Wound healing potential of Althaea officinalis flower mucilage in rabbit full thickness wounds

Valizadeh, Robab; Hemmati, Ali Asghar; Houshmand, Gholamreza; Bayat, Sara; Bahadoram, Mohammad

doi:10.1016/j.apjtb.2015.07.018

Cited by 24 publications

(17 citation statements)

References 20 publications

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“…This organization of vascular system provides necessary oxygen and nutrient supplements for wound healing repair [22]. Angiogenesis induction in endothelial cells is mediated by angiogenic factors such vascular endothelial growth factor (VEGF) [29].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, lipid peroxidation is suspected to impair VEGF expression for normal angiogenesis process [35]. Antioxidant agents are effective to combat excessive ROS activity and thus minimize lipid peroxidation [22,25]. TQ has shown to improve endothelial function by reducing oxidative stress [36].…”

Section: Discussionmentioning

confidence: 99%

“…This acute inflammatory response is predominantly a non-specific immune response against infection and injury [20]. Neutrophils and macrophage infiltrations are important in the acute inflammatory phase of wound healing as these cells remove debris and kill bacteria through phagocytosis [21,22]. Moreover, this cascade is important to prepare the wound bed for subsequent recruitment and proliferation of cells; however, excessive inflammatory response will impair tissue granulation processes such as angiogenesis [17,23].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented. Methods:In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats. Conclusions:Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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“…The wound-healing effects of A. officinalis were confirmed in a Wistar male rats animal model [27]. A. officinalis ointment (15%) enhanced wound healing by reducing the wound-healing time in a rabbit animal model compared to the 1% phenytoin ointment-treated group [45].…”

Section: Anti-inflammatory and Immune-modulatory Effects Of A Officimentioning

confidence: 99%

Marsh Mallow (<b><i>Althaea officinalis</i></b> L.) and Its Potency in the Treatment of Cough

Mahboubi¹

2019

Complement Med Res

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Althaea officinalis has been traditionally used for manage ment of cough and other respiratory problems. The aim of this review article was to evaluate its efficacy in modern re search according to its traditional beliefs. All information was extracted from scientific resources of PubMed Central, ScienceDirect, Wiley, Springer, SID, accessible books, re ports, and theses. The results of animal and clinical studies confirmed the efficacy of A. officinalis extracts alone in treat ment of dry cough, while combination of A. officinalis with Zataria multiflora, Zingiber officinalis, or Helix hedera in creased the efficacy of A. officinalis and improved all kinds of cough. Different mechanisms are involved in expectorant and antitussive effects of A. officinalis in treatment of cough. Therefore, A. officinalis in combination with other plant ex tracts in different forms of drug could be a good choice for cough, sore throat, and other respiratory ailments. Echter Eibisch (Althaea officinalis L.) und seine Wirksamkeit in der Behandlung von HustenSchlüsselwörter Althaea officinalis · Husten · Rhamnogalacturonan · Expektorans · Antitussivum Zusammenfassung Althaea officinalis wird seit jeher zur Behandlung von Hus ten und anderen Atemwegsproblemen eingesetzt. Ziel des vorliegenden Artikels war die Beurteilung der Wirksamkeit entsprechend den überlieferten Überzeu gungen gemäß den Ergebnissen der modernen For schung. Sämtliche Informationen wurden wissenschaftli chen Quellen von PubMed Central, ScienceDirect, Wiley, Springer, SID, einsehbaren Büchern, Berichten und Dok torarbeiten entnommen. Die Ergebnisse der tierexperi mentellen Untersuchungen und klinische Studien beleg ten die Wirksamkeit von A. officinalisExtrakten als Mono therapie zur Behandlung von trockenem Husten, während die Kombination von A. officinalis mit Zataria multiflora, Zingiber officinalis oder Helix hedera die Wirksamkeit von A. officinalis erhöhte und bei verschiedenen Arten von Husten zu einer Besserung führte. An den schleimlösen den und hustenstillenden Effekten von A. officinalis in der Behandlung von Husten sind verschiedene Mechanismen beteiligt. Daher kann A. officinalis in Kombination mit an deren Pflanzenextrakten in verschiedenen Arzneimittel formen eine gute Wahl bei Husten, Halsschmerzen und Atemwegserkrankungen darstellen.

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“…A variety of mechanisms of action have been proposed for T-2 toxin, which reacts with the thiol groups of sulfhydryl enzymes and inhibits protein and DNA synthesis (4), as well as impairs the production of antibodies, alters membrane functions, reduces lymphocyte proliferation, and alters the maturation process of dendritic cells (5)(6)(7). Currently, the demand for herbal therapy is increasing and the amount of research being conducted on traditional herbal drugs indicates that many people around the world trust such remedies to alleviate various skin diseases (8). The genus Crataegus belongs to the family Rosaceous comprising a complex group of trees and shrubs that are native to Northern temperate zones, mostly between latitudes 30°and 50°N…”

Section: Introductionmentioning

confidence: 99%

Healing Effect of Hawthorn (Crataegus pontica C. Koch) Leaf Extract in Dermal Toxicity Induced by T-2 Toxin in Rabbit

Kalantari‬

Hemmati

Goudarzi

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: T-2 toxin is a mycotoxin, exposure to which causes dermal and systemic toxicity. Crataegus pontica (a member of the Rosaceous family) is a small tree with caduceus foliage that is widely distributed throughout the western and central areas of Iran. Objectives: This study was performed to examine the healing effects of creams prepared using Crataegus pontica leaf extract on dermal toxicity induced by T-2 toxin. Methods: Iranian rabbits were used for this study. The back left flanks of the animals were shaved and to induce toxicity, a solution

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Wound healing potential of Althaea officinalis flower mucilage in rabbit full thickness wounds

Cited by 24 publications

References 20 publications

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Marsh Mallow (<b><i>Althaea officinalis</i></b> L.) and Its Potency in the Treatment of Cough

Healing Effect of Hawthorn (Crataegus pontica C. Koch) Leaf Extract in Dermal Toxicity Induced by T-2 Toxin in Rabbit

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