XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) Single Nucleotide Polymorphisms in Cervical Cancer Risk

Abstract

Human Papillomavirus (HPV) is the main cause of cervical cancer and its precursor lesions. Transformation may be induced by several mechanisms, including oncogene activation and genome instability. Individual differences in DNA damage recognition and repair have been hypothesized to influence cervical cancer risk. The aim of this study was to evaluate whether the double strand break gene polymorphisms XRCC2 R188H G>A (rs3218536), XRCC3 T241M C>T (rs861539) and R243H G>A (rs77381814) are associated to cervical cancer in Argentine women. A case control study consisting of 322 samples (205 cases and 117 controls) was carried out. HPV DNA detection was performed by PCR and genotyping of positive samples by EIA (enzyme immunoassay). XRCC2 and 3 polymorphisms were determined by pyrosequencing. The HPV-adjusted odds ratio (OR) of XRCC2 188 GG/AG genotypes was OR = 2.4 (CI = 1.1-4.9, p = 0.02) for cervical cancer. In contrast, there was no increased risk for cervical cancer with XRCC3 241 TT/CC genotypes (OR = 0.48; CI = 0.2-1; p = 0.1) or XRCC3 241 CT/CC (OR = 0.87; CI = 0.52-1.4; p = 0.6). Regarding XRCC3 R243H, the G allele was almost fixed in the population studied. In conclusion, although the sample size was modest, the present data indicate a statistical association between cervical cancer and XRCC2 R188H polymorphism. Future studies are needed to confirm these findings.

Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey

“…On the other hand, determined that there were polymorphic regions that were more frequently associated with melanoma skin cancer than cancer occurring in head, neck, bladder, and breast cancer. Th erefore, the eff ect of the XRCC3 gene varies in diff erent cancer types [31][32][33][34][35]. A recent study conducted in Poland focused on same genomic regions and cancer type, and has shown that the regions of interest are associated with cancer [19,20].…”

Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

“…Manual search of references cited in 1 additional article, but it was excluded for lack of data about XRCC3 Thr241Met gene polymorphism of cervical cancer (Wang et al, 2009). Finally, a total of 5 relevant studies including 4 English articles (He et al, 2008;Settheetham-Ishida et al, 2011;Djansugurova et al, 2013;Perez et al, 2013) and 1 Chinese paper (Xiao et al, 2010) met the inclusion criteria for the meta-analysis (including a total of 806 cervical cancer cases and 850 controls). There were 3 studies of Asians (He et al, 2008;Xiao et al, 2009;Settheetham-Ishida et al, 2011) and 2 studies of Caucasians (Djansugurova et al, 2013;Perez Table 1.…”

Assessment of role of genetic polymorphisms in XRCC1, XRCC2 and XRCC3 genes in cervical cancer susceptibility from a rural population: a hospital based case-control study from Maharashtra, India

“…18,19 Some reports stated that XRCC2 (Arg188His) polymorphisms may be involved in repair of HPV related DNA damage in cervical cancer. 20 But the results were debatable where few observations were not consistent in terms to show association between polymorphisms of XRCC1 Arg194Trp and development of cervical cancer, while the influence of the Arg280His polymorphisms acted as protective factor for squamous cervical carcinoma and Arg399Gln polymorphism increased cervical carcinogenesis among women whose age at first delivery was 20 years. 21 Also, few studies form India have been carried out to investigate association of XRCC1 gene with CC risk especially from Northern India and Southern India but they did not lead to a broad strapping conclusions.…”