Healing Effect of Hawthorn (Crataegus pontica C. Koch) Leaf Extract in Dermal Toxicity Induced by T-2 Toxin in Rabbit

Kalantari‬, Heibatullah; Hemmati, Ali Asghar; Goudarzi, Mehdi; Forouzandeh, Hossein; Kalantar, Mojtaba; Aghel, Nasrin; Aslani, Moslem Kiyani; Ehsan, Tahere Shamsi

doi:10.17795/jjnpp-35688

Cited by 5 publications

(8 citation statements)

References 20 publications

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“…The mixture of P. ginseng and C. pinnatifida improved procollagen type I expression, diminished matrix metalloproteinase-1 secretion and improved various other human skin values associated with aging, wrinkle formation and moisture (Hwang et al, 2017). Creams with 5-15% of C. pontica leaf extract have a healing effect on dermal toxicity caused by T-2 toxin as it was shown by the study with Iranian rabbits (Kalantari et al, 2016). The penetration of active substances into the full undamaged human skin from the semisolid preparations containing C. oxyacantha extract was evaluated ex vivo.…”

Section: Skin Protective and Other Health Effectsmentioning

confidence: 75%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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Hawthorn (Crataegus spp.) is one of the most famous plants which has been used as natural medicine and nutraceutical. Its phytochemical composition, bioactive compounds and health benefits have been intensively studied and hawthorn preparations may be recognized as classical natural products for cardiovascular health. Polyphenolic compounds of different hawthorn anatomical parts as well as their extracts have been the focus of a majority of these studies, although various other classes of natural health promoting constituents have also been isolated, identified and characterized. Regardless, numerous published reports have particularly focused on the activity mechanisms which are very important for supporting various health benefits. This review summarizes the most recent studies on hawthorn, mainly published since 2015. Search of different databases indicates that approximately 200 publications, which are relevant to phytochemistry and health benefits of Crataegus spp., have appeared since then, most of them have not been included in the existing reviews.

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Section: Skin Protective and Other Health Effectsmentioning

confidence: 75%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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“…Today, Crataegus berries and flowers are officially recognized as herbal raw materials and have been included in European, American, and Canadian pharmacopeias. Recent research confirmed and extended the possibilities of the traditional use of this plant, among others, to anti-inflammatory [ 8 , 9 ], anti-oxidant [ 10 , 11 ], anti-aging [ 12 ], anti-depressant [ 13 ], anti-viral, anti-fungal, anti-bacterial [ 14 ], hypoglycemic, hepatoprotective [ 15 ], gastroprotective [ 16 ], immunostimulatory, hypolipidemic, hypocholesterolemic, and anti-atherosclerotic effects [ 17 ]. Furthermore, Crataegus extracts are considered as putative therapeutic agents for the treatment of hepatocellular carcinoma, breast cancer, melanoma, and colorectal cancer [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

et al. 2021

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Crataegus contains numerous health-promoting compounds that are also proposed to have anti-cancer properties. Herein, we aimed at a contemporaneous evaluation of the effects of polyphenol-rich extracts of berries, leaves, and flowers of six Crataegus species on the viability and invasive potential on the highly aggressive human glioblastoma U87MG cell line. The treatment with the extracts evoked cytotoxic effects, with the strongest in the berry extracts. All extracts not only promoted the apoptosis-related cleavage of poly (ADP-ribose) polymerase 1 (PARP1) but also substantially inhibited the activity of pro-survival kinases, focal adhesion kinase (FAK), and protein kinase B (PKB; also known as Akt), thus indicating the suppression of proliferative and invasive potentials of the examined glioblastoma cells. The qualitative and quantitative characterization of the extracts’ content was also performed and revealed that amongst 37 polyphenolic compounds identified in the examined Crataegus extracts, the majority (29) was detected in berries; the leaf and flower extracts, exerting milder cytotoxic effects, contained only 14 and 13 compounds, respectively. The highest polyphenol content was found in the berries of C. laevigata x rhipidophylla x monogyna, in which flavan-3-ols and phenolic acids predominated. Our results demonstrated that a high content of polyphenolic compounds correlated with the extract cytotoxicity, and especially berries were a valuable source of compounds with anti-cancer potential. This might be a promising option for the development of an effective therapeutic strategy against highly malignant glioblastomas in the future.

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“…All drug solutions with various concentrations were administrated orally (gavage). Also, extracts and γradiation were treated once a day for 70 consecutive days (12,13).…”

Section: Animal Groups and Administration Protocolsmentioning

confidence: 99%

“…The Allium jesdianum (AJ) plant, with proved pharmacological properties, is a native herbal product of Middle East regions (13). The antioxidant features of the biochemical components of AJ (like flavonoids and phenolic) are applied by activation of white blood cells in response to superoxide produced via NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) (14).…”

Section: Introductionmentioning

confidence: 99%

Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

Roshankhah

Zahabi

Gholami

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Allium jesdianum (AJ), as a plant in onion category, has antioxidant features. Moreover, γ-ray potentially generates oxidative stress in living organisms. Objectives: In this study, the probable therapeutic effects of AJ on destruction of pancreas tissue following γ-ray were evaluated. Methods: Sixty-four mature NMRI mice (8 animals in each group) were assigned to eight groups as follows: (1) Control; (2) γ-ray (dose rate of 1 Gy/min); (3-5) AJ extract (500, 1,000, and 2,000 mg/kg); and (6-8) AJ + γ-ray. AJ extract was prepared, and all administrations were applied orally for 70 consecutive days. Antioxidant parameters (nitrite oxide, peroxidation, and ferric reducing ability of plasma (FRAP)), the expression of apoptotic genes (p53 and Bax, by quantitative real-time PCR), and blood concentrations of glucose and insulin were determined biochemically and genetically. Inflammatory cytokines were evaluated by ELISA technique. The number and diameter of Langerhan islets were also studied histologically. Results: In this study, γ-ray increased the levels of all parameters significantly (except for FRAP, insulin, and morphometric parameters, which were reduced) in the γ-ray group compared to the control group (P < 0.05). In the γ-ray and AJ + γ-ray groups, all factors were reduced significantly (except for FRAP, insulin, and morphometric parameters, which were increased) compared to the γ-ray group (P < 0.05). Conclusions: Administration of AJ extract can decrease the damage and radiosensitization in pancreatic cells induced by γ-ray.

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Healing Effect of Hawthorn (Crataegus pontica C. Koch) Leaf Extract in Dermal Toxicity Induced by T-2 Toxin in Rabbit

Cited by 5 publications

References 20 publications

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

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