Modulation of linear nail growth to treat diseases of the nail

Geyer, A; Onumah, Neh; Uyttendaele, Hendrik; Scher, Richard K.

doi:10.1016/j.jaad.2003.07.011

Cited by 56 publications

(35 citation statements)

References 63 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Evidence supports the observation that faster nail growth leads to better treatment outcomes [32,39,40]. For example, a study was done on 199 patients with onychomycosis who were treated with continuous terbinafine vs. intermittent terbinafine who were then recruited for additional observation.…”

Section: Nail Featuresmentioning

confidence: 89%

Prognostic Factors in Onychomycosis Treatment

Lipner

Scher

2014

J Infect Dis Ther

View full text Add to dashboard Cite

Onychomycosis is a common fungal disease of the nail unit with a prevalence of 10% to 12% in the United States. Despite therapeutic innovations in the last few decades, as many as 20-25% of patients do not achieve a complete cure, and 10-53% are reported to relapse after successful treatment. Some of the factors associated with a poor response to onychomycosis have been well studied. They include patient characteristics and morbidities, nail characteristics, and the infecting organism. Therefore, the goal of therapy is to identify these specific prognostic features for each patient and devise an appropriate treatment plan that will allow for the best chance for cure. Scoring systems may be helpful for grading the severity of onychomycosis and predicting the therapeutic outcome.

show abstract

Section: Nail Featuresmentioning

confidence: 89%

Prognostic Factors in Onychomycosis Treatment

Lipner

Scher

2014

J Infect Dis Ther

View full text Add to dashboard Cite

show abstract

“…Generally, it takes 12 to 18 months for a newly formed toenail plate, and 4 to 6 months for a fingernail to replace a diseased nail. 24,25 Several factors may influence the rate of nail growth, including the age of the patient (the rate of linear nail growth decreases by 50% during a normal life span 26 ), concomitant conditions, 24 and certain medications that may cause either an increase or decrease in nail growth. 24,27 Immediately after completion of therapy with one of the newer, long-lasting, systemic antimycotics, the nail usually does not appear to be clear of infection.…”

Section: Timing Of Observationsmentioning

confidence: 99%

Onychomycosis: Diagnosis and definition of cure

Scher

Tavakkol

Sigurgeirsson

et al. 2007

Journal of the American Academy of Dermatology

169

133

View full text Add to dashboard Cite

“…Moreover, several authors did not examine whether the differences that they found were significant or not, and not all the influencing factors were confirmed by later studies. Table 3 summarizes the factors that have been consistently reported by most studies to affect the growth rate of nails [70][71][72][73][74][75][76].…”

Section: Factors Influencing Substance Incorporationmentioning

confidence: 99%

Nail analysis for the detection of drugs of abuse and pharmaceuticals: a review

et al. 2014

View full text Add to dashboard Cite

Nails can stably accumulate substances for long periods of time, thus providing retrospective information regarding drugs of abuse and pharmaceutical use. Nails have several advantages over the conventional matrices, such as blood and urine, including a longer detection window (months to years), non-invasive sample collection, and easy storage and transport. These aspects make nails a very interesting matrix for forensic and clinical toxicology. Because of the low concentrations of drugs of abuse and pharmaceuticals present in nails and the complexity of the keratinized matrix, analytical methods need to be more sensitive, and sample preparation is crucial. This review summarizes the literature regarding the detection and quantification of drugs of abuse and pharmaceuticals in nails, as well as the employed pre-analytical and analytical techniques. Additionally, the applications of nail analysis are reviewed. Finally, an overview of the challenges of nail analysis is provided, and guidelines for future research are proposed.

show abstract

Modulation of linear nail growth to treat diseases of the nail

Cited by 56 publications

References 63 publications

Prognostic Factors in Onychomycosis Treatment

Prognostic Factors in Onychomycosis Treatment

Onychomycosis: Diagnosis and definition of cure

Nail analysis for the detection of drugs of abuse and pharmaceuticals: a review

Contact Info

Product

Resources

About