Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation

Taşkin, Orhun Çığ; Güçer, Hasan; Winer, Daniel A.; Mete, Özgür

doi:10.1007/s12105-015-0628-y

Cited by 7 publications

(11 citation statements)

References 26 publications

(40 reference statements)

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“…Consensus regarding the best strategy in treating isolated neck XGI has not been reached due to the rarity of the disease. [ 5 , 7 , 9 – 11 , 13 – 16 , 20 – 22 ] After comprehensively reviewing previous publications, we found that neck XGI management mostly relied on curative surgical excision. [ 7 , 9 – 11 , 13 – 16 , 20 – 22 ] A wide open surgical field might be needed in cases where inflammation extends to adjacent tissues.…”

Section: Discussionmentioning

confidence: 99%

“…[ 11 ] Differentiation entities include other benign histiocytic pathologies, such as dendritic cell disorders (further divided into Langerhans cell histiocytosis and non-Langerhans cell histiocytosis) and macrophage cell disorder (e.g., hemophagocytic lymphohistiocytosis, Rosai–Dorfman disease). [ 3 , 20 ] It is worth noting that previous studies have found association between IgG4-related disorders (IgG4-RD) and XGI because IgG4-positive plasma cells may present as a nonpredominant cell population in XGI. In Hong's study that looked at 57 resected xanthogranulomatous cholecystitis, they found that XGI occasionally coincides in patients with already known IgG4-RD.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 , 7 , 9 – 11 , 13 – 16 , 20 – 22 ] After comprehensively reviewing previous publications, we found that neck XGI management mostly relied on curative surgical excision. [ 7 , 9 – 11 , 13 – 16 , 20 – 22 ] A wide open surgical field might be needed in cases where inflammation extends to adjacent tissues. [ 7 , 9 – 11 , 13 – 16 , 20 – 22 ] Efficacies of other widely employed alternatives in orbit XGI, such as steroid, immune-suppressants, or chemotherapies remained unclear.…”

Section: Discussionmentioning

confidence: 99%

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Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus

Chen

Liu³

et al. 2018

Medicine

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Rationale:Xanthogranulomatous inflammation (XGI) is a rare inflammatory process, which mostly affects the kidney and gallbladder. It usually simulates an aggressive neoplastic process. Occurrences in the neck are extremely rare and would usually be associated with a preexisting cyst or glandular tissues.Patient concerns:A 49-year-old diabetic patient presented with a right painful neck mass for a week. The pretreatment computed tomography (CT) imaging with contrast demonstrated a huge ill-defined heterogeneous-enhanced lesion abutting surrounding musculatures and great vessels. Both fine needle aspiration (FNA) and ultrasound-guided core biopsy of the neck mass showed inflammatory cells only.Diagnoses:Histologic evaluation found granulation tissue with histiocytes and occasional Touton giant cells confirming the diagnosis of xanthogranuloma.Interventions:Open excisional biopsy demonstrated a yellowish mass-like lesion with abscess inside.Outcomes:The patient recovered from the disease without posttreatment comorbidities.Lessons:This case highlights the need for physicians to maintain awareness of this clinical entity and delayed- or overtreatment should be avoided in these patients due to preoperative ambiguous diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus

Chen

Liu³

et al. 2018

Medicine

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“…Xanthogranulomatous inflammation is histopathologically characterized by a marked proliferative fibrosis, parenchymal destruction, and infiltration of foamy histiocytes intermixed with other inflammatory cells . There have been only a few cases of XGI reported in the head and neck, and periocular xanthogranuloma has also been reported . This disease is very difficult to diagnose and is sometimes mistaken for malignant tumor …”

Section: Discussionmentioning

confidence: 99%

“…Its characteristic histology includes formy histiocytes and giant cells. The head and neck region is an uncommon site for XGI, with only three cases having been reported to date . Two of these cases were cystic in origin.…”

Section: Introductionmentioning

confidence: 99%

A case of neck xanthogranulomatous inflammation‐suspected malignant tumor

Nomura

Momose

Takashima

et al. 2019

Clinical Case Reports

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Xanthomatous Hypophysitis Is Associated with Ruptured Rathke’s Cleft Cyst

et al. 2017

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Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evidence suggests that pituitary inflammation may occur as a secondary reaction to mucous content released from a ruptured cyst. In a series of 1221 pituitary specimens, we identified seven cases of xanthomatous hypophysitis. Six patients had complete radiological and biochemical workup preoperatively: a cystic-appearing pituitary mass was identified in all six patients (100%) with a mean size of 2.0 cm (range 1.4-2.5 cm) on imaging, and pituitary endocrine dysfunction was noted in five patients (83.3%). In all cases, the pituitary mass was resected through an endoscopic transsphenoidal approach. Pathological examination revealed the presence of foamy macrophages admixed with variable amounts of giant cells and chronic inflammatory cells, confirming the diagnosis of xanthomatous hypophysitis. Additionally, all cases presented with concurrent findings of ruptured Rathke's cleft cyst, with the exception of one patient who had previous surgery for a Rathke's cleft cyst, followed by recurrence and diagnosis of xanthomatous hypophysitis. While accurate distinction of hypophysitis from a pituitary neoplasm can be problematic in the preoperative setting, the identification of a cystic lesion in the sella turcica should raise the possibility of such an entity in the clinical and radiological differential diagnosis. The current series provides further evidence that xanthomatous hypophysitis predominantly occurs as a secondary reaction to a ruptured Rathke's cleft cyst; thus, it is best classified as a secondary (reactive) hypophysitis.

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Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation

Cited by 7 publications

References 26 publications

Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus

Neck xanthogranuloma mimicking malignancy in a patient with diabetes mellitus

A case of neck xanthogranulomatous inflammation‐suspected malignant tumor

Xanthomatous Hypophysitis Is Associated with Ruptured Rathke’s Cleft Cyst

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