Wound healing effect of electrospun silk fibroin nanomatrix in burn-model

Ju, Hyung Woo; Lee, Ok Joo; Lee, Jung Min; Moon, Bo Mi; Park, Hyun Jung; Park, Ye Ri; Lee, Min Chae; Kim, Soo Hyeon; Chao, Janet Ren; Ki, Chang Seok; Park, Chan Hum

doi:10.1016/j.ijbiomac.2015.12.055

Cited by 158 publications

(87 citation statements)

References 41 publications

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“…An ideal wound dressing should prevent dehydration of the wound and retain a favorable moist environment at the wound interface, allowing gas permeation as a barrier against dust and microorganisms. Furthermore, it should be nonadhesive, able to be easily removed without trauma, accelerate the wound healing process, and deliver a nearly instantaneous initial dosage of drugs at optimum therapeutic concentrations …”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it should be nonadhesive, able to be easily removed without trauma, accelerate the wound healing process, and deliver a nearly instantaneous initial dosage of drugs at optimum therapeutic concentrations. 7,8 Natural materials extensively used to fabricate wound dressings include collagen, 9 chitosan, 10 silk fibroin, 11 alginate, 12 and hyaluronic acid. 13 In several studies, such synthetic polymers as polylactic acid, 14 polycaprolactone, 15 polyethylene glycol, 16 polyvinyl alcohol, 17 and poly hydroxyl butyrate (PHB) 18 have been used to fabricate wound dressings.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Heydari

Varshosaz

Kharazi

et al. 2018

Polymers for Advanced Techs

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Biodegradable wound dressing of poly glycerol sebacate/poly hydroxy butyrate was fabricated via the coaxial electrospinning process. Simvastatin and ciprofloxacin were loaded in the core and shell of the fibers, respectively. Scanning electron microscopy and transmission electron microscopy images showed a uniform core/shell structure. Introducing drugs into the polymers would cause the dressing samples to become more hydrophilic and degradation to occur faster. Drugs release would face no interventions, in which, approximately 60% of ciprofloxacin was released during the first 24 hours. Simvastatin exhibited a slower and controlled release behavior, with its release peak recorded after 2 days. The drug‐containing samples showed a proper bactericidal activity against both Gram‐positive and Gram‐negative bacteria. It may be concluded that the drug‐laden wound dressing fabricated in this study is capable of releasing the 2 drugs sequentially and that it is the ideal conditions for controlling infections and reducing wound healing duration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Heydari

Varshosaz

Kharazi

et al. 2018

Polymers for Advanced Techs

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show abstract

“…W badaniach in vivo Ju i współpr. zastosowali nanowłók ninę fibroinową na ranę oparzeniową [28]. Wyniki gojenia się rany były porównywane z efektywnością działania na rany oparzeniowe pianki o nazwie handlowej Medifoam (hydrokomórkowa pianka do opatrunków).…”

Section: Materiały Opatrunkoweunclassified

Electrospun polymer nanofibers for medical applications

Winkler¹,

Maliszewska²,

Czapka³

2020

Polimery

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Streszczenie: Nanowłókna polimerowe wzbudzają obecnie ogromne zainteresowanie ze względu na ich potencjalne wykorzystanie w różnych procesach technologicznych, np. w produkcji tkanin lub wy twarzaniu membran. Włókna te wykazują wyjątkowe właściwości, takie jak: duży stosunek powierzch ni do objętości oraz duża porowatość. Znanych jest kilka metod wytwarzania nanowłókien, jednak ze względu na prostotę, powtarzalność i niewielkie koszty, najpowszechniej stosowane jest przędzenie elektrostatyczne. Przedstawiono przegląd najnowszych osiągnięć w zakresie zastosowań nanowłókien polimerowych w medycynie, obejmujący zagadnienia materiałów opatrunkowych, uwalniania sub stancji aktywnych oraz inżynierii tkankowej.Słowa kluczowe: elektroprzędzenie, nanowłókna, zastosowania medyczne.Abstract: Polymer nanofibers are currently of great interest in terms of their potential use in various technological processes, e.g. in the manufacture of textiles or membranes. These fibers are characterized by extraordinary properties such as high surface to volume ratio and high porosity. There are several methods of manufacturing nanofibers, but for reasons of simplicity, repeatability and low cost, elec trostatic spinning is the most common. The article presents a review of the latest developments in the application of polymer nanofibers in medicine, including such issues as bandage materials, release of active substances and tissue engineering.

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“…A recent study by Ju et al [36] reported fabrication of SF nanomatrix by electrospinning and evaluated as wound dressing material in a burn rat model. In brief, the SF solution was mixed with polyethylene oxide (PEO) to obtain desirable viscosity and spinnability.…”

Section: Natural Polymer Nanofibers As Wound Healing Scaffoldsmentioning

confidence: 99%