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Mavlyanov, S. M.; Islambekov, Sh. Yu.; Исмаилов, А. И.; Dalimov, D. N.; Abdulladzhanova, N. G.

doi:10.1023/a:1017605223089

Cited by 24 publications

(4 citation statements)

References 54 publications

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“…These data provide evidence that Rhus coriaria extract accelerates cutaneous wound healing through decreasing MPO activity and oxidative damage in both infected and noninfected skin wounds. Previously, it was reported that Sumac leaves are good sources of phenolic acids and several flavonoids used frequently against many diseases as anti-inflammatory, antioxidant, antibacterial, fungicide, antiviral, and candidicide [59, 60].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

Gabr

Alghadir

2019

Evidence-Based Complementary and Alternative Medicine

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Impaired wound healing was mainly associated with severe microbial infections which significantly affect diagnostic and therapeutic strategies. Thus, in this study, the potential wound healing activity, anti-inflammatory, and antimicrobial activity of an aqueous extract of Rhus coriaria extract (AERc) were evaluated by wound contraction, scar formation, period of epithelization, MPO enzyme activity, collagenase-2 (MMP-8), hydroxyproline (HPX), and collagen deposition as markers of wound healing at different days of postwound. Phytoconstituents, microbial activity, and fibrogenic markers were screened by HPLC, disc-diffusion, and colorimetric assays. The animals were treated with Rhus coriaria extract (AERc) concentrations at doses of 5 mg.kg−1and 10 mg.kg−1, respectively. On days 6 and 9, the AERc-treated animals at doses of 5 mg.mL−1 and 10 mg.mL−1 exhibited a significant reduction in the wound area, increased deposition of collagen, HPX, and reduction in MMP-8, and MPO enzyme activity when compared with controls. Scar formation and epithelization were completed in 10 days compared to controls. In addition, in wounds infected separately with Staph. aureus or P. aeruginosa, the AERc extract significantly improved wound contraction, deposition of collagen, and HPx and reduced MMP-8 and MPO concentrations, with complete epithelization of wounds in 10-13 days compared to the saline-treated group. Hydrolyzable tannins, gallic acid, quercetin, and myricetin were the most common active components of AERc. In vitro, the AERc and its components were effective against a set of microbes especially Staph. aureus, P. aeruginosa, and Staph. aureus (MRSA). In conclusion, the results showed that antimicrobial, anti-inflammatory, and antioxidant activity of Rhus coriaria extract suggested its importance as a target for formulation of novel drugs against many microbial infections with minimal side effects and could play a good potential role in accelerating wound healing activity via promoting myofibroblast activity, increase of hydroxyproline and collagen deposition, and regulation of MMP-8 and MPO enzyme activities.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

Gabr

Alghadir

2019

Evidence-Based Complementary and Alternative Medicine

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“…oligomerization. Tannins, plant polyphenols, are divided into 2 groups, hydrolysable and condensed (proanthocyanidin) [12,13]. They exhibit a wide spectrum of biological activity, acting as antioxidants, antimicrobials, antitumor and antimutagenic drugs [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Interaction of α-synuclein with Rhus typhina tannin – Implication for Parkinson’s disease

Sękowski

Йонов

Abdulladjanova

et al. 2017

Colloids and Surfaces B: Biointerfaces

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The etiology of Parkinson's disease (PD) relates to α-synuclein, a small protein with the ability to aggregate and form Lewy bodies. One of its prevention strategies is inhibition of α-synuclein oligomerization. We have investigated the interaction of α-synuclein and human serum albumin with 3,6-bis-О-di-О-galloyl-1,2,4-tri-О-galloyl-β-d-glucose (a tannin isolated from the plant Rhus typhina). Using fluorescence spectroscopy method we found that this tannin interacts strongly with α-synuclein forming complexes. Circular dichroism analysis showed a time-dependent inhibition of α-synuclein aggregation in the presence of the tannin. On the other hand, 3,6-bis-О-di-О-galloyl-1,2,4-tri-О-galloyl-β-d-glucose had a much stronger interaction with human serum albumin than α-synuclein. The calculated binding constant for tannin-protein interaction was considerably higher for albumin than α-synuclein. This tannin interacted with albumin through a "sphere of action" mechanism. The results lead to the conclusion that 3,6-bis-О-di-О-galloyl-1,2,4-tri-О-galloyl-β-d-glucose is a potent preventive compound against Parkinson's disease. However, this tannin interacts very strongly with human serum albumin, significantly reducing the bioavailability of this compound.

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“…Furthermore, their presence can determine inhibitory conditions for biomass in biological treatment. Therefore, they are not completely degraded by the traditional wastewater treatment processes, leading to COD values that exceed the limits imposed by law [6,12,13].…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Photodegradation for the Abatement of Recalcitrant COD in Synthetic Tanning Wastewater

et al. 2022

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Tannery wastewater is considered one of the most contaminated and problematic wastes since it consists of considerable amounts of organic and inorganic compounds. These contaminants result in high chemical oxygen demand (COD), biochemical oxygen demand (BOD), and total suspended solids (TSS). In this work, the heterogeneous photodegradation of recalcitrant COD in wastewater from the tanning industry was investigated, in particular the recalcitrant COD due to the presence of vegetable tannins extracted from mimosa and chestnut and from synthetic tannins based on 4,4′ dihydroxy phenyl sulfone. TiO2 Aeroxide P-25 was employed to study the photodegradation of model molecules in batch conditions under different parameters, namely initial concentration of COD, temperature, and catalyst dose. The maximum COD abatement reached was 60%. Additionally, preliminary kinetic investigation was conducted to derive the main kinetic parameters that can be useful for process scale-up. It was found to be independent of the temperature value but linearly dependent on both catalyst loading and the initial COD value.

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Untitled

Cited by 24 publications

References 54 publications

Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

Interaction of α-synuclein with Rhus typhina tannin – Implication for Parkinson’s disease

Heterogeneous Photodegradation for the Abatement of Recalcitrant COD in Synthetic Tanning Wastewater

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