The Gut Microbiome and the Big Eight

Suther, Cassandra; Moore, Matthew D.; Beigelman, Avraham; Zhou, Yanjiao

doi:10.3390/nu12123728

Cited by 23 publications

(19 citation statements)

References 101 publications

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“…SCFA are mainly produced in the large intestine and are used as an energy source by colonocytes. In addition, they play an important role in keeping pathogenic bacteria under control and maintaining intestinal integrity and health [171][172][173]. A proportion of these SCFA is absorbed by the portal vein, carried to the liver, metabolized, and then systemically distributed via the bloodstream.…”

Section: Effects Of Fatty Acids (Fa) and Vitamins On Epigenetic Signa...mentioning

confidence: 99%

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

et al. 2021

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Epidemiological studies have shown a dramatic increase in the incidence and the prevalence of allergic diseases over the last several decades. Environmental triggers including risk factors (e.g., pollution), the loss of rural living conditions (e.g., farming conditions), and nutritional status (e.g., maternal, breastfeeding) are considered major contributors to this increase. The influences of these environmental factors are thought to be mediated by epigenetic mechanisms which are heritable, reversible, and biologically relevant biochemical modifications of the chromatin carrying the genetic information without changing the nucleotide sequence of the genome. An important feature characterizing epigenetically-mediated processes is the existence of a time frame where the induced effects are the strongest and therefore most crucial. This period between conception, pregnancy, and the first years of life (e.g., first 1000 days) is considered the optimal time for environmental factors, such as nutrition, to exert their beneficial epigenetic effects. In the current review, we discussed the impact of the exposure to bacteria, viruses, parasites, fungal components, microbiome metabolites, and specific nutritional components (e.g., polyunsaturated fatty acids (PUFA), vitamins, plant- and animal-derived microRNAs, breast milk) on the epigenetic patterns related to allergic manifestations. We gave insight into the epigenetic signature of bioactive milk components and the effects of specific nutrition on neonatal T cell development. Several lines of evidence suggest that atypical metabolic reprogramming induced by extrinsic factors such as allergens, viruses, pollutants, diet, or microbiome might drive cellular metabolic dysfunctions and defective immune responses in allergic disease. Therefore, we described the current knowledge on the relationship between immunometabolism and allergy mediated by epigenetic mechanisms. The knowledge as presented will give insight into epigenetic changes and the potential of maternal and post-natal nutrition on the development of allergic disease.

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Section: Effects Of Fatty Acids (Fa) and Vitamins On Epigenetic Signa...mentioning

confidence: 99%

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

et al. 2021

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“…Bifidobacterium levels in the gut have been reported to be inversely correlated with inflammation in disease models [1]. The bacteria itself is thought to exhibit anti-inflammatory properties [20].…”

Section: Discussionmentioning

confidence: 99%

“…The gut microbiome, a collection of microbiota and their genetic contents from the gastrointestinal tract, has been shown to play an important part in health [1,2]. Gut microbiome dysbiosis is thought to be linked to the development of disease and weight gain [1,3]. Diet has a profound effect on the configuration of the gut microbiome.…”

Section: Introductionmentioning

confidence: 99%

Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models

et al. 2022

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Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. Akkermansia muciniphila, associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, along with an increase in Bifidobacterium in female mice. Akkermansia muciniphila and Bifidobacterium were plated on media containing varying levels of AKBA (0%, 0.001%, 0.01%, and 0.1%). All concentrations of AKBA completely inhibited growth of Akkermansia muciniphila but had no effect on Bifidobacterium. Several blood metabolites differed with AKBA between both males and females. These results show the potential benefits of dietary Boswellia serrata on the modulation of gut microbiome composition, along with differences between sexes.

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“…For example, the incidence of peanut allergy is not highly prevalent in the Southeast Asia population compared to Western countries, while the incidence of allergy towards cashew nuts was observed to be comparatively higher among children from the Southeast Asia region [18][19][20]. Nonetheless, the main allergens remain largely true to most parts of the world, with eggs, milk, fish, and shellfish being the top four main food allergens, while peanuts, tree nuts, soybeans and wheat are the next four items, thus completing "the big eight" common food allergens [21][22][23].…”

Section: Disease Management and Current Clinical Challengesmentioning

confidence: 99%

The Interplay of Nutriepigenomics, Personalized Nutrition and Clinical Practice in Managing Food Allergy

Ali

Hamzaid

Ismail

2021

Life

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Food allergy in children has been a common issue due to the challenges of prescribing personalized nutrition with a lack of nutriepigenomics data. This has indeed further influenced clinical practice for appropriate management. While allergen avoidance is still the main principle in food allergy management, we require more information to advance the science behind nutrition, genes, and the immune system. Many researchers have highlighted the importance of personalized nutrition but there is a lack of data on how the decision is made. Thus, this review highlights the relationship among these key players in identifying the solution to the clinical management of food allergy with current nutriepigenomics data. The discussion integrates various inputs, including clinical assessments, biomarkers, and epigenetic information pertaining to food allergy, to curate a holistic and personalized approach to food allergy management in particular.

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The Gut Microbiome and the Big Eight

Cited by 23 publications

References 101 publications

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models

The Interplay of Nutriepigenomics, Personalized Nutrition and Clinical Practice in Managing Food Allergy

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