Wound healing properties, antimicrobial and antioxidant activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher &amp; Rech. f. var. euphratica on excision and incision wound models in diabetic rats

Güzel, Sevda; Özay, Yusuf; Kumaş, Meltem; Uzun, Coşar; Özkorkmaz, Ebru Gökalp; Yıldırım, Zühal; Ülger, Mahmut; Güler, Gizem; Çelık, Ayla; Çamlica, Yusuf; Kahraman, Ahmet

doi:10.1016/j.biopha.2019.01.038

Cited by 49 publications

(42 citation statements)

References 52 publications

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“…Mineral content of S. hispanica seeds which are also known as chia was investigated previously and results showed that seeds contain different minerals such as K, Mg, Ca, Na, Fe, Zn, Mn, Cu, Co, Ni, and Se. K (13,477.61 ± 56.27 mg/100 g), Mg (4963.81 ± 31.80 mg/100 g), and Ca (4221.89 ± 232.44 mg/100 g) were determined as major minerals [9]. Besides these minerals, the presence of Mo and P was shown in previous studies [8,11].…”

Section: Discussionmentioning

confidence: 65%

“…Effect of DMSO on microbial growth was tested, no effect determined. The minimal inhibitory concentration (MIC) values were detected in duplicate tests [13].…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…For having positive results, the color changes indicating growth had to be comparable to that seen in the positive growth control. The lowest concentration which prevented full color changes of resazurin was determined as the MIC value [13].…”

Section: Antimycobacterial Activitymentioning

confidence: 99%

“…Experiments were performed in duplicate and visually detected results were noted. The lowest concentration that inhibited growth of the studied microorganism was determined as a MIC value [13,38].…”

Section: Antifungal Activitymentioning

confidence: 99%

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Morphology, myxocarpy, mineral content, and in vitro antimicrobial and antiproliferative activities of mericarps of the vulnerable Turkish endemic Salvia pilifera

Güzel¹,

Kahraman²,

Ülger³

et al. 2019

jrp

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Salvia L., the largest genus of the family Lamiaceae, is composed of many well-known plants of medicinal value. This study provides the first data on micromorphology, myxocarpy, mineral content and in vitro antimicrobial and antiproliferative activities of mericarps of Salvia pilifera, considered to be a vulnerable endemic species from Turkey. The macro-and micromorphological mericarp traits were documented and illustrated via stereo microscopy and scanning electron microscopy. Mineral content of mericarps was analyzed using ICP-MS. Ethanol extract of mericarps was tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Acinetobacter baumannii, Aeromonas hydrophila, Candida albicans, Candida tropicalis, and Candida glabrata using broth microdilution method. Antimycobacterial activity was performed against Mycobacterium tuberculosis H37Rv using resazurin microtiter plate method. Ampicillin, Ethambutol, Isoniazid, and Fluconazole were chosen as reference drugs. Antiproliferative effect of the extract was tested against A549 human lung cancer cell lines using MTT test. The size of the mericarps was 4.38±0.17 mm in length and 3.28±0.13 mm in width. The general shape was elliptic to widely elliptic. The abscission scar was nearly rounded. The ornamentation pattern of the surface was colliculate with polygonal exocarp cells. Myxocarpy was observed on the surface of the mericarps when they become hydrated. Transparent mucilaginous cells showed a moderate reaction with extensions more than 0.1 mm long. Potassium and calcium were determined as major minerals (80.662±0.234 and 41.892±0.399 µg/g, respectively). The extract showed greater antibacterial activity against A. baumannii compared to Ampicillin (62.5 and 125 µg/mL MIC values, respectively). Cell viability level of the extract (100 μg/mL) was found to be statistically lower than control group against A549 human lung cancer cell lines (P<0.05).

