Yogurt-sourced probiotic bacteria alleviate shrimp tropomyosin-induced allergic mucosal disorders, potentially through microbiota and metabolism modifications

Fu, Linglin; Fu, Shujie; Wang, Chong; Xie, Menghua; Li, Han

doi:10.1016/j.alit.2019.05.013

Cited by 23 publications

(24 citation statements)

References 42 publications

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“…Our data further suggest that the absence of IL-33/ST2 signaling may hinder the role of OVA, which is also a contribution of Bb M-16V. Some studies have presented similar conclusions in other antigen-specific mouse models (De GroveTeufelberger et al, 2018).Second, many studies have shown that the FA are accompanied by the dysbiosis in recent years(Fu, Fu, Wang, Xie, & Wang, 2019;Ly, Litonjua, Gold, & Celedon, 2011). We have identified the changes of dynamic dysbiotic in the intestinal flora of FA mice induced by OVA, evidenced by the failure of gut microbiota of mice with FA to protect against FA.…”

supporting

confidence: 78%

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Bifidobacterium breve M‐16V alters the gut microbiota to alleviate OVA‐induced food allergy through IL‐33/ST2 signal pathway

Chen

et al. 2020

Journal Cellular Physiology

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There has been a marked increase in life‐threatening food allergy (FA). One hypothesis is that changes in bacterial communities may be key to FA. To better understand how gut microbiota regulates FA in humans, we established a mouse model with FA induced by ovalbumin. We found that the mice with FA had abnormal bacterial composition, accompanied by increased immunoglobulin G, immunoglobulin E, and interleukin‐4/interferon‐γ, and there existed a certain coherence between them. Interestingly, Bifidobacterium breve M‐16V may alter the gut microbiota to alleviate the allergy symptoms by IL‐33/ST2 signaling. Our results indicate that gut microbiota is essential for regulating FA to dietary antigens and demonstrate that intervention in bacterial community regulation may be therapeutically related to FA.

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supporting

confidence: 78%

“…Second, many studies have shown that the FA are accompanied by the dysbiosis in recent years (Fu, Fu, Wang, Xie, & Wang, 2019;Ly, Litonjua, Gold, & Celedon, 2011). We have identified the changes of previous studies.…”

Section: Quantification and Statistical Analysismentioning

confidence: 93%

Bifidobacterium breve M‐16V alters the gut microbiota to alleviate OVA‐induced food allergy through IL‐33/ST2 signal pathway

Chen

et al. 2020

Journal Cellular Physiology

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“…Bifidobacterium lactis was found to increase the ratio of Treg and Th17 cells in a mouse model. Other studies have found Bifidobacterium longum and Bacillus coagulans to regulate gut dysbiosis and mitigate overactive Th2 response in tropomyosin-induced allergic mice [89]. Bifidobacterium longum and Bacillus coagulans have also found to regulate gut arginine metabolism pathways, leading to the conclusion that metabolites of aspartate and arginine may be critical for prevention of food allergy.…”

Section: Crustacean and Molluscan Shellfishmentioning

confidence: 98%

The Gut Microbiome and the Big Eight

et al. 2020

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Food allergies are increasing at an alarming rate, with 6.5% of the general population affected. It has been hypothesized that the increase in allergies stems from the “hygiene hypothesis”. The gut microbiome, a collection of microbiota and their genetic contents from the gastrointestinal tract, has been shown to play a part in the development of food allergies. The Food and Drug Administration requires all regulated food companies to clearly state an inclusion of the major, or “big eight” food allergens on packaging. This review is to provide information on the significant advancements related to the gut microbiome and each of the eight major food allergies individually. Establishment of causal connection between the microbiome and food allergies has uncovered novel mechanisms. New strategies are discussed to prevent future sensitization and reaction through novel treatments involving functional additives and dietary changes that target the microbiome.

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“…Probiotics, in general, have therefore emerged as potential alternative therapeutics in the past decade. Current knowledge suggests that the oral administration of probiotics may contribute to antigen modification, repair of gut barrier function, restoration of gut microbiota, and systemic immune regulation (Nermes et al, 2013;Samak and Rao, 2013;Bunyavanich et al, 2016;Fu et al, 2019;Joseph et al, 2021). To date, the anti-allergic mechanism of probiotic treatment has not been fully elucidated, thus limiting further clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Pediococcus acidilactici Strain Alleviates Gluten-Induced Food Allergy and Regulates Gut Microbiota in Mice

Chen

Xie

et al. 2022

Front. Cell. Infect. Microbiol.

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Wheat flour, the most important source of food globally, is also one of the most common causative agents of food allergy. Wheat gluten protein, which accounts for 80% of the total wheat protein, is a major determinant of important wheat-related disorders. In this study, the effects of Pediococcus acidilactici XZ31 against gluten-induced allergy were investigated in a mouse model. The oral administration of P. acidilactici XZ31 attenuated clinical and intestinal allergic responses in allergic mice. Further results showed that P. acidilactici XZ31 regulated Th1/Th2 immune balance toward Th1 polarization, which subsequently induced a reduction in gluten-specific IgE production. We also found that P. acidilactici XZ31 modulated gut microbiota homeostasis by balancing the Firmicutes/Bacteroidetes ratio and increasing bacterial diversity and the abundance of butyrate-producing bacteria. Specifically, the abundance of Firmicutes and Erysipelotrichaceae is positively correlated with concentrations of gluten-specific IgE and may act as a fecal biomarker for diagnosis. The evidence for the role of P. acidilactici XZ31 in alleviating gluten-induced allergic responses sheds light on the application of P. acidilactici XZ31 in treating wheat allergy.

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Yogurt-sourced probiotic bacteria alleviate shrimp tropomyosin-induced allergic mucosal disorders, potentially through microbiota and metabolism modifications

Cited by 23 publications

References 42 publications

Bifidobacterium breve M‐16V alters the gut microbiota to alleviate OVA‐induced food allergy through IL‐33/ST2 signal pathway

Bifidobacterium breve M‐16V alters the gut microbiota to alleviate OVA‐induced food allergy through IL‐33/ST2 signal pathway

The Gut Microbiome and the Big Eight

Pediococcus acidilactici Strain Alleviates Gluten-Induced Food Allergy and Regulates Gut Microbiota in Mice

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