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Backensfeld, Thomas; Müller, Bernd W.; Wiese, M. V.; Seydel, Joachim K.

doi:10.1023/a:1015860531565

Cited by 45 publications

(11 citation statements)

References 4 publications

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“…Complexes with indomethacin were formed to test the effect of ring size of various cyclodextrin derivatives on IND stability. α, γ and β-CD were used to show that β-CD demonstrated the strongest influence on the stability compared to other derivatives, while α-CD caused a much faster degradation of indomethacin [25]. Research confirms that β-cyclodextrin has the most appropriate cavity size for IND, which may result in better stability and even increase solubility, as was observed in previous studies of indomethacin in a liquid state.…”

Section: Introductionsupporting

confidence: 63%

Preparation and Characterization of Indomethacin Supramolecular Systems with β-Cyclodextrin in Order to Estimate Photostability Improvement

Jamrógiewicz

Józefowicz

2021

Molecules

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Cyclodextrins have found wide application in contemporary chemistry, pharmacy and medicine. Because of their unique properties, cyclodextrins are constantly used in research on solubility or stability improvement, as well as other physicochemical properties of medicinal substances. Indomethacin (IND) is a photolabile molecule that also attracts the interest of researchers due to its therapeutic potential and the need to overcome its problematic photosensitivity. Supramolecular complexes of indomethacin with β-cyclodextrin (CD) are already known, and they show greater stability compared to complexes with other types of cyclodextrins. So far, however, the sensitivity to light of physical mixtures and inclusion complexes in the solid phase has not been studied, and their various stoichiometries have not yet been investigated. Due to this fact, the aim of the present study is to obtain supramolecular systems (inclusion complexes and physical mixtures) of indomethacin with three different amounts of β-cyclodextrin. Assessment of the photochemical stability of indomethacin-β-cyclodextrin systems in the solid state is performed in order to find the best correlation between IND stability and the amount of CD. Comparative analysis of physicochemical degradation for stoichiometry systems [CD:IND] = [1:1], [0.5:1] and [0.1:1] is performed by using ultraviolet spectroscopy, transmission—FTIR, reflection—ATR-FTIR infrared spectroscopy and DSC calorimetry.

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Section: Introductionsupporting

confidence: 63%

Preparation and Characterization of Indomethacin Supramolecular Systems with β-Cyclodextrin in Order to Estimate Photostability Improvement

Jamrógiewicz

Józefowicz

2021

Molecules

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“…For example, our technique allows us to develop a new way of producing monodisperse polymer-based microcapsules. In fact, sophisticated techniques [33][34][35][36][37][38][39][40], including coacervation phase separation, interfacial polymerization, solvent evaporation, spray coating, multiorifice centrifugal process, and air suspension, have been developed to produce polymer microcapsules. However, the microcapsules produced by using these approaches have polydisperse size distributions.…”

Section: Encapsulationsmentioning

confidence: 99%

Monodisperse polymer particles synthesized by seeded polymerization techniques

Kim

Suh

2008

Journal of Industrial and Engineering Chemistry

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“…The complex of indomethacin with CDs has been well studied 19-22 in solution and in the solid state 13,19,20. It accomplishes a 1:1 inclusion complex with β-CD or HP-β-CD 22 by inserting either the p-chlorobenzoic portion or the indole unit of the molecule into the CD cavity 23-25. In addition, inclusion complexes of indomethacin with β-CD or HP-β-CD were prepared and evaluated in vivo 21,22.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, inclusion complexes of indomethacin with β-CD or HP-β-CD were prepared and evaluated in vivo 21,22. These inclusion complexes have the ability to reduce gastrointestinal adverse effects 23,24.…”

Section: Introductionmentioning

confidence: 99%

Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats

Alsarra¹,

Ahmed²,

Alanazi³

et al. 2010

Int. J. Med. Sci.

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The aim of this work was to study the ability of β-cyclodextrin (β-CD) or hydroxypropyl β-cyclodextrin (HP-β-CD) to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug, indomethacin or piroxicam, in rats exposed to restraint and hypothermic stress at 4 °C. Using oral gavage, rats fasted for 72 h were administered the equivalent of a 100 mg/kg dose of the assigned drug, alone or with the designated cyclodextrin (CD). The rats were placed in suitable rodent restrainers and then placed inside a ventilated refrigerator maintained at a temperature of 4 °C. Six hours later, each animal was removed, anaesthetized with ether, and the abdomen opened. Each stomach was removed, opened along the greater curvature and gently rinsed with isotonic saline solution. The induced gastric ulcers were examined and assessed with the help of a 10x binocular magnifier. Pronounced and marked gastric ulceration with complete loss of the mucosa, extensive deposition of fibrin and dense neutrophilic infiltrate were observed in rats treated with each of the drugs alone. Treatment with indomethacin or piroxicam alone induced ulcer indices of 26 ± 2.3 or 14 ± 1.8, respectively. However, β-CD and HP-β-CD each significantly suppressed ulceration due to restraint and cold stress. Rats treated with indomethacin or piroxicam in the presence of either β-CD or HP-β-CD exhibited normal tissues. Therefore, β-CD and HP-β-CD act as protective agents against gastrointestinal disorders produced by restraint and cold stress, even with the added stress from administration of either indomethacin or piroxicam.

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Cited by 45 publications

References 4 publications

Preparation and Characterization of Indomethacin Supramolecular Systems with β-Cyclodextrin in Order to Estimate Photostability Improvement

Preparation and Characterization of Indomethacin Supramolecular Systems with β-Cyclodextrin in Order to Estimate Photostability Improvement

Monodisperse polymer particles synthesized by seeded polymerization techniques

Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats

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