Yoyo Bitters, a polyherbal formulation influenced some biochemical parameters in Wistar rats

Adeyemi, Oluyomi Stephen; Fambegbe, Moyinoluwa; Daniyan, Oluwasegun Richard; Nwajei, Irene

doi:10.1515/jbcpp-2012-0026

Cited by 28 publications

(29 citation statements)

References 8 publications

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“…Alteration in body weight and/or organ to body weight ratio has been shown to imply toxicity arising from exposure to a toxicant [24, 25]. No appreciable weight change was recorded for all treatment groups.…”

Section: Discussionmentioning

confidence: 99%

Moringa oleiferaSupplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

Adeyemi

Elebiyo

2014

Journal of Nutrition and Metabolism

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Background. The Moringa oleifera plant has been implicated for several therapeutic potentials. Objective. To evaluate whether addition of M. oleifera to diet has protective effect against nickel-induced nephrotoxicity in rats. Methodology. Male Wistar rats were assigned into six groups of five. The rats were given oral exposure to 20 mg/kg nickel sulphate (NiSO4) in normal saline and sustained on either normal diet or diets supplemented with Moringa oleifera at different concentrations for 21 days. 24 hours after cessation of treatments, all animals were sacrificed under slight anesthesia. The blood and kidney samples were collected for biochemical and histopathology analyses, respectively. Results. NiSO4 exposure reduced the kidney-to-body weight ratio in rats and caused significant elevation in the levels of plasma creatinine, urea, and potassium. Also, the plasma level of sodium was decreased by NiSO4 exposure. However, addition of M. oleifera to diets averted the nickel-induced alteration to the level of creatinine and urea. The histopathology revealed damaged renal tubules and glomerular walls caused by NiSO4 exposure. In contrast, the damages were ameliorated by the M. oleifera supplemented diets. Conclusion. The addition of M. oleifera to diet afforded significant protection against nickel-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Moringa oleiferaSupplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

Adeyemi

Elebiyo

2014

Journal of Nutrition and Metabolism

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“…Such certification would need to be disseminated to the general populace, through mass media and public enlighten programmes. Although, animal studies were undertaken on the safety of Jobelyn® and Yoyo cleanser bitters® when used at recommended doses32,33, a randomised clinical trial is required in human to corroborate this claim.…”

Section: Discussionmentioning

confidence: 99%

Herbal medicines supplied by community pharmacies in Lagos, Nigeria: pharmacists´ knowledge

Oshikoya

Oreagba

Ogunleye

et al. 2013

Pharmacy Practice (Internet)

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BackgroundThe use of herbal medicines is on the increase globally and they are usually supplied in pharmacies as non-prescription medicines. Pharmacists are, therefore, responsible for educating and informing the consumers about rational use of herbal medicines.ObjectiveTo evaluate the knowledge of pharmacists in Lagos, Nigeria with regards to the herbal medicines they supplied by their pharmacies.MethodsPharmacists in charge of randomly selected 140 community pharmacies from 20 Local Government Areas in Lagos were required to fill out a self-administered questionnaire. We gathered information on their knowledge of the indications, adverse effects, potential drug-herb interactions and contraindications of the herbal medicines they supply in their pharmacies.ResultsOf the 140 questionnaires distributed, 103 (72.9%) participants completed the questionnaire appropriately. The majority (74; 71.8%) of the participants were males and 36-50 years (56; 54.4%). The pharmacies supplied mostly Yoyo cleanser bitters® (101; 98.5%), ginseng (97; 98.5%), Jobelyn® (91; 88.3%), Ciklavit® (68; 66.6%), gingko (66; 64.1%), herbal tea (66; 64.1%), and Aloe vera (57; 55.3%). The pharmacists self-rated their knowledge of herbal medicines mostly as fair (39%) and good (42%), but they exhibited poor knowledge with regards to the indications, contraindications and safety profiles. Seventy participants consulted reference materials such as leaflet insert in the herbal medicines (56%) and internet (20%) before supplying herbal medicines. The information most frequently sought was herb-drug interactions (85%), contraindications (75%) and adverse effects (70%).ConclusionsCommunity pharmacists need to be informed about the indications and safety profiles of herbal medicines.

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“…However, recent studies have demonstrated the need to subject some of the herbal preparations through a scientific validation process to ascertain their health benefits [7,8]. Therefore, this study was designed to evaluate the antioxidant and anti-inflammatory properties of the abovementioned polyherbal preparation: Oroki herbal, Swedish bitters and Yoyo bitters with the rationale to proffer a scientific explanation for the local use of these formulations.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of selected polyherbal preparations: Oroki herbal, Swedish bitters and Yoyo bitters

Anyasor¹,

Ogunbiyi²,

Akinlusi³

2017

Oxid Antioxid Med Sci

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Yoyo Bitters, a polyherbal formulation influenced some biochemical parameters in Wistar rats

Abstract: In light of this, caution and adherence to dosage prescription is strongly advised. This study is a contribution to scientific knowledge on the safety/toxicity profile of Yoyo Bitters among the growing list of Nigerian herbal remedies.

Cited by 28 publications

References 8 publications

Moringa oleiferaSupplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

Moringa oleiferaSupplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

Herbal medicines supplied by community pharmacies in Lagos, Nigeria: pharmacists´ knowledge

Antioxidant and anti-inflammatory properties of selected polyherbal preparations: Oroki herbal, Swedish bitters and Yoyo bitters

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