Rapid hemostasis by nanofibers of polyhydroxyethyl methacrylate/polyglycerol sebacic acid: An in vitro <i>/</i> in vivo study

Varshosaz, Jaleh; Choopannejad, Zahra; Minaiyan, Mohsen; Kharazi, Anousheh Zargar

doi:10.1002/app.49785

Cited by 12 publications

(12 citation statements)

References 101 publications

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“…In contrast, the APTT values of Dia, ADia, CS/SA, and CS/SA/ADia sponges are much lower than that of fresh blood (Figure 6(b) and S4B), indicating that the hemostatic effect of composite sponge works through an intrinsic pathway 32,33 . The blood cells absorption and activation are important factors for hemostasis 34–37 . It has been reported that Dia participates in intrinsic pathway through the surface silanols 13 …”

Section: Resultsmentioning

confidence: 95%

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Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis

Guan

et al. 2021

J of Applied Polymer Sci

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Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3-Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross-linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA-based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency.

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Section: Resultsmentioning

confidence: 95%

“…32,33 The blood cells absorption and activation are important factors for hemostasis. [34][35][36][37] It has been reported that Dia participates in intrinsic pathway through the surface silanols. 13 Then, the fresh blood is co-cultured with the gelatin sponge, CS/SA sponge, and CS/SA/ADia30 for 5 min, respectively.…”

Section: Hemostatic Performancementioning

confidence: 99%

Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis

Guan

et al. 2021

J of Applied Polymer Sci

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“…This is achieved by concentrating the anticoagulant factors and tangible elements, such as platelets and RBCs, which enhances the rapid clotting of blood [ 43 , 44 ]. Fluid uptake depends on the hydrophilicity of the used polymer and porosity of the dressing matrix [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Hemostatic Alginate/Nano-Hydroxyapatite Composite Aerogel Loaded with Tranexamic Acid for the Potential Protection against Alveolar Osteitis

2022

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Wound control in patients on anticoagulants is challenging and often leads to poor hemostasis. They have a higher tendency to develop alveolar osteitis after tooth extraction. The application of a hemostatic dressing that has a high absorbing capacity and is loaded with an antifibrinolytic drug could help in controlling the bleeding. Alginate/nano-hydroxyapatite (SA/Nano-HA) composite aerogels loaded with tranexamic acid (TXA) were prepared. Nano-HA served as a reinforcing material for the alginate matrix and a source of calcium ions that helps in blood clotting. It influenced the porosity and the water uptake capacity. TXA release from SA/Nano-HA aerogels showed a biphasic profile for up to 4 h. Blood coagulation studies were performed on human whole blood. The TXA-loaded aerogel significantly reduced the clotting time by 69% compared to the control (p < 0.0001). Recalcification time was significantly reduced by 80% (p < 0.0001). Scanning electron microscopy analysis revealed the porous nature of the aerogels and the ability of the optimum aerogel to activate and adhere platelets to its porous surface. The cell migration assay showed that there was a delay in wound healing caused by the TXA aerogel compared to the control sample after treating human fibroblasts. Results suggest that the developed aerogel is a promising dressing that will help in hemostasis after tooth extraction.

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“…Electrospun nanofiber membranes can also be used as drug carriers to load anesthetics, antibacterial agents, bioactive molecules, etc., depending on different types of skin wounds (e.g., burns, trauma, chronic disease ulcers, etc.) [ 52 , 53 ]. It is made to function while controlling the release of drugs and promoting the wound healing process [ 54 , 55 ].…”

Section: Electrospinning Technologymentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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Rapid hemostasis by nanofibers of polyhydroxyethyl methacrylate/polyglycerol sebacic acid: An in vitro / in vivo study

Cited by 12 publications

References 101 publications

Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis

Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis

Hemostatic Alginate/Nano-Hydroxyapatite Composite Aerogel Loaded with Tranexamic Acid for the Potential Protection against Alveolar Osteitis

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

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