Moringa oleiferaSupplemented Diets Prevented Nickel-Induced Nephrotoxicity in Wistar Rats

Abstract

Background. The Moringa oleifera plant has been implicated for several therapeutic potentials. Objective. To evaluate whether addition of M. oleifera to diet has protective effect against nickel-induced nephrotoxicity in rats. Methodology. Male Wistar rats were assigned into six groups of five. The rats were given oral exposure to 20 mg/kg nickel sulphate (NiSO4) in normal saline and sustained on either normal diet or diets supplemented with Moringa oleifera at different concentrations for 21 days. 24 hours after cessation of treatments, all animals were sacrificed under slight anesthesia. The blood and kidney samples were collected for biochemical and histopathology analyses, respectively. Results. NiSO4 exposure reduced the kidney-to-body weight ratio in rats and caused significant elevation in the levels of plasma creatinine, urea, and potassium. Also, the plasma level of sodium was decreased by NiSO4 exposure. However, addition of M. oleifera to diets averted the nickel-induced alteration to the level of creatinine and urea. The histopathology revealed damaged renal tubules and glomerular walls caused by NiSO4 exposure. In contrast, the damages were ameliorated by the M. oleifera supplemented diets. Conclusion. The addition of M. oleifera to diet afforded significant protection against nickel-induced nephrotoxicity.

Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview

“…These findings were confirmed by histological examinations, which revealed an amelioration of the hepatic and kidney damages induced by drugs, in animals treated with Moringa oleifera leaves. Similar results were obtained by Adeyemi and Elebiyo [ 162 ] in rats co-treated with Moringa oleifera leaves and NiSO 4 in order to induce nephrotoxicity. Finally, Das et al [ 123 ] observed a reduction of ALT, AST and ALP and a lower liver damage in rats fed with high fat diet and co-treated with Moringa oleifera leaves, suggesting a potential role of the leaves in the prevention of nonalcoholic fatty liver disease (NAFLD).…”

Assessment of the Potential Role of L- Methionine on Nickel Sulfate Induced Renal Injury and Oxidative Stress in Rat

“…Our results were in accordance with those reported by Amudha and Pari [2], who mentioned a significant increase in the relative kidney weight in Nitreated male rats. However, our results were opposing those reported by Dahmen-Ben Moussa et al [21] and Adeyemi and Elebiy [20] who exhibited that Ni treatment resulted in a significant decrease in relative kidney weight. In the present work, coadministration of methionine prevented changes in relative kidney weight and body weights.…”

“…animal growth and increase in organ-somatic index [19,20]. Our results were in accordance with those reported by Amudha and Pari [2], who mentioned a significant increase in the relative kidney weight in Nitreated male rats.…”

“…Likewise, Hfaïedh et al [28] and Boulila et al [5] as they noted increased creatinine and urea due to nickel and reflects its interaction with the cell membrane. Our results are also analogous to the findings of Chen et al [29] and Adeyemi and Elebiyo [20].…”

Grow Moringa (Moringa oleifera), the miracle tree on the earth

“…The leaf extracts have shown to decrease the acetylcholine esterase activity, thereby improving cholinergic function and memory. 36 Adeyemi et al, 37 showed that moringa in diet can increase protein content and decrease levels of urea and creatinine in blood, preventing renal dysfunction. Moringa decreased acidity in gastric ulcers by a percentage of 86.15 and 85.13 at doses of 500mg and 350mg, respectively and therefore can be used as an antiulcer agent.…”