Synthesis of Schiff Bases and Secondary Amines with Indane Skeleton; Evaluation of Their Antioxidant, Antibiotic, and Antifungal Activities

Abstract

In this study, Schiff bases were synthesized by utilizing the reaction of 4‐ and 5‐aminoindane with substituted benzaldehydes. After the reduction of isolated Schiff bases with NaBH4, the corresponding secondary amine derivatives were obtained. The structures of all synthesized molecules were confirmed by 1H‐NMR, 13C‐NMR, FTIR, and ESI‐MS. Antioxidant activities of all synthesized molecules were investigated by DPPH method, and IC50 values were calculated. In addition, antibacterial activities of targets were investigated by the well diffusion method, and then MIC99 values were calculated. While only four of the sixteen synthesized molecules showed a high level of antioxidant activity, all of the molecules exhibited biological activity against gram‐positive and gram‐negative bacteria to varying degrees. In addition, all the synthesized molecules showed high antifungal activity. In antioxidant capacity studies, the IC50 values of 2‐(((2,3‐dihydro‐1H‐inden‐5‐yl)amino)methyl)‐6‐methoxyphenol (4d) and 2‐(((2,3‐dihydro‐1H‐inden‐4‐yl)amino)methyl)‐6‐methoxyphenol (7d) were determined to be 18.1 µg and 35.1 µg, respectively, and these values are much stronger than BHT (butylated hydroxytoluene) and BHA (butylated hydroxyanisole) used as positive controls. The fact that targets have the same core structure with different substituents has revealed a good structure‐activity relationship.

Modification, Characterization of New Thiazolidinone and Oxazolidinone Derived from Levofloxacin and Evaluation of Anti-Oxidant

“…Physiochemical properties as shown in Table 1. [13,[20][21][22] A mixture of acid hydrazide (0.5 g, 0.0013 mmol) and various aromatic ketones [p-bromo Acetophenone, p-Chloro Acetophenone, p-amino Acetophenone] (0.0013 mol) in methanol (20 mL) and few drops of GAA was refluxed for 8 hours; the precipitate was filtered, washed with diethyl ether to give the final product. The physical properties are listed in Table 1.…”