2019
DOI: 10.1016/j.cub.2018.11.029
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Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders

Abstract: Highlights d We sequenced 20 Native American Y chromosomes chosen for their genetic diversity d A Beringian Standstill of <4,600 years led to both Siberian and American Y-lineages d Y-lineage split times rule out occupation of the Americas before 19,500 years ago d Present-day male population structure in South America arose before 12,000 years ago

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Cited by 103 publications
(203 citation statements)
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References 62 publications
(100 reference statements)
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“…, mirroring observations of rapid diversification of mitochondrial and Y-chromosome lineages at this time(24,25) but 215 not previously observed using autosomal data. While this inference is sensitive to SMC++ parameter settings and likely counteracted by very recent bottlenecks in the Native American groups, other populations do not display similar histories under these parameter settings.…”
supporting
confidence: 85%
“…, mirroring observations of rapid diversification of mitochondrial and Y-chromosome lineages at this time(24,25) but 215 not previously observed using autosomal data. While this inference is sensitive to SMC++ parameter settings and likely counteracted by very recent bottlenecks in the Native American groups, other populations do not display similar histories under these parameter settings.…”
supporting
confidence: 85%
“…For example, the basic haplogroup C defined by the SNP M130 is widespread in Central and East Asia, Australia and the Americas. Mutations further down the C branch arose later and are, therefore, restricted to lately occupied parts of the New World, for example, the derived American founder mutation C3 defined by SNP MPB373 occurs only in native groups living in the Northwest of South America (Pinotti et al, ). In Europe, collaborative exercises with blind samples are annually organized since 2017 in order to validate ancestry prediction methods for forensic use.…”
Section: Ancestry Inference Using the Y Chromosomementioning
confidence: 99%
“…The red line depicts concordance between observed and estimated haplotype frequencies; the green line marks the threshold of the DL frequency estimation for very rare haplotypes in this MP which is based on the distribution of singletons frequency estimates. To the left, the density distribution of the singleton estimates is plotted (modified from native groups living in the Northwest of South America (Pinotti et al, 2018). In Europe, collaborative exercises with blind samples are annually organized since 2017 in order to validate ancestry prediction methods for forensic use.…”
Section: Ancestry Inference Using the Y Chromosomementioning
confidence: 99%
“…Within M3, two major lineages have been established as founding of Native Americans, Q‐Y4308 and Q‐M848 (Pinotti et al, ). Q‐Y4308 has been found in low frequencies, but with a wide range of distribution, observed from Siberia to South America (Grugni et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…Q‐Y4308 has been found in low frequencies, but with a wide range of distribution, observed from Siberia to South America (Grugni et al, ). On the other hand, Q‐M848 is widely distributed, representing the most representative founding lineage Q‐M3 (Pinotti et al, ). Within M848, the International Society of Genetic Genealogy (ISOGG) has recognized several sublineages, among which are Q1b1a1a1a (M19), Q1b1a1a1b (M194), Q1b1a1a1c (M199), Q1b1a1a1d (SA01), Q1b1a1a1e (CTS11357), Q1b1a1a1f (Z35840) and Q1b1a1a1g–Q1b1a1a1w (ISOGG, ).…”
Section: Introductionmentioning
confidence: 99%