Xenon anesthesia and beyond: pros and cons

Jin, Zhaosheng; Piazza, Ornella; Ma, Ding; Scarpati, Giuliana; Robertis, Edoardo De

doi:10.23736/s0375-9393.18.12909-9

Cited by 18 publications

(10 citation statements)

References 56 publications

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“…7 in January, Ma published an exhaustive Pros-cons article on Xenon focused not only on pharmacodynamic and pharmacokinetic properties but also on collateral effects, such as the cytoprotective one. 8 Pros included rapid induction and fast recovery a worldwide consensus on the subject would be highly desirable.…”

Section: General Anesthesiamentioning

confidence: 99%

A year in review in Minerva Anestesiologica 2020. Anesthesia, analgesia, and perioperative medicine

Cavaliere¹,

Allegri²,

Apan³

et al. 2021

Minerva Anestesiol

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Section: General Anesthesiamentioning

confidence: 99%

A year in review in Minerva Anestesiologica 2020. Anesthesia, analgesia, and perioperative medicine

Cavaliere¹,

Allegri²,

Apan³

et al. 2021

Minerva Anestesiol

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“…Autophagy and apoptosis pathways, the PKC system, the ERK 1/2 signaling pathway, the inflammatory response, the NO system, mitochondrial dysfunction, body inflammatory response, intracellular calcium overload, oxidative stress and other pathways have been shown to be involved in these protective effects [29][30][31][32]. Therefore, to understanding the mechanisms of anesthetics can promote the progress of related research [33][34][35][36].…”

Section: Organ Function Protection By Anesthetics and Anesthesiamentioning

confidence: 99%

Precision Organ Function Protection for Enhanced Recovery after Surgery

Lu¹,

Xiu-Xiu²,

Wang³

et al. 2019

Transl Perioper & Pain Med

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The concept of enhanced recovery after surgery (ERAS) has gained gratifying achievements in clinical practice, but there are still many disputes and incompatibilities in its application. The reasons for this phenomenon are multifaceted, is evident at multilevels and needs further exploration and improvement.By combining previous studies and our clinical experience, we propose an enhanced concept of ERAS, i.e., precision organ function protection (POFP) for ERAS to promote lasting rehabilitation of patients after surgery. We prefer to use "important organ function outcomes" (IOFOs) as the clinical target of ERAS. Perioperative optimal organ function preservation by using a series of techniques can help patients recover quickly and return to baseline function as soon as possible. This concept has greatly expanded the connotation of the traditional ERAS, whose core idea was reducing stress, providing analgesia and humane care.

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“…A distinctive feature of xenon compared to the other noble gases is its lipophilicity and ability to induce an anesthetic effect at a relatively low pressure (0.4-0.8 atm) [2,3]. Xenon has been employed in clinical medicine for inhalation anesthesia [4]. Several studies have demonstrated cytoprotective effects from xenon in various CNS injuries (trauma; ischemia, including severe neonatal asphyxia; subarachnoid hemorrhage) [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Xenon Treatment on Gene Expression in Brain Tissue after Traumatic Brain Injury in Rats

et al. 2021

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The overactivation of inflammatory pathways and/or a deficiency of neuroplasticity may result in the delayed recovery of neural function in traumatic brain injury (TBI). A promising approach to protecting the brain tissue in TBI is xenon (Xe) treatment. However, xenon’s mechanisms of action remain poorly clarified. In this study, the early-onset expression of 91 target genes was investigated in the damaged and in the contralateral brain areas (sensorimotor cortex region) 6 and 24 h after injury in a TBI rat model. The expression of genes involved in inflammation, oxidation, antioxidation, neurogenesis and neuroplasticity, apoptosis, DNA repair, autophagy, and mitophagy was assessed. The animals inhaled a gas mixture containing xenon and oxygen (ϕXe = 70%; ϕO2 25–30% 60 min) 15–30 min after TBI. The data showed that, in the contralateral area, xenon treatment induced the expression of stress genes (Irf1, Hmox1, S100A8, and S100A9). In the damaged area, a trend towards lower expression of the inflammatory gene Irf1 was observed. Thus, our results suggest that xenon exerts a mild stressor effect in healthy brain tissue and has a tendency to decrease the inflammation following damage, which might contribute to reducing the damage and activating the early compensatory processes in the brain post-TBI.

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Xenon anesthesia and beyond: pros and cons

Cited by 18 publications

References 56 publications

A year in review in Minerva Anestesiologica 2020. Anesthesia, analgesia, and perioperative medicine

A year in review in Minerva Anestesiologica 2020. Anesthesia, analgesia, and perioperative medicine

Precision Organ Function Protection for Enhanced Recovery after Surgery

Effect of Xenon Treatment on Gene Expression in Brain Tissue after Traumatic Brain Injury in Rats

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