The psychomotor development of children is a complex parameter for their body formation and a diagnostically reliable method for assessing mental and somatic health. At present, the number of newborns is increasing, especially among premature children, who develop serious neurological problems that were initially determined by a delay in psychomotor development and were regarded as morphological and functional features of an immature child. In our country and abroad, there are various methods of eliminating the consequences of cerebral ischemia. In connection with this problem, we have treated patients with hydrotherapy and evaluated the results of the study on the Bayley scale for a comprehensive characteristic of motor and mental development. The obtained data also made a significant contribution to abilitation measures aimed at preventing cerebral ischemia consequences.
THE AIM: to evaluate diagnostic significance of clinical and laboratory resistance in determining urine cytokines in patients with chronic pyelonephritis (CP). PATIENTS AND METHODS. This prospective study included 110 children with CP aged 6 to 16 years in a state of clinical and laboratory remission. The control group consisted of 20 apparently healthy children. Laboratory tests used to determine EGF, TGF-β1, IGF-1, β2 – MG, IL-4, IL-10, IL-17 and IL-12 by ELISA in the morning urine of patients. RESULTS. Comparison of cytokines values depending on the clinical form of the disease revealed the prevalence of levels of TGF-β1 and IL-17 in the urine of patients with obstructive CP. The highest uTGF-β1 / uCr and uIL-17 / uCr were obtained in patients, which have vesicoureteral reflux in anamnesis. Level uIL-10 / uCr almost 2 times was elevated in children with both clinical forms of CP. In patients with the disease experience up to 6 years, were identified unidirectional changes of urine cytokines – increase in both pro- and anti-inflammatory parameters. As the duration of the microbial-inflammatory processes more than 6 years there was a significant decrease in the levels uIGF-1 / uCr and uEGF-1 / uCr relative to the control group, with no significant changes in the uIL-12 / uCr and uIL-10 / uCr at continuing higher levels uTGF-β1 / uCr, uIL-17 / uCr, uIL-4 / uCr. In patients having one or less exacerbation of CP per year, regardless of the duration of the disease, no pathological changes in cytokine levels have been detected. Most of the studied parameters were dependent on renal function. CONCLUSION. Increased concentration of studied urine cytokines indicates the presence of a latent inflammatory process more than in half of studied patients.
Physiotherapeutic procedures normalize physicochemical processes at the cellular and molecular levels. The complex application of natural factors for reducing the interference of the leading pathological focus and deviations of other localization, including the maxillofacial region is actual. The purpose of the study is the development of a therapeutic and prophylactic dental complex for patients with juvenile rheumatoid arthritis (JRA) staying in sanatorium. Material and methods. 30 patients with JRA in the Evpatoriya were examined. Patients of the comparison group receved standart therapy. Patients of the main group additionally received bioresonance stimulation (BRS) of the collar zone and projection of large salivary glands; the oral cavity was rinsed with a solution of the brine from Saky’s Lake. Dental indices, rate of salivation, saliva viscosity, cortisol and ACTH in oral fluid and blood were determined. Results. The effectiveness of dental care in resort conditions was noted in both groups, but the reduction of rate of salivation and viscosity of oral fluid was more dynamic (on 31,58% and 15,6%), reflecting the ability of the BRS to regulate functional activity salivary glands. Cortisol in the OF decreased, which indirectly indicated the physiological activity of the excretory apparatus of the salivary glands at the level of transport molecular metabolism. Conclusions. Staying patients with JRA in the sanatorium-resort conditions in Evpatoriya has a general health effect. “Small” balneotherapy of the brine from Saky’s Lake improves oral hygiene. BRS-therapy restores the functional activity of salivary glands, promotes regulation of cortisol and ACTH levels. Providing rehabilitation dental care for patients with JRA, in the conditions of the resort is justified.
В обзоре представлены данные экспериментальных и клинических исследований, доказавших неоспоримое влияние эпифиза и его гормона мелатонина на функциональные особенности почек. В разнообразных животных моделях мелатонин оказывает нефропротекторное действие, способствуя предотвращению негативных воздействий и нормализации структурно-функциональных показателей почек. Клинические испытания показали, что у пациентов с хронической болезнью почек, подверженных длительному воспалительному прессингу и высокому уровню окислительного стресса, приводящему к деградации почечной ткани и ухудшению ее функционального состояния, эффективен прием экзогенного мелатонина, обладающего мощным антиоксидантным, апоптозорегулирующим и иммуномодулирующим эффектами. Приведены данные собственных исследований, свидетельствующие о нарушении продукции и циркадианного ритма секреции мелатонина у детей, страдающих хронической болезнью почек, прогрессирующей на фоне обструктивного хронического пиелонефрита. Определяли пиковые значения уринарного 6-сульфатоксимелатонина. С увеличением длительности микробно-воспалительного поражения почек, частоты обострений, снижением функциональных показателей наблюдали снижение ночного пикового значения 6-ульфатоксимелатонина и увеличение дневного показателя. Вероятно, данные изменения можно рассматривать как один из модифицируемых факторов риска дебюта и прогрессирования хронической болезни почек, что, несомненно, нуждается в дальнейшем исследовании и обсуждении.
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