Xanthogranulomatous Pyelonephritis is Associated with Higher Tissue Expression of Monocyte Chemotactic Protein-1

Bartoli, Fabio; Gesualdo, Loreto; Niglio, Francesco; Gentile, Ottavio; Penza, R; Leggio, Samuele; Lasalandra, Carla; Campanella, Vittoria; Magaldi, Simona

doi:10.1055/s-2007-965534

Cited by 7 publications

(4 citation statements)

References 11 publications

(18 reference statements)

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“…MCP-1, a key chemokine, initiates chemotaxis due to which migration and accumulation of macrophages occurs at the site. [ 35 ] Other inflammatory cells including lymphocytes and plasma cells also accompany the macrophages. It has been documented in orbital xanthogranulomatous disease that TIMP signaling pathway is activated in macrophages by stimulating the phosphorylation of JAK2 and STAT3.…”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous epididymo-orchitis: A single-institutional case series and systematic review

2023

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Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous epididymo-orchitis: A single-institutional case series and systematic review

2023

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“…Indeed, cholesterol is a known activator of the danger sensing structure, NLRP3 inflammasome, in macrophages, which orchestrates production of certain inflammatory cytokines [24]. In xanthogranulomatous pyelonephritis, increased monocyte chemotactic protein-1 expression has been suggested to play an important role in its pathogenesis [25]. A monocyte/macrophage typically transforms into foamy macrophage under the stimulus of IL-6, TNF-alpha and M-CSF [26].…”

Section: Discussionmentioning

confidence: 99%

Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation

Taşkin

Güçer

Winer

et al. 2015

Head and Neck Pathol

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Xanthogranulomatous inflammation (XGI) is an uncommon destructive chronic inflammatory process mainly occurring in the kidney and gallbladder, characterized by the accumulation of foamy histiocytes, multinucleated giant cells (Touton type), cholesterol clefts and chronic inflammatory cells. The head and neck region is an uncommon site for XGI. This type of inflammatory reaction has been defined in branchial cleft cyst, salivary gland tumors following fine-needle aspiration biopsies, Rathke's cleft cyst in the pituitary gland, and colloid cyst in the 3rd ventricle. We present herein a unique case of ruptured thyroglossal duct cyst leading to XGI, characterized by an infiltrative subcutaneous central neck lesion, clinically mimicking a thyroid carcinoma. In addition, we also summarize current insights into the pathogenesis of XGI in the head and neck region.

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“…Данные литературы о роли ЕGF при заболеваниях почек противоречивы. Большинство из них позволяют сделать вывод о значительной роли EGF, синтезируемого тубулярными элементами, в патогенезе тубулоинтерстициального повреждения [41][42][43][44]. Активация EGFR с повышением экспрессии EGF способствует развитию и прогрессированию заболеваний почек в различных экспериментальных моделях на животных.…”

Section: уровни цитокинов мочи в зависимости от состояния концентрациunclassified

Urine Cytokines Are Noninvasive Markers of Clinical and Laboratory Remission in Children With Chronic Pyelonephritis

Слободян

Каладзе

Говдалюк

2017

Nefrologiâ (St.-Peterbg.)

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THE AIM: to evaluate diagnostic significance of clinical and laboratory resistance in determining urine cytokines in patients with chronic pyelonephritis (CP). PATIENTS AND METHODS. This prospective study included 110 children with CP aged 6 to 16 years in a state of clinical and laboratory remission. The control group consisted of 20 apparently healthy children. Laboratory tests used to determine EGF, TGF-β1, IGF-1, β2 – MG, IL-4, IL-10, IL-17 and IL-12 by ELISA in the morning urine of patients. RESULTS. Comparison of cytokines values depending on the clinical form of the disease revealed the prevalence of levels of TGF-β1 and IL-17 in the urine of patients with obstructive CP. The highest uTGF-β1 / uCr and uIL-17 / uCr were obtained in patients, which have vesicoureteral reflux in anamnesis. Level uIL-10 / uCr almost 2 times was elevated in children with both clinical forms of CP. In patients with the disease experience up to 6 years, were identified unidirectional changes of urine cytokines – increase in both pro- and anti-inflammatory parameters. As the duration of the microbial-inflammatory processes more than 6 years there was a significant decrease in the levels uIGF-1 / uCr and uEGF-1 / uCr relative to the control group, with no significant changes in the uIL-12 / uCr and uIL-10 / uCr at continuing higher levels uTGF-β1 / uCr, uIL-17 / uCr, uIL-4 / uCr. In patients having one or less exacerbation of CP per year, regardless of the duration of the disease, no pathological changes in cytokine levels have been detected. Most of the studied parameters were dependent on renal function. CONCLUSION. Increased concentration of studied urine cytokines indicates the presence of a latent inflammatory process more than in half of studied patients.

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Xanthogranulomatous Pyelonephritis is Associated with Higher Tissue Expression of Monocyte Chemotactic Protein-1

Abstract: MCP-1 would seem to play a key role in the pathogenesis of XGP by mediating the recruitment of circulating monocytes or by cells resident in the interstitial space.

Cited by 7 publications

References 11 publications

Xanthogranulomatous epididymo-orchitis: A single-institutional case series and systematic review

Xanthogranulomatous epididymo-orchitis: A single-institutional case series and systematic review

Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation

Urine Cytokines Are Noninvasive Markers of Clinical and Laboratory Remission in Children With Chronic Pyelonephritis

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