Year-to-Year Variability of Cholesterol Levels in a Pediatric Practice

Benuck, Irwin

doi:10.1001/archpedi.1995.02170150072013

Cited by 21 publications

(23 citation statements)

References 21 publications

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“…In a study of 646 children 3 to 19 years of age, only 41% of children with a total cholesterol level Ն5.2 mmol/L (Ն200 mg/dL) had a cholesterol level that high 1 year later. 46 The higher the initial cholesterol level, the more likely it was for the repeat value also to be high, and the greater the number of measurements, the smaller the confidence interval around the estimated value. Assessment of 95% confidence limits for predicting a total cholesterol level in 1 year suggests that individuals with total cholesterol levels of Ն5.9 mmol/L (Ն230 mg/dL) from a single measurement or Ն5.6 mmol/L (Ն215 mg/dL) averaged from 2 measurements would have a total cholesterol level of Ն5.2 mmol/L (Ն200 mg/dL).…”

Section: Challenges With These Existing Guidelinesmentioning

confidence: 99%

“…Assessment of 95% confidence limits for predicting a total cholesterol level in 1 year suggests that individuals with total cholesterol levels of Ն5.9 mmol/L (Ն230 mg/dL) from a single measurement or Ն5.6 mmol/L (Ն215 mg/dL) averaged from 2 measurements would have a total cholesterol level of Ն5.2 mmol/L (Ն200 mg/dL). 46 In adults, seasonal variation in total cholesterol levels also has been described, with maximal values obtained during the winter months and minimal values obtained during the summer months. 37 Peak-to-trough changes were 2.6% to 6.3% in men and 1.0% to 4.6% in women.…”

Section: Challenges With These Existing Guidelinesmentioning

confidence: 99%

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Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents

McCrindle¹,

Urbina

Dennison³

et al. 2007

Circulation

362

149

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Abstract-Despite compliance with lifestyle recommendations, some children and adolescents with high-risk hyperlipidemia will require lipid-lowering drug therapy, particularly those with familial hypercholesterolemia. The purpose of this statement is to examine new evidence on the association of lipid abnormalities with early atherosclerosis, discuss challenges with previous guidelines, and highlight results of clinical trials with statin therapy in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia. Recommendations are provided to guide decision-making with regard to patient selection, initiation, monitoring, and maintenance of drug therapy.

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Section: Challenges With These Existing Guidelinesmentioning

confidence: 99%

Section: Challenges With These Existing Guidelinesmentioning

confidence: 99%

Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents

McCrindle¹,

Urbina

Dennison³

et al. 2007

Circulation

362

149

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show abstract

“…Although these percentile curves were derived from crosssectional data, we propose that they will be useful for tracking changes in an adolescent's risk over time and not just for assessing risk at a given time point. This approach assumes that an adolescent's lipoprotein percentile will remain relatively constant as he or she ages (unless a lifestyle change occurs or other treatment is given), a position that is supported by many 4 -7 but not all 23 longitudinal studies that have tracked lipoproteins.…”

Section: Development Of the Adolescent Lipoprotein Classification Systemmentioning

confidence: 99%

Distribution of Lipoproteins by Age and Gender in Adolescents

2006

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Background-The current National Cholesterol Education Program lipoprotein classification system for children and adolescents is recommended for use among 2-to 19-year-olds. This classification system does not take into account gender differences or the natural fluctuations in lipoprotein concentrations that occur with growth and maturation. Methods and Results-Data from the National Health and Nutrition Examination Surveys were used to develop age-and gender-specific thresholds that can be used to denote abnormal levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Each curve was linked to the adult National Cholesterol Education Program Adult Treatment Panel III lipoprotein thresholds using LMS (Lambda-Mu-Sigma) growth curve regression methods. A series of growth curves and tables are presented that can be used to diagnose high-risk lipoprotein levels in the clinical and research settings. For example, in 1-year increments for males starting at age 12 and extending to age 19 years, the high-risk thresholds for total cholesterol were 6. 03, 5.83, 5.70, 5.70, 5.77, 5.88, 6.02, and 6.16 mmol/L. The corresponding high-risk threshold for adults (Ն20 years) is 6.22 mmol/L. Conclusions-The present study is the first attempt at developing age-and gender-specific lipoprotein threshold concentrations for adolescents. This new classification system should provide a more accurate diagnosis of high-risk lipoprotein levels and associated cardiovascular risks in adolescents.

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“…O risco de hipercolesterolemia tem sido associado a vários fatores, como idade, sexo, pressão arterial, índice ponderal ou índice de massa corporal, tabagismo, história familiar de doença cardiovascular, uso de contraceptivo oral e dieta (BADRUDDIN et al, 1994;BENUCK et al, 1995;MYERS et al, 1995).…”

Section: Introductionunclassified

Perfil lipídico de dietas e sua relação com os níveis de colesterolemia em escolares de uma escola pública de Campinas, São Paulo, (Brasil)

Moura¹,

Sonati²

1998

Rev. Nutr.

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(1) Auxílio Parcial do Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq na forma de bolsas de apoio técnico, iniciação científica, aperfeiçoamento e pesquisa. LIPID PROFILE OF DIETS AND THE CORRELATION WITH SERUM CHOLESTEROL IN LIPID PROFILE OF DIETS AND THE CORRELATION WITH SERUM CHOLESTEROL IN LIPID PROFILE OF DIETS AND THE CORRELATION WITH SERUM CHOLESTEROL IN LIPID PROFILE OF DIETS AND THE CORRELATION WITH SERUM CHOLESTEROL IN LIPID PROFILE OF DIETS AND THE CORRELATION WITH SERUM CHOLESTEROL IN SCHOOLCHILDREN FROM PUBLIC SCHOOL IN CAMPINAS, SÃO PAULO (BRAZIL) SCHOOLCHILDREN FROM PUBLIC SCHOOL IN CAMPINAS, SÃO PAULO (BRAZIL) SCHOOLCHILDREN FROM PUBLIC SCHOOL IN CAMPINAS, SÃO PAULO (BRAZIL) SCHOOLCHILDREN FROM PUBLIC SCHOOL IN CAMPINAS, SÃO PAULO (BRAZIL) SCHOOLCHILDREN FROM PUBLIC SCHOOL IN CAMPINAS, SÃO PAULO (BRAZIL)

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Year-to-Year Variability of Cholesterol Levels in a Pediatric Practice

Cited by 21 publications

References 21 publications

Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents

Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents

Distribution of Lipoproteins by Age and Gender in Adolescents

Perfil lipídico de dietas e sua relação com os níveis de colesterolemia em escolares de uma escola pública de Campinas, São Paulo, (Brasil)

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