Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey

Gok, Ilhami; Baday, Meryem; Cetinkunar, Suleyman; Kılıç, Kemal; Bilgin, Bülent Çağlar

doi:10.17305/bjbms.2014.4.7

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…For fifth selected polymorphism of XRCC2 gene, rs3218536, frequency of risk allele was observed significantly higher in patients compared to controls. Similar results have earlier been reported where significant association was observed between XRCC2 polymorphism rs3218536 with laryngeal and pharyngeal cancer risk 40 , thyroid cancer risk 41 , ovarian cancer 42 , gastric cancer risk 43 , oral cancer 44 and head and neck cancer 45 . Nevertheless, some of the studies have also reported that there is no significant association between XRCC2 - rs3218536 polymorphism and thyroid cancer 46 , 47 .…”

Section: Discussionsupporting

confidence: 91%

Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer

Saeed

Mahjabeen

Sarwar

et al. 2017

Sci Rep

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We aimed to investigate the effect of hotspot variations of XRCC2 gene on the risk of head and neck cancer (HNC) in 400 patients and 400 controls. Five polymorphisms of XRCC2 gene G4234C (rs3218384), G4088T (rs3218373), G3063A (rs2040639), R188H (rs3218536) and rs7802034 were analyzed using Allele- specific polymerase chain reaction (ARMS-PCR) followed by sequence analysis. For rs3218373, the GG genotype indicated a statistically significant 3-fold increased risk of HNC (P < 0.001) after multivariate adjustment. For rs7802034, the GG genotype suggested statistically significant 2-fold increased risk of HNC (P < 0.001). For SNP of rs3218536, the AA genotype indicated a significant 3-fold increased risk of HNC (P < 0.001). Additionally, haplotype analysis revealed that TACAG, TGGAG, TACGG and TAGGA haplotypes of XRCC2 polymorphisms are associated with HNC risk. Two SNPs in XRCC2 (rs2040639 and rs3218384) were found increased in strong linkage disequilibrium. Furthermore, joint effect model showed 20 fold (OR = 19.89; 95% CI = 2.65–149.36, P = 0.003) increased HNC risk in patients carrying four homozygous risk alleles of selected polymorphisms. These results show that allele distributions and genotypes of XRCC2 SNPs are significantly associated with increased HNC risk and could be a genetic adjuster for the said disease.

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Section: Discussionsupporting

confidence: 91%

Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer

Saeed

Mahjabeen

Sarwar

et al. 2017

Sci Rep

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“…Lower levels of XRCC2 expression have been found in breast cancer tissues [ 32 ], while higher levels of XRCC2 expression have been detected in several other cancers [ 16 , 23 , 33 ]. It is hypothesized that XRCC2 expression is involved in either the initiation or progression of tumorigenesis [ 23 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy

et al. 2015

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XRCC2 has been shown to increase the radioresistance of some cancers. Here, XRCC2 expression was investigated as a predictor of preoperative radiotherapy (PRT) treatment response in locally advanced rectal cancer (LARC). XRCC2 was found to be overexpressed in rectal cancer tissues resected from patients who underwent surgery without PRT. In addition, overall survival for LARC patients was improved in XRCC2-negative patients compared with XRCC2-positive patients after treatment with PRT (P < 0.001). XRCC2 expression was also associated with an increase in LARC radioresistance. Conversely, XRCC2-deficient cancer cells were more sensitive to irradiation in vitro, and a higher proportion of these cells underwent cell death induced by G2/M phase arrest and apoptosis. When XRCC2 was knocked down, the repair of DNA double-strand breaks caused by irradiation was impaired. Therefore, XRCC2 may increases LARC radioresistance by repairing DNA double-strand breaks and preventing cancer cell apoptosis. Moreover, the present data suggest that XRCC2 is a useful predictive biomarker of PRT treatment response in LARC patients. Thus, inhibition of XRCC2 expression or activity represents a potential therapeutic strategy for improving PRT response in LARC patients.

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“…This polymorphism may be also associated with increased risk of gastric and pharyngeal cancers [14,15].…”

Section: Discussionmentioning

confidence: 99%

Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 ( XRCC2 ) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population

Romanowicz¹,

Bryś²,

Forma³

et al. 2016

J Gynecol Res Obstet

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Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey

Cited by 11 publications

References 31 publications

Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer

Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer

XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy

Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 ( XRCC2 ) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population

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