Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

Cited by 9 publications

References 119 publications

The Regulatory Role of Ferroptosis in Bone Homeostasis

The Regulatory Role of Ferroptosis in Bone Homeostasis

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Apoptotic signaling pathways in bone metastatic lung cancer: a comprehensive analysis

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