Xenogenic Bone Matrix Extracts Induce Osteoblastic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

El-Sabban, Marwan; El-Khoury, Hilda; Hamdan-Khalil, Rima; Sindet‐Pedersen, Steen; Bazarbachi, Ali

doi:10.2217/17460751.2.4.383

Cited by 35 publications

(26 citation statements)

References 41 publications

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“…By culturing human mesenchymal stem cells over-expressing human telomerase reverse transcriptase (hMSC-TERT) in plates coated with BPE at different concentrations, Woo et al [61] demonstrated that BPE could increase the proliferation of undifferentiated hMSC-TERT cells and accelerate osteoblastic differentiation of hMSC-TERT cells with a limited effect on proliferation. It was also observed by El-Sabban et al [66] that BPE could induce osteoblastic differentiation of in vitro expanded BMSCs.…”

Section: Stem Cell Interactionsupporting

confidence: 53%

An overview on bone protein extract as the new generation of demineralized bone matrix

Zhou

Zou

et al. 2012

Sci. China Life Sci.

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Bone protein extract is regarded as the new generation of demineralized bone matrix. The aim of this paper is to describe and characterize the properties of demineralized bone matrix and its new generation product in addition to its application in animal and human studies. Bone protein extract has features of osteoconductivity, osteoinductivity and osteogenicity, which originate from its unique and precise processing. It has exhibited powerful bone formation capacity both in animal experiments and in clinical trials by providing an optimal microenvironment for osteogenesis. Furthermore, not only does it have excellent biocompatibility, it also has good compatibility with other implant materials, helping it bridge the host and implanted materials. Bone protein extract could be a promising alternative for demineralized bone matrix as a bone graft substitute. bone protein extract, demineralized bone matrix, autologous bone graft, osteogenesis

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Section: Stem Cell Interactionsupporting

confidence: 53%

An overview on bone protein extract as the new generation of demineralized bone matrix

Zhou

Zou

et al. 2012

Sci. China Life Sci.

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“…This has raised the question of whether adjuvant therapies with BMPs mainly raise the overall bone turnover at its application site, rather than favoring an anabolic increase in new bone formation (Little et al 2007). Colloss E contains trace amounts of bone growth factors embedded within the lyophilized collagen (van der Zande et al 2006, El-Sabban et al 2007. No conclusions on optimal dose, release rate, or growth factor combinations can be made based on this study.…”

Section: Discussionmentioning

confidence: 90%

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

et al. 2008

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Background and purpose We studied whether osseointegration and fixation of plasma-sprayed titanium implants grafted with β-TCP granules (Ossaplast) can be improved by adding an osteogenic signal (Colloss E). The results were compared to implants grafted with fresh frozen morselized allograft with and without the Colloss E device.Methods 4 porous-coated Ti implants were placed in the proximal humeri in each of 10 dogs. All implants were surrounded by a 2.5-mm defect, which was grafted with: (A) β-TCP, (B) β-TCP + 20 mg Colloss E, (C) allograft, or (D) allograft + 20 mg Colloss E. The observation time was 4 weeks.Results Mechanical testing showed that the β-TCP group with Colloss E was twice as well fixed as the control group grafted with β-TCP granules alone, and comparable to both allograft groups. We found that every control implant in the β-TCP grafted group was covered by a dense fibrous membrane. No fibrous tissue was seen in the β-TCP group augmented with Colloss. These implants were well osseointegrated, with new bone covering 10-25% of the implant surface. Both treated groups had increased graft resorption compared to their respective control groups. Colloss E had no effect on new bone formation or fibrous tissue reduction around the allografted implants.Interpretation The Colloss E device improved early osseointegration of implants grafted with β-TCP granules and increased their mechanical implant fixation to the level of allografted implants. The experiment

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“…This natural material, similar to those of the human bone, shows great osteoconductive properties [6]. There are a few studies on equine-derived bone substitutes [7,8] for filling the bone gap. The material used in the present study was an equine-derived bone substitute material commercially available (Osteoplant-Flex, Bioteck Srl, Arcugnano, Vicenza, Italy), which was deantigenated through a low-temperature (max 37°C) enzymatic process that should not alter its mineral component.…”

Section: Original Papersmentioning

confidence: 99%

Comparison of Autologous and Heterologous Bone Graft Stability Effects for Filling Maxillary Bone Gap After Le Fort I Osteotomy

Eser¹,

Gencel²,

Gökdoğan³

et al. 2015

Adv Clin Exp Med

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Background. The amount of postoperative maxillary relapse of two different bone graft materials after Le Fort I osteotomy were compared in this study. Objectives. The aim of this study is to compare postoperative maxillary relapse rates using heterologous and autologous graft materials after Le Fort I osteotomy. Material and Methods. A total of 80 patients who had developmental malocclusion were analyzed retrospectively in this study. Twenty nine (36.2%) and 51 (63.8%) patients underwent Le Fort I osteotomy, and Le Fort I and bilateral sagittal split ramus osteotomy (two-jaw surgery), respectively. Forty two (52.5%) maxillary bone gaps were filled with heterologous bone grafts (group A) and 38 (47.5%) were filled with autologous bone grafts (group B) after Le Fort I osteotomy. The cephalometric graphics and measurements were taken before (T1), 1 week after (T2), and 1 year after (T3) the surgery. The results were documented and determined by the Dolphin imaging 10.5 (Dolphin Imaging, Chatsworth, Calif.) computer program for skeletal relapse. Whether or not the relationship between group A's and B's maxillary relapse rates was evaluated in the postoperative period. Results. It was observed that both graft materials have positive effects on maxillary relapse rate in the postoperative period. When the groups are compared to each other, the relapse rates were similar between group A (8.3%) and group B (10.8%) (p > 0.05). Conclusions. Heterologous bone graft material (Osteoplant ® -Flex) is thought to be a good alternative to autologous grafts in decreasing the relapse rates and reducing the morbidity of the donor area of the patients who underwent Le Fort I osteotomy (Adv Clin Exp Med 2015, 24, 2, 341-348).

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Xenogenic Bone Matrix Extracts Induce Osteoblastic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Cited by 35 publications

References 41 publications

An overview on bone protein extract as the new generation of demineralized bone matrix

An overview on bone protein extract as the new generation of demineralized bone matrix

Ceramic bone graft substitute with equine bone protein extract is comparable to allograft in terms of implant fixation: A study in dogs

Comparison of Autologous and Heterologous Bone Graft Stability Effects for Filling Maxillary Bone Gap After Le Fort I Osteotomy

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