2019
DOI: 10.1002/wfs2.1336
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Y‐chromosome short tandem repeats in forensics—Sexing, profiling, and matching male DNA

Abstract: The analysis of short tandem repeat (STR) markers located on the Y chromosome is an established method in forensic casework analysis. Usually this method is applied in cases of male‐on‐female sexual assault, in which the victim's DNA is in great excess and masked the male contribution. Y‐STR analysis is able to detect the presence of minuscule amounts of male DNA of one or multiple donors and resulting genetic profiles can be compared to known reference samples. The expert has to determine whether the Y‐STR re… Show more

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Cited by 42 publications
(32 citation statements)
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“…However, Y-STR haplotypes are shared across paternal relatives and cannot be used to directly identify its source. Without autosomal data, other non-DNA evidence that could provide leads in supporting or negating the contribution of a paternal relative should be considered [ 26 , 27 ]. In all other scenarios when female to male ratio is less than 10:1, using both autosomal and Y-STR profiles will maximize DNA information obtained from a sample.…”
Section: An Integrated System For Dna Testing In Sexual Assault Casesmentioning
confidence: 99%
“…However, Y-STR haplotypes are shared across paternal relatives and cannot be used to directly identify its source. Without autosomal data, other non-DNA evidence that could provide leads in supporting or negating the contribution of a paternal relative should be considered [ 26 , 27 ]. In all other scenarios when female to male ratio is less than 10:1, using both autosomal and Y-STR profiles will maximize DNA information obtained from a sample.…”
Section: An Integrated System For Dna Testing In Sexual Assault Casesmentioning
confidence: 99%
“…However, the relatively small number of 13 previously identified RM Y-STRs provides limitations for male relative differentiation, particularly regarding closely related men, which limits applications in forensic genetics and genetic genealogy (Roewer, 2019). Empirical studies based on hundreds of male relative pairs showed that these 13 RM Y-STRs allow separation of males related by one, two, three, and four meioses with 27%, 46%, 54%, and 62%, respectively (Adnan et al, 2016), which demonstrates room for improvement.…”
Section: Introductionmentioning
confidence: 99%
“…Because of variation in STRs lenght and high meutation rate, it promoted the genetic polymorphism of STRs markers and therefore useful in human identity testing. The investigation of Y-STRs is a useful reliable marker for personal identity in forensic genetic cases including paternity testing in paternal lineage, historical cases, special cases of the missing person or disaster victim identification involving men, ancestor study, as well as sexual assault with mixed DNA profile between male and female DNA 2,3 . Moreover, Y-STRs analysis can be crucial for sex confirmation in the case of amelogenin dropout 4 .…”
Section: Introductionmentioning
confidence: 99%