Wybrane cytokiny prozapalne, metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u dziewcząt z jadłowstrętem psychicznym

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

“…This is in contrast to normal-weight adolescents, who have increased levels of bone metabolism markers, particularly in earlier puberty, consistent with increased bone modelling [15]. On the other hand, serum sRANKL [25][26][27][28][29][30][31] and/or OPG levels [23][24][25][26][27][28][29][30][31] are significantly increased in girls with AN while the OPG/sRANKL ratio is significantly decreased [32,[25][26][27][28][29][30][31]. MunozCalvo et al [32] were the only researchers who did not find significant changes in OPG levels in girls with AN who exhibited a significantly increased sRANKL level and OPG/sRANKL suppression.…”

“…Pomeroy et al [38] found significant elevation of TGF-β, while Corcos et al [39] found a significant decrease of TGF-β2, in young women with AN compared to the control participants. All these data [2,7,8,36], along with our previous results [25][26][27][28][29][30][31], indicate that the abnormal TGF-β concentrations in women with AN demonstrated by several authors [38,39] might promote the development of osteoporosis in these patients, possibly through OPG and/or RANKL. To the best of our knowledge, the relationship between potential changes in TGF-β1 concentrations and bone markers in girls with AN has not been studied so far.…”

“…hormones [15,[33][34][35], but also cytokines including anti-and proinflammatory cytokines [5,30,36]. Considering the fact that TGF-β1, a ubiquitous growth factor, is not a pro-but an anti-inflammatory cytokine that controls both osteoblast and osteoclast differentiation, and therefore balances between bone formation and resorption [2,7,8], it might be expected that possible disturbances in its production could have some role in the mechanism leading to the development of osteoporosis in adolescents with AN.…”

“…Several studies have reported a positive relationship between body mass, body mass index (BMI), and/or bone mineral density (BMD) in adolescents with AN [15,[17][18][19][20][21][22]. Adolescents with AN also have lower levels of biochemical markers of bone formation and resorption than normal-weight controls, indicating a decrease in bone turnover [15,[23][24][25][26][27][28][29][30][31]. This is in contrast to normal-weight adolescents, who have increased levels of bone metabolism markers, particularly in earlier puberty, consistent with increased bone modelling [15].…”

“…MunozCalvo et al [32] were the only researchers who did not find significant changes in OPG levels in girls with AN who exhibited a significantly increased sRANKL level and OPG/sRANKL suppression. Our previous studies [26][27][28][29][30][31] indicate some desynchronisation between the RANKL/RANK/OPG system and bone remodelling (especially bone resorption) in girls with AN.…”