Monodisperse polymer particles synthesized by seeded polymerization techniques

Kim, Jinwoong; Suh, Kyung‐Do

doi:10.1016/j.jiec.2007.06.001

Cited by 60 publications

(18 citation statements)

References 62 publications

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“…The above described one-pot Dis.P was basically dissimilar to a seeded polymerization in which pre-synthesized, linear polymer, spherical particles were used, swollen with a monomer/ cross-linker mixture, and then undergone polymerization. In the seeded polymerization, usually, the linear seed particles are uniformly and fully swollen at first [39][40][41] and then rapidly, homogeneously cross-linked, producing monodisperse large spherical particles with interpenetrating network (IPN) structure [13,14,28]. The rapid crosslinking and formation of IPN hinder phase separation of the seed particles [13].…”

Section: Resultsmentioning

confidence: 99%

“…In thermodynamic aspect, the cross-linking and swelling of growing particles correlated closely with the free energy (ΔG m; p ) [13,14,39,40] of hydrophobic monomers (St, DVB) and oligomers within growing particles. The crosslinking of growing particles made a positive, prominent contribution to ΔG m; p .…”

Section: Analyses For Formation Of Anisotropic Particlesmentioning

confidence: 94%

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Facile synthesis of core-shell, multiple compartment anisotropic particles via control of cross-linking and continuous phase separations in one-pot dispersion polymerization

et al. 2014

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Preparation of anisotropic particles based on phase separation of prefabricated seeds in polymerizations generally involves multiple process steps. In conventional one-pot dispersion polymerization, only spherical particles are produced. Herein, anisotropic particles with asymmetrical core-shell structure, multiple compartments, and continuously tunable surface roughness and sizes were synthesized by a modified one-pot dispersion polymerization. A mixture of polar solvents, ethylene glycol (EG), and water (6/4, vol.) was used as medium for polymerization of styrene (St). In the presence of ammonium persulfate (APS) and vinyl acetate (VA), divinylbenzene (DVB, 16.1-66.4 %) and (St, 50.3-0 %) were added at 60, 180, and 360 min, respectively. Dense crosslinking was confined to exterior of swollen growing particles, resulting in phase separation and formation of snowman-like particles with coarse, core-shell structured body, and smooth, no or partially cross-linked head. The newly formed compartments were also inhomogeneously cross-linked and their phases separated, producing three and four compartment anisotropic particles with an aspect ratio up to 2.3. Gel content of final particles was less than 75 %. Due to a sequential crosslinking from growing particle to newly formed compartments, reaction stability and particle monodispersity were maintained even when high amounts of DVB were added. Asymmetrical morphologies, structures, sizes, and surface roughness of particles were continuously tuned by varying DVB amount and its start addition time. This one-pot method provides a simple, efficient route for synthesis of anisotropic particles.

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Section: Resultsmentioning

confidence: 99%

Section: Analyses For Formation Of Anisotropic Particlesmentioning

confidence: 94%

Facile synthesis of core-shell, multiple compartment anisotropic particles via control of cross-linking and continuous phase separations in one-pot dispersion polymerization

et al. 2014

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“…[35][36][37] The key role in the formation of micro-and nanoparticles is played by the choice of their production technique. Currently, such carriers can be prepared using a variety of methods: electrohydrodynamic techniques, [38][39][40][41] microfluidic method, 42,43 coacervation [44][45] ; polymerization of monomers, 46 emulsification of solutions (two-and three-component emulsions with evaporation or diffusion of the solvent); [47][48][49] spray drying of solutions [50][51][52] etc. With regard to the preparation of PHA-based microparticles and nanoparticles, the emulsion method is the most adapted from those, listed above and recently the application of the spray drying method has become topical.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery

et al. 2018

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In this study, polymer-based microparticles are used to improve the therapeutic properties of ceftriaxone (CEF) and render them safer. Poly-3-hydroxybutyrate (P3HB) and poly-3-hydroxybutyrate/polyethylene glycol (P3HB-PEG)based microparticles were prepared by two methods: a double emulsification technique and spray-drying. The microparticles were characterized in terms of size and zeta potential, morphology, total drug loading and drug release. The microparticles had spherical shapes with diameters of a size range from 0.74 to 1.55 m (emulsification technique) and from 3.84 to 6.51 m (spray-drying); CEF encapsulation efficiency was around 63% and 49% for these methods respectively. The CEF release from microparticles obtained by spray-drying reached 100% after 150h, while for microparticles obtained by emulsification technique the total release of CEF did not exceed 34% after 312 h. The release profiles could be best explained by Zero order kinetics model, Higuchi and Korsmeyer-Peppas models, as the plots showed high linearity. Antibacterial activity of the microparticles was evaluated against gram-positive and gram-negative bacterial strains. In general, CEF encapsulation in polymeric microparticles preserves the therapeutic efficacy of the CEF and provides its prolonged effect.

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“…Particularly, the availability of nonspherical particle morphologies with narrow size/shape distribution-boomerang, square cross, hexagonal prism, flying saucer, blood cell, w-motif, ellipsoid, peanut, cylinder, spherocylinder, heteronuclear dimer, etc.-expands the approach. [5][6][7][8][9][10][11][12][13] Recently, buckled phases (1B) of anisotropic particles were captured at transition heights between the first and second particulate layers. 16 The mushroom cap-shaped building blocks in the idealized 1B phase self-organize on a rectangular lattice into vertically shifted sublayers, each having a particle orientation preference towards opposite confining walls to achieve the highest packing density (Figures 2 and 3).…”

Section: Introductionmentioning

confidence: 99%

Buckled colloidal crystals with nonspherical bases for two-dimensional slab photonic band gaps

Riley

Fung

Watson

2012

Journal of Applied Physics

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Theoretical modeling of the photonic band gap forming properties is reported for the buckled phase of anisotropic particles. These exist between the first and second particulate layers of confined colloidal suspensions. Inspired by the range of non-spherical mushroom-cap building blocks for self-assembly that have been synthesized using seeded emulsion-polymerization, we explore in particular the band structures as a function of toroid shape parameter. The parameter is adjusted to incrementally transform hemispheres to spheres. Additionally, corrugation heights that systematically modulate the slab photonic crystal unit cell from rectangular monolayer to square bilayer are investigated. Polarization independent gaps in the guided modes are determined for direct and inverted structures that exhibit bifurcation in the particle orientation perpendicular to the slab plane. Gaps in the guided modes are observed between the fourth and fifth, twelfth and thirteenth, as well as higher band locales as the particle morphology and lattice aspect ratio vary.

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Monodisperse polymer particles synthesized by seeded polymerization techniques

Cited by 60 publications

References 62 publications

Facile synthesis of core-shell, multiple compartment anisotropic particles via control of cross-linking and continuous phase separations in one-pot dispersion polymerization

Facile synthesis of core-shell, multiple compartment anisotropic particles via control of cross-linking and continuous phase separations in one-pot dispersion polymerization

Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery

Buckled colloidal crystals with nonspherical bases for two-dimensional slab photonic band gaps

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