Marsh Mallow (&lt;b&gt;&lt;i&gt;Althaea officinalis&lt;/i&gt;&lt;/b&gt; L.) and Its Potency in the Treatment of Cough

Mahboubi, Mohaddese

doi:10.1159/000503747

Cited by 18 publications

(11 citation statements)

References 27 publications

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“…Moreover, marshmallow has expectorant and antitussive effects. A recent review stated that the results of animal and clinical studies confirmed the efficacy of A. officinalis, combined with other plant extracts, in the treatment of cough (73).…”

Section: Althea Officinalismentioning

confidence: 96%

Non-pharmacological remedies for post-viral acute cough

Ciprandi

Tosca

2021

Monaldi Arch Chest Dis

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The post-viral acute cough (PAC) is a widespread symptom, mainly in childhood and adolescence, and is usually associated with an acute upper respiratory infection, namely the common cold. The use of cough relievers is, therefore, impressive, as documented by the market data. There are many medical devices and dietary supplements for treating PAC, which contain non-pharmacological components. Ancient people used traditional herbs to treat PAC. Thus, a well-established tradition considers natural remedies as an effective and safe way to relieve PAC. The herbal agents include polyphenols, flavonoids, saponins, glucosides, and alkaloids. Also, the European Medicine Agency has recognized the value of plant extracts and other natural substances to treat PAC. Nevertheless, a few studies investigated the role of non-pharmacologic remedies for PAC. There is some evidence for honey, glycerol, Althea officinalis, Drosera rotundifolia, Grindelia, Hedera helix, Pelargonium sidoides, Sambucus nigra, Thymus vulgaris, hyaluronic acid, and saline solutions. However, further rigorous studies should confirm natural products' efficacy and safety to relieve PAC.

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Section: Althea Officinalismentioning

confidence: 96%

Non-pharmacological remedies for post-viral acute cough

Ciprandi

Tosca

2021

Monaldi Arch Chest Dis

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“…Indeed, mucilage can prepare polysaccharide layers on inflamed epithelial tissue to protect and rehydrate it. In a recent study, oral administration of rhamnogalacturonan has shown significant effects in reduction of cough frequency and intensity (Mahboubi, 2020). In one in vivo study, rhamnogalacturonan promoted the expectoration and reduced the intensity and frequency of cough attacks (Nosál'ova et al, 1992).…”

Section: Linseed Laooqmentioning

confidence: 99%

Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 Therapy†

et al. 2021

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Coronavirus disease 2019 is a worldwide pandemic resulting in a severe acute respiratory syndrome. Remdesivir is the only FDA-approved drug for hospitalized patients older than age 12. It shows the necessity of finding new therapeutic strategies. Functional foods (FFs) could have co-therapeutic and protective effects against COVID-19 infection. Traditional Persian medicine (TPM), one of the safest and most popular schools of medicine for hundreds of years, has recommended potential FF candidates to manage such a global pandemic. To reveal the potential of TPM in terms of antitussive FFs, traditional Persian pharmacopoeia “Qarabadin-e-Salehi” was searched using the keywords “Soaal” and “Sorfeh.” Also, a search of MEDLINE, PubMed Central, Google Scholar, and Science Direct was performed for the relevant literature published from the inception up to March 2021. A combination of search terms including “cough, antitussive, antioxidant, anti-inflammation, antiviral, COVID-19, mucoactive, mucolytic, expectorant, and mucoregulatory” was also applied. The potential mechanism of action in SARS-CoV-2 infection was discussed. Twelve TPM FFs were found including Laooqs, Morabbas, a Saviq, a soup, and a syrup. They are combinations of two to seven ingredients. Natural compounds of mentioned formulations have the main pharmacological mechanisms including antiviral, anti-inflammatory, antioxidant, antihistamine, bronchodilator, immunomodulatory, and mucoactive effects as well as central or peripheral antitussive activities. FFs are cost-effective, easily accessible, and safe options for both treatment and prevention of COVID-19. They might have positive psychological effects along with their pharmacological effects and nutritional virtues. They could also manage persistent respiratory discomforts after recovery from COVID-19.

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“…Related researches showed the mucilage polysaccharide content of A. officinalis was 6.2%-11.6%. [20] In order to investigate the effectiveness of the mucilage polysaccharides as an anti-tussive and anti-cough agent, the polysaccharides and rhamnogalacturonan isolated from A. officinalis roots and flowers were tested for anti-tussive activity in unanesthetized cats and guinea pigs of both sexes at oral doses of 50 to 100 mg/kg body weight, [21][22][23][24] in a cough induced by mechanical stimulation, both polysaccharides and rhamnogalacturonan significantly reduced the intensity, the frequency and the number of cough efforts from laryngopharyngeal and tracheobronchial areas. The anti-tussive mechanism might be explained as mucilaginous herbs like A. officinalis roots could form a protective film on the respiratory mucosa thereby to prevent it from being stimulated by foreign antigens.…”

Section: Anti-tussive Effectsmentioning

confidence: 99%

Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis

Xue¹,

Xü²,

Tang³

et al. 2021

Med. Res.

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Althaea officinalis (Malvaceae), mainly distributed in Europe and China, is an ornamental, edible and medicinal plant, which is effective in reducing cough and phlegm. To better develop and utilize A. officinalis, 46 kinds of compounds including flavonoids, phenolic acids, steroids, coumarins and other types isolated from this plant are summarized, and their pharmacological effects such as anti-tussive, anti-inflammatory, anti-oxidation, anti-bacterial and anti-fungal activities are discussed in this review.

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Marsh Mallow (<b><i>Althaea officinalis</i></b> L.) and Its Potency in the Treatment of Cough

Cited by 18 publications

References 27 publications

Non-pharmacological remedies for post-viral acute cough

Non-pharmacological remedies for post-viral acute cough

Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 Therapy†

Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis

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