X-ray scattering for the characterization of lyophilized breast tissue samples

Elshemey, Wael M.; Mohamed, Fayrouz S.; Khater, Ibrahim

doi:10.1016/j.radphyschem.2013.04.019

Cited by 13 publications

(7 citation statements)

References 37 publications

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“…In medical applications, several studies [23][24][25][26] have shown that there exist significant differences in the scatter signatures from cancerous and healthy tissue, for example in the blood [2], bone [27] and breast [28]. In addition, studies have shown that scatter imaging can be used to spatially resolve different materials using tomography [29,30] or coded apertures [31].…”

Section: Potential Applications Of X-ray Scatter Imagingmentioning

confidence: 99%

“…The concept of X-ray scatter imaging has been investigated for material identification based on coherent scatter information for medical [1][2][3] and homeland security [4,5] applications. These studies have shown that scattered X-rays can provide higher signal-to-noise ratios (SNR) in identifying certain tissue types (medical) and sensitive materials (homeland security) than is currently possible using transmitted X-rays.…”

Section: Introductionmentioning

confidence: 99%

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An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

Lakshmanan

Kapadia

Sahbaee

et al. 2014

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Potential Applications Of X-ray Scatter Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

Lakshmanan

Kapadia

Sahbaee

et al. 2014

Nuclear Instruments and Methods in Physics Research Section B:

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“…Many pieces of physical and chemical information on samples are contained in scattered X-rays and can be obtained through quantitative analysis of intensity, energy loss, and scattering angles. To date, both kinds of scattered X-rays are widely used in various fields such as the medical 1–4 and foods fields 5 as well as for historical samples 6 to obtain internal information such as on density and structure. In addition, it was reported that the ratio of the intensities of elastic and inelastic scattered X-rays depends on the effective atomic number ( Z eff ) 7–9 , and the Z eff of biomedical samples and oils were determined in an example application 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Novel Zeff imaging method for deep internal areas using back-scattered X-rays

Yoneyama

Kawamoto

Baba

2019

Sci Rep

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Elemental kinds, composition ratios, effective atomic number (Zeff), and spatial distributions are the most basic information on materials and determine the physical and chemical properties of materials. X-ray fluorescence analysis have conventionally been used for elemental mapping, however maps on deep internal areas cannot be obtained because the escape depth of fluorescence X-rays is limited to a few mm from the surface of samples. Herein, we present a novel Zeff imaging method that uses back-scattered X-rays. The intensity ratio of elastic and inelastic back-scattered X-rays depends on the atomic number (Z) of a single-element sample (Zeff for a plural-element sample), and so Zeff maps in deep areas can be obtained by spectrum analysis of the scattered high-energy incident X-rays. We demonstrated the feasibility of observing a phantom covered by an aluminum plate by using synchrotron radiation X-ray. A fine Zeff map that can be used to identify materials was obtained from only front-side observation. The novel method opens up a new way for Zeff mapping of deep areas of thick samples from front-side observation.

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“…Secondary screening methods have other major issues; for example, histopathology requires tissue removal from a patient (Elshemey et al 2013), fixing, staining, and other labor intensive steps (Dahlstrom et al 1996). Small-angle x-ray scatter imaging produces scatter profiles closely correlated to the presence of malignancies in breast tissues (Fernández et al 2002, 2005, Cunha et al 2006, Oliveira et al 2008), without use of a contrast agent.…”

Section: Introductionmentioning

confidence: 99%

Small-angle scatter tomography with a photon-counting detector array

et al. 2016

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Small-angle x-ray scatter imaging has a high intrinsic contrast in cancer research and other applications, and provides information on molecular composition and micro-structure of the tissue. In general, the implementations of small-angle coherent scatter imaging can be divided into two main categories: direct tomography and angular dispersive computerized tomography. Based on the recent development of energy-discriminative photon-counting detector array, here we propose a computerized tomography setup based on energy-dispersive measurement with a photon-counting detector array. To show merits of the energy-dispersive approach, we have performed numerical tests with a phantom containing various tissue types, in comparison with the existing imaging approaches. The results show that with an energy resolution of ~6 keV, the energy dispersive tomography system with a broadband tabletop x-ray would outperform the angular dispersive system, which makes the x-ray small-angle scatter tomography promising for high-specificity tissue imaging.

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X-ray scattering for the characterization of lyophilized breast tissue samples

Cited by 13 publications

References 37 publications

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

Novel Zeff imaging method for deep internal areas using back-scattered X-rays

Small-angle scatter tomography with a photon-counting detector array

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