XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain–gut axis and production of neuropeptides

Liu, Jing; Li, Feng; Tang, Xudong; Ma, Jie; Ma, Xin; Ge, Dongyu; Genmao, Li; Wang, Yong

doi:10.1186/s12906-015-0913-z

Cited by 23 publications

(14 citation statements)

References 34 publications

(38 reference statements)

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“…Gastric compliance and sensitivity were evaluated by using barostat and electrophysiological recorder as reported previously [ 14 , 15 ]. Briefly, the rats were temporarily anesthetized by isoflurane.…”

Section: Methodsmentioning

confidence: 99%

Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia

Chang

Zhao

Wang

et al. 2017

BMC Complement Altern Med

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BackgroundRecent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to the pathogeneses of functional dyspepsia (FD). Thus, restoring normal barrier integrity becomes a potential therapeutic strategy in the treatment of FD. Sini-San (SNS) is a traditional Chinese prescription that exhibits therapeutic effects in FD, but the underlying mechanisms remain not well understood.MethodsFD rats were established by tail clamping method and the therapeutic effect of SNS was evaluated by measuring the visceral sensitivity and gastric compliance. Transepithelial electrical resistance (TEER) that reveals epithelial barrier integrity was measured by Ussing chamber. The expression of tight junction (TJ) proteins, occludin and claudin-1, in the duodenum was determined by Western blot and immunofluorescence. The amount of tumor necrosis factor alpha (TNF-α) and interferon gamma (INF-γ) in duodenal mucosa was detected by enzyme-linked immune sorbent assay (ELISA). The mRNA level of transient receptor potential vanilloid type 1 (TRPV1) was measured by quantitative real time-polymerase chain reaction (qPCR).ResultsSNS could improve gastric compliance and attenuate visceral hypersensitivity (VH) in FD rats. TEER was decreased in FD rats, but treatment with SNS restored normal level of TEER and the expression of occludin and claudin-1 in FD rats. In addition, SNS administration ameliorated FD-associated increase in the production of TNF-α, IFN-γ and the expression of TRPV1.ConclusionsThe therapeutic effect of SNS on FD is at least partially through improvement of TJ integrity and attenuation of FD-associated low-grade inflammation in the duodenum. Our findings highlight the molecular basis of SNS-based treatment of FD in human patients.Electronic supplementary materialThe online version of this article (10.1186/s12906-017-1938-2) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia

Chang

Zhao

Wang

et al. 2017

BMC Complement Altern Med

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“…Calcitonin gene-related peptide (CGRP) is involved in the sensitization of the afferent neuronal pathways in FD 37 . Vasoactive intestinal polypeptide (VIP) is involved in many physiological intestinal functions, such as motility regulation, secretory activity, peristaltic reflex inhibition in the circular smooth muscle layer and sphincter relaxation 38,39 . Additionally, enhanced CGRP and VIP could form a basis for the appearance of FD symptoms 40 .…”

Section: Discussionmentioning

confidence: 99%

Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia

Wei

Man

Guo

et al. 2019

Sci Rep

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Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization in the clinic, as well as corresponding mechanism, is ambiguous, thus hindering their widespread use. To meet this requirement, a precise and systematic approach based on a restriction of special disease-related molecules and the following network pharmacology analysis was developed and applied to a multicomponent conventional drug, XiaoErFuPi (XEFP) granules. Experimental verification of the results indicates that this approach can facilitate the prediction, and the precise and systematic efficacy of XEFP could be easily revealed, which shows that XEFP has an advantage over the positive control drug on lactate, gastrin, interleukin 4 and calcitonin gene-related peptide. Moreover, by the proteomics analysis, its superposition of multi-target effects was revealed and a new candidate target for the treatment of FD, striatin, was obtained and verified. This study provides a practicable precise approach for the investigation of the efficacy of multicomponent drugs against FD and offers a promising alternative for the systematical management of FD.

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“…Besides, animal experiment proved that JLT medicine can enhance rats’ gastric emptying by increasing the content of motilin, gastrin, ghrelin, 5-hydroxytryptamine, decreasing the content of calcitonin gene related peptide and up-regulating the expressions of 5-HT 4 R (5-hydroxytryptamine 4 receptor) mRNA and 5-HT 4 R protein [55] . There was also experiment showed that JLT medicine can raise the levels of ghrelin, cholecystokinin, and vasoactive intestinal polypeptide in rats to alleviate the symptoms of FD [56] . Study of Xiaona Wang showed that JLT medicine can increase the expression level of CaMKII (Ca [2+] /calmodulin-dependent kinase II) to promote gastric motility in rats [57] .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Jianpi Liqi therapy for functional dyspepsia

Dai

et al. 2019

Medicine

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Background:We performed this meta-analysis to assess the efficacy and safety of Jianpi Liqi therapy (JLT), a traditional Chinese medicine therapy, in treating functional dyspepsia (FD).Methods:We systematically searched 13 databases from their inception to 15th, May 2019. Eligible studies were randomized controlled trials (RCTs) that compared JLT medicine with conventional pharmacotherapy (CP) in treating patients with FD. Cochrane Collaboration tool, Review Manager 5.3 and STATA 11.0, GRADE profiler 3.6 were used for evaluating risk of bias, analyzing, and assessing quality of evidence respectively.Results:After exclusions, 15 RCTs including a total of 1451 participants were included for analysis. We found evidence that JLT had better efficacy than CP (domperidone, omeprazole, esomeprazole, mosapride, lansoprazole, compound digestive enzymes, lactasin tablets) for FD (OR 0.34; 95% CI 0.26, 0.45; P < .00001). Moreover, JLT had more improvement on symptoms including abdominal pain, abdominal distention, early satiety, belching, poor appetite, and fatigue compared with CP. In addition, serious adverse events were not observed in treatment courses.Conclusion:This meta-analysis suggested that JLT appears to have better efficacy in treating FD compared with CP. It may be an effective and safe therapy option for patients with FD. Though, more large-sample and strictly designed RCTs are needed to confirm our findings.PROSPERO registration number: CRD42019133241.

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XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain–gut axis and production of neuropeptides

Cited by 23 publications

References 34 publications

Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia

Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia

Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia

Efficacy of Jianpi Liqi therapy for functional dyspepsia

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