Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 ( XRCC2 ) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population

Romanowicz, Hanna; Bryś, Magdalena; Forma, Ewa; Smolarz, Beata

doi:10.17352/jgro.000018

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Another case study on Polish population (Warsaw) also said that the feasible character of XRCC2 gene polymorphism is responsible for neoplastic diseases. Therefore, XRCC2 polymorphisms may take part dominant role in colorectal cancer tumorigenesis, conferring susceptibility to rectal tumors in Polish population (Romanowicz et al, 2016). Similar relationship is also observed when studied on English population (Cartwright et al, 1998).…”

Section: Discussionsupporting

confidence: 70%

Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Hridy

Shabnaz

Asaduzzaman

et al. 2020

Asian Pac J Cancer Prev

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Objectives: In case of Bangladeshi population, no report is observed till now showing the genetic variations of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism having association with colorectal cancer risk. For this reason the aim of this study is to ascertain their interrelation with colorectal cancer occurrence in Bangladeshi population. Materials and Methods: A case control study was conducted where 200 colorectal cancer patients and 200 healthy volunteers were figured for this research using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Here, in case of RAD51 (rs1801320), G/C heterozygous genotype was found significant (p=0.037; OR=1.64; 95% CI=1.03 to 2.6). On the other hand, G/G genotype was not found statistically significant (p=0.423; OR=1.61; 95% CI=0.49 to 5.22) and significance was observed for GC+GG (p=0.030; OR=1.63; 95% CI=1.05 to 2.55). In case of XRCC2 (rs3218536), C/T heterozygous genotype was remarked statistically significant (p=0.033; OR=1.60; 95% CI=1.04 to 2.46). The T/T genotype was not recorded statistically significant (p=0.237; OR=1.65; 95% CI=0.72 to 3.76) but significance found for CT+TT (p=0.027; OR=1.61; 95% CI=1.05 to 2.45). Moreover, it is found that the risk factor of developing CRC is observed in G/C, C/T heterozygote and GC+GG, CT+TT (heterozygote+ mutant) in RAD51 (rs1801320) and XRCC2 (rs3218536) respectively although no significance is observed in case of G/G and T/T mutant. Conclusions: So, the association of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism with colorectal cancer risk is observed in Bangladeshi population.

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Section: Discussionsupporting

confidence: 70%

Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Hridy

Shabnaz

Asaduzzaman

et al. 2020

Asian Pac J Cancer Prev

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“…Theoretically, genetic variants in XRCC2 gene can change the regular function of this gene, disturb the DNA repair and subsequently increase the cancer risk 54 . Nevertheless, some of the previous studies have reported that the variant alleles of this polymorphism can increase resistance to DNA damage induced by cisplatin 50 , 55 which enlightens protective function of this polymorphism under certain conditions.…”

Section: Discussionmentioning

confidence: 94%

Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer

Saeed

Mahjabeen

Sarwar

et al. 2017

Sci Rep

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We aimed to investigate the effect of hotspot variations of XRCC2 gene on the risk of head and neck cancer (HNC) in 400 patients and 400 controls. Five polymorphisms of XRCC2 gene G4234C (rs3218384), G4088T (rs3218373), G3063A (rs2040639), R188H (rs3218536) and rs7802034 were analyzed using Allele- specific polymerase chain reaction (ARMS-PCR) followed by sequence analysis. For rs3218373, the GG genotype indicated a statistically significant 3-fold increased risk of HNC (P < 0.001) after multivariate adjustment. For rs7802034, the GG genotype suggested statistically significant 2-fold increased risk of HNC (P < 0.001). For SNP of rs3218536, the AA genotype indicated a significant 3-fold increased risk of HNC (P < 0.001). Additionally, haplotype analysis revealed that TACAG, TGGAG, TACGG and TAGGA haplotypes of XRCC2 polymorphisms are associated with HNC risk. Two SNPs in XRCC2 (rs2040639 and rs3218384) were found increased in strong linkage disequilibrium. Furthermore, joint effect model showed 20 fold (OR = 19.89; 95% CI = 2.65–149.36, P = 0.003) increased HNC risk in patients carrying four homozygous risk alleles of selected polymorphisms. These results show that allele distributions and genotypes of XRCC2 SNPs are significantly associated with increased HNC risk and could be a genetic adjuster for the said disease.

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A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh

Babu

Islam

2022

Mol Biol Rep

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Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 ( XRCC2 ) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population

Cited by 3 publications

References 18 publications

Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Haplotype analysis of XRCC2 gene polymorphisms and association with increased risk of head and neck cancer

A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh

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