Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

Qin, Lingyan; Xu, Chen; Li, Ping; Zheng, Yang; Mo, Wuning

doi:10.7314/apjcp.2013.14.11.6703

Cited by 14 publications

(16 citation statements)

References 18 publications

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“…Based on a similar hypothesis of influencing radiotoxicity, the association of XRCC3 polymorphisms with cancer risk has also been extensively evaluated. Evidence from meta-analysis supports a positive association between the XRCC3 p.Thr241Met polymorphism and the risk of bladder cancer [ 56 – 57 ], breast cancer [ 58 – 59 ], cervical cancer [ 60 – 61 ] and hepatocellular carcinoma [ 62 – 63 ]. However, in glioma [ 64 – 65 ], NSCLC [ 66 – 67 ], colorectal cancer [ 68 – 69 ] and gastric cancer [ 70 – 71 ] patients, the associations were not significant.…”

Section: Discussionmentioning

confidence: 99%

Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis

et al. 2015

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The X-ray repair cross-complementing group 3 (XRCC3) protein plays an important role in the repair of DNA double-strand breaks. The relationship between XRCC3 polymorphisms and the risk of radiation-induced adverse effects on normal tissue remains inconclusive. Thus, we performed a meta-analysis to elucidate the association between XRCC3 polymorphisms and radiation-induced adverse effects on normal tissue. All eligible studies up to December 2014 were identified through a search of the PubMed, Embase and Web of Science databases. Seventeen studies involving 656 cases and 2193 controls were ultimately included in this meta-analysis. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the association between XRCC3 polymorphisms and the risk of radiation-induced normal tissue adverse effects. We found that the XRCC3 p.Thr241Met (rs861539) polymorphism was significantly associated with early adverse effects induced by radiotherapy (OR = 1.99, 95%CI: 1.31–3.01, P = 0.001). A positive association lacking statistical significance with late adverse effects was also identified (OR = 1.28, 95%CI: 0.97–1.68, P = 0.08). In addition, the rs861539 polymorphism was significantly correlated with a higher risk of adverse effects induced by head and neck area irradiation (OR = 2.41, 95%CI: 1.49–3.89, p = 0.0003) and breast irradiation (OR = 1.41, 95%CI: 1.02–1.95, p = 0.04), whereas the correlation was not significant for lung irradiation or pelvic irradiation. Furthermore, XRCC3 rs1799794 polymorphism may have a protective effect against late adverse effects induced by radiotherapy (OR = 0.47, 95%CI: 0.26–0.86, P = 0.01). Well-designed large-scale clinical studies are required to further validate our results.

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Section: Discussionmentioning

confidence: 99%

Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis

et al. 2015

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“…Ling-Yan Qin et al showed that the XRCC3 Thr241Met polymorphism might not act as a cervical cancer risk factor. However, in subgroup analysis, a significant association was found in Asians under all genetic models (Qin et al, 2013). The association should be studied with a larger, stratified population.…”

mentioning

confidence: 87%

Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

Mao

Qian²,

Wu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…XRCC3 sequence variations may affect the function of the encoded protein and consequently alter its DNA repair capacity (Matullo et al, 2001). Moreover, recent meta-analyses have suggested that the T241M polymorphism is associated with an increased risk of lung and cervical cancers (Qiu et al, 2013;Qin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis

Rb¹,

Ys²,

Ar³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3) T241M polymorphism and hepatocellular carcinoma (HCC) risk. However, the results of such investigations have proved inconsistent. Therefore, we performed a meta-analysis of the association between this polymorphism and HCC risk in the Chinese population. Published literature from PubMed and China National Knowledge Infrastructure databases was retrieved, and a total of 5 case-control studies consisting of 2967 patients and 3874 controls were included in this meta-analysis, which revealed a significant association between the XRCC3 T241M polymorphism and HCC risk (TT vs MM: OR = 6.54, 95%CI = 2.14-19.99; TT vs MT: OR = 4.72, 95%CI = 2.26-9.86; dominant model: OR = 0.38, 95%CI = 0.26-0.57; recessive model: OR = 1.27, 95%CI = 0.99-1.62). In a subgroup analysis by sample size (number of subjects > 1000), similar results were obtained. Thus, XRCC3 T241M polymorphism may constitute a risk factor for HCC in the Chinese population.

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Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

Cited by 14 publications

References 18 publications

Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis

Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis

Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

DNA repair gene XRCC3 T241M polymorphism and susceptibility to hepatocellular carcinoma in a Chinese population: a meta-analysis

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