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Section: Discussionmentioning

confidence: 65%

“…Effect of DMSO on microbial growth was tested, no effect determined. The minimal inhibitory concentration (MIC) values were detected in duplicate tests [13].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Antimycobacterial Activitymentioning

confidence: 99%

Section: Antifungal Activitymentioning

confidence: 99%

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Morphology, myxocarpy, mineral content, and in vitro antimicrobial and antiproliferative activities of mericarps of the vulnerable Turkish endemic Salvia pilifera

Güzel¹,

Kahraman²,

Ülger³

et al. 2019

jrp

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“…After the solvent was evaporated, 2.1 g of extract was obtained. OMW extracts were tested for antioxidant activity using a stable free radical DPPH as test [13,16]. The result of DPPH scavenging activity for each sample concentration was given as percentage (Fig.…”

Section: Antioxidant Activity Of Phenolic Extracts and Nmr Results Ofmentioning

confidence: 99%

Degradation of olive mill wastewater by different methods and antioxidant activity of olive mill wastewater extraction

et al. 2019

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Olive wastewater (OMW) is an important environmental problem due to the high phenol level and contains organic substances such as sugars, organic acids, polyalcohols, pectins, colloids, tannins, and lipids. Removing OMW is difficult because of the high concentrations of chemical oxygen demand (COD), biochemical oxygen demand, and phenolic compounds. In this study, we concentrated on the degradation of OMW to solve this problem. The degradation of OMW at high pressure and temperature (with H 2 O 2 and without H 2 O 2), at room temperature and atmospheric pressure with H 2 O 2 , at room temperature and atmospheric pressure with O 3 , and with ultrasound-assisted ozonation, was investigated by means of COD, phenolic compounds, and sulfur analyses. The results showed that the method of high pressure and temperature with H 2 O 2 was the most successful. H 2 O 2 at high pressure (O 2) and temperature removed 89.2% of COD, 91.5% of phenolic compounds, and color of OMW. With this result, we showed that the use of O 2 atmosphere instead of N 2 is important for degradation and also especially for color removing. In addition, the antioxidant property of OMW was also examined. Fourier-transform infrared spectroscopy of the extracts revealed vibration bands corresponding to acid, alcohol, and ketone groups. The results showed that high pressure and temperature treatment is very effective for removing phenolic compounds from olive oil wastewater. In addition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging potential of OMW in the Çukurova area of Turkey was studied and the IC 50 value of OMW was determined to be 118 µg/mL.

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Synthesis of Schiff Bases and Secondary Amines with Indane Skeleton; Evaluation of Their Antioxidant, Antibiotic, and Antifungal Activities

Erdoğan

Yılmaz

Çevik

et al. 2023

Chemistry & Biodiversity

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In this study, Schiff bases were synthesized by utilizing the reaction of 4‐ and 5‐aminoindane with substituted benzaldehydes. After the reduction of isolated Schiff bases with NaBH4, the corresponding secondary amine derivatives were obtained. The structures of all synthesized molecules were confirmed by 1H‐NMR, 13C‐NMR, FTIR, and ESI‐MS. Antioxidant activities of all synthesized molecules were investigated by DPPH method, and IC50 values were calculated. In addition, antibacterial activities of targets were investigated by the well diffusion method, and then MIC99 values were calculated. While only four of the sixteen synthesized molecules showed a high level of antioxidant activity, all of the molecules exhibited biological activity against gram‐positive and gram‐negative bacteria to varying degrees. In addition, all the synthesized molecules showed high antifungal activity. In antioxidant capacity studies, the IC50 values of 2‐(((2,3‐dihydro‐1H‐inden‐5‐yl)amino)methyl)‐6‐methoxyphenol (4d) and 2‐(((2,3‐dihydro‐1H‐inden‐4‐yl)amino)methyl)‐6‐methoxyphenol (7d) were determined to be 18.1 µg and 35.1 µg, respectively, and these values are much stronger than BHT (butylated hydroxytoluene) and BHA (butylated hydroxyanisole) used as positive controls. The fact that targets have the same core structure with different substituents has revealed a good structure‐activity relationship.

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Wound healing properties, antimicrobial and antioxidant activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica on excision and incision wound models in diabetic rats

Cited by 49 publications

References 52 publications

Morphology, myxocarpy, mineral content, and in vitro antimicrobial and antiproliferative activities of mericarps of the vulnerable Turkish endemic Salvia pilifera

Morphology, myxocarpy, mineral content, and in vitro antimicrobial and antiproliferative activities of mericarps of the vulnerable Turkish endemic Salvia pilifera

Degradation of olive mill wastewater by different methods and antioxidant activity of olive mill wastewater extraction

Synthesis of Schiff Bases and Secondary Amines with Indane Skeleton; Evaluation of Their Antioxidant, Antibiotic, and Antifungal Activities

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