Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway

Does pomegranate consumption affect weight and body composition? A systematic review and meta‐analysis of randomized controlled clinical trials

“…A study by Abidov et al showed that xanthigen leads to weight loss and reduced body fat percent among obese participants (Abidov et al, ). Indeed, Xanthigen acts its role by inhibition of proliferator‐activated receptor expression and activation of the AMPK signaling pathway in adipose tissue (Choi et al, ).…”

“…It was observed that antioxidant supplementation has been associated with a reduction in adiposity and improvement in glucose tolerance among pregnant rats (Sen & Simmons, 2010 2010). Indeed, Xanthigen acts its role by inhibition of proliferatoractivated receptor expression and activation of the AMPK signaling pathway in adipose tissue (Choi et al, 2014).…”

Health Benefits of Punicic Acid: A Review

“…In vitro , the 2 molecules show some degree of synergism in pro‐fat loss effects. Choi and others () reported the possible attenuation of HFD‐induced obesity by xanthigen (1%) in C57BL/6N mice. The food efficiency ratio and body weight were significantly reduced compared to the HFD‐fed control, followed by a significant decrease in weights of epididymal and retroperitoneal adipose tissues and the liver and serum LDL‐cholesterol.…”

Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans

“…In our study in transgenic C. elegans, we move forward investigating the molecular mechanisms underlying the antilipogenic effect of Xanthigen® and we confirmed that Xanthigen® reduces lipid deposition through sir-2.1 pathway regulation. Choi et al (2014) 17 reported that Xanthigen® treatment significantly decreased body weight and adipose tissue in mice subjected to a high fat diet through down-regulation of PPARɣ and upregulation of AMPK pathway. Similarly, in a preadipocyte differentiation model it was also demonstrated that Xanthigen® reduces lipid accumulation and suppresses adipocyte differentiation by mechanisms that involve an increase of intracellular levels of AMPK and SIRT1 levels, and a concomitant decrease in PPARɣ 16 .…”

“…Lai et al (2012) 16 reported that Xanthigen® suppressed accumulation of lipid droplets in differentiated 3T3-L1 adipocytes by modulating signaling pathways including Akt-dependent FoxOs signaling, as well as induction of Sirtuin-I (SIRT1). Similarly, Choi et al (2014) 17 reported that the anti-obesity activity of Xanthigen® in high-fat diet-fed mice was associated with a decreased expression of PPARɣ, and 3hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and an increased activation of AMP-activated protein kinase (AMPK) α and β, and Acetyl-CoA carboxylase (ACC), with a reduction of leptin level and expression in adipose tissue and also the body weight. Sirtuins are NAD+-dependent protein deacetylases that are broadly conserved from bacteria to humans, and are involved in longevity and stress resistance.…”