Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Abstract

Biodegradable wound dressing of poly glycerol sebacate/poly hydroxy butyrate was fabricated via the coaxial electrospinning process. Simvastatin and ciprofloxacin were loaded in the core and shell of the fibers, respectively. Scanning electron microscopy and transmission electron microscopy images showed a uniform core/shell structure. Introducing drugs into the polymers would cause the dressing samples to become more hydrophilic and degradation to occur faster. Drugs release would face no interventions, in which, approximately 60% of ciprofloxacin was released during the first 24 hours. Simvastatin exhibited a slower and controlled release behavior, with its release peak recorded after 2 days. The drug‐containing samples showed a proper bactericidal activity against both Gram‐positive and Gram‐negative bacteria. It may be concluded that the drug‐laden wound dressing fabricated in this study is capable of releasing the 2 drugs sequentially and that it is the ideal conditions for controlling infections and reducing wound healing duration.

The Development and Bio-applications of Multifluid Electrospinning

“…Biocompatibility and antibacterial properties are key for effective wound dressings. Various antibacterial materials have been applied using electrospun nanofibers to generate wound dressing materials, such as Ag Nanoparticles (AgNPs) [114,115], honey [116], vitamin E [117], broad-spectrum antimicrobial (such as trimethoxysilylpropyl octadecyldimethyl ammonium chloride (QAS), ciprofloxacin, tetracycline hydrochloride and simvastatin) [118][119][120], peptides [121] and so on. However, the majority of studies have been undertaken using single-fluid electrospinning, which is problematic for fibers from single-fluid electrospinning cannot draw drug release profiles very well compared with multifluid electrospinning.…”

“…Kalwar et al [122] prepared a core-shell fiber membrane comprising PCL@chitosan nanofibers incorporating AgNPs, and found them to have good antibacterial properties. By using coaxial electrospinning, Heydari et al [119] obtained an antibacterial and healing promotion coreshell membranes by loading simvastatin in the core and ciprofloxacin in the shell. Wen et al [123] also prepared a dual-functional core-shell electrospun mat with the ability to accurately control the release of anti-inflammatory and anti-bacterial agents.…”

Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers

“…Electrospun fiber mats have high surface area to volume ratios, high levels of porosity, and can incorporate high loadings of a functional component; this gives them applications in a number of fields including water filtration, catalysis, sensing, biomedical applications and drug delivery (Wang and Windbergs, 2011;Frenot and Chronakis, 2013;Ramakrishna et al, 2006;Bhardwaj and Kundu, 2010;Ahmed et al, 2015;Yu et al, 2013;Li et al, 2017;Kaassis et al, 2014;Quan et al, 2013;Tort et al, 2017;Kamble et al, 2017). While in the simplest experiment only a single solution is processed, resulting in monolithic fibers, it is also possible to work with multiple solutions at the same time, giving materials with core/shell or other nanoscale architectures (Heydari et al, 2018;Zhao et al, 4 2005; Yang et al, 2017). Scale up of the process is also possible (Démuth et al, 2016).…”

Rapid hemostasis by nanofibers of polyhydroxyethyl methacrylate/polyglycerol sebacic acid: An in vitro / in vivo study

“…In Giri Dev et al 86 the contact angle reported for PCL fibers was 103 while for the PCL/starch fibers it was 113 . The contact angle of PGS/polyhydroxybutyrate nanofibers was 53.2 according to Heydari et al 87 These results show the role of PHEMA and its capability in producing hydrogen bonds with water as an ideal hemostatic bandage.…”