Facile fabrication of diatomite‐based sponge with high biocompatibility and rapid hemostasis

Abstract

Excessive bleeding causes a large part of deaths in wars and accidents. It is necessary to prepare a hemostatic material with excellent performance and low cost through a facile strategy. Herein, the diatomite is modified with (3-Aminopropyl) triethoxysilane (APTES) to endow the aminated diatomite (ADia) with positive charge and interface compatibility with chitosan (CS) and sodium alginate (SA). Then, the facile fabrication of CS/SA/ADia sponge is successfully obtained by cross-linking with calcium ions. Compared to CS/SA sponge, the introduction of ADia further enhances the mechanical properties and hemostatic performance of CS/SA-based sponges. The composite sponges with 30 wt% ADia are demonstrated to possess high biocompatibility, compressive strength, water adsorption, and rapid hemostatic capability both in vitro and in vivo. The hemostatic performance is interpreted by activation of coagulation factors and platelets in intrinsic pathway, promotion of blood cell adhesion and formation of fibrin network. Our work provides an effective strategy to develop rapid hemostatic materials with low cost and high efficiency.

Enhancement of fire safety in epoxy resin composites through incorporation of microencapsulated diatomite

“…7,8 These properties have enabled its widespread utilization as a reinforcement filler, separation material, adsorbent precursor, and filtration agent. 9,10 Recent attention has been directed towards DIA as a flame retardant in polymer composites, owing to its remarkable thermal stability. In a study by Cