Yellow nail syndrome: the nail that grows half as fast grows twice as thick

Moffitt, D. L.; Berker, Dilek

doi:10.1046/j.1365-2230.2000.00563.x

Cited by 29 publications

(14 citation statements)

References 9 publications

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“…A subset of patients with YNS has persistent hypoalbuminemia and increased enteric loss of albumin leading to the speculation that increased microvascular permeability may contribute to its pathogenesis (24). Histologic investigation of the nail bed and matrix has revealed dense, fibrous tissue replacing subungual stroma with ectatic, endothelium‐lined lymphatics (25).…”

Section: Discussionmentioning

confidence: 99%

Yellow Nail Syndrome in Three Siblings: A Randomized Double‐Blind Trial of Topical Vitamin E

Lambert

Dziura

Kauls

et al. 2006

Pediatric Dermatology

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Yellow nail syndrome is an uncommon disorder characterized by dystrophic nails, lymphedema, and respiratory disease. It has rarely been reported in children and this is the first report of congenital yellow nails in siblings. The purpose of this study was to determine whether topical vitamin E applied to the nail plates and periungual skin would affect the growth rate or appearance of the fingernails in patients with congenital yellow nail syndrome. This study was the first trial of a treatment for this entity in children and the largest randomized double blind trial to date. We found that vitamin E solution had no significant effect (p = 0.84) on fingernail growth or the global appearance score (p = 1.0) when compared with placebo. The average growth rates and global assessment scores improved and onycholysis and onychomadesis decreased from baseline with both vitamin E and placebo treatment, although these were not primary end points of the study. Topical vitamin E did not result in a statistically significant improvement when compared with oil alone for the treatment of the nails in our three patients with yellow nail syndrome. However, it is interesting and perhaps clinically useful that both vitamin E and placebo oil improved the condition of the nails.

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Section: Discussionmentioning

confidence: 99%

Yellow Nail Syndrome in Three Siblings: A Randomized Double‐Blind Trial of Topical Vitamin E

Lambert

Dziura

Kauls

et al. 2006

Pediatric Dermatology

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“…In some diseases, this may alter the impression of reduced nail growth – where a nail that is thickened has a low longitudinal growth rate, but is still producing the same mass of nail. This observation has been made in Yellow nail syndrome, where ‘the nail that grows half as fast grows twice as thick’ [143]. Onychomycosis may also be either predisposed to slow growing nails or a factor in their slow growth [144] and directly or indirectly, the antifungal drugs intraconazole and fluconazole may hasten longitudinal growth rate [145].…”

Section: Physiologymentioning

confidence: 99%

Nail biology and nail science

Berker

André

Baran

2007

Intern J of Cosmetic Sci

147

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Synopsis The nail plate is the permanent product of the nail matrix. Its normal appearance and growth depend on the integrity of several components: the surrounding tissues or perionychium and the bony phalanx that are contributing to the nail apparatus or nail unit. The nail is inserted proximally in an invagination practically parallel to the upper surface of the skin and laterally in the lateral nail grooves. This pocket‐like invagination has a roof, the proximal nail fold and a floor, the matrix from which the nail is derived. The germinal matrix forms the bulk of the nail plate. The proximal element forms the superficial third of the nail whereas the distal element provides its inferior two‐thirds. The ventral surface of the proximal nail fold adheres closely to the nail for a short distance and forms a gradually desquamating tissue, the cuticle, made of the stratum corneum of both the dorsal and the ventral side of the proximal nail fold. The cuticle seals and therefore protects the ungual cul‐de‐sac. The nail plate is bordered by the proximal nail fold which is continuous with the similarly structured lateral nail fold on each side. The nail bed extends from the lunula to the hyponychium. It presents with parallel longitudinal rete ridges. This area, by contrast to the matrix has a firm attachment to the nail plate and nail avulsion produces a denudation of the nail bed. Colourless, but translucent, the highly vascular connective tissue containing glomus organs transmits a pink colour through the nail. Among its multiple functions, the nail provides counterpressure to the pulp that is essential to the tactile sensation involving the fingers and to the prevention of the hypertrophy of the distal wall tissue, produced after nail loss of the great toe nail.

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“…Affected nails in this syndrome demonstrate an increase in thickness inversely proportional to the growth rate. 27 The brittle nail syndrome is characterized by dehydration of the nail plate leading to easy fracture and splitting. The nail plates are brittle, frayed at the distal edge, and often demonstrate onychorrhexis and lamellar nail dystrophy (onychoschizia or onychoschisis).…”

Section: Diseases In Which Linear Nail Growth Is Slowedmentioning

confidence: 99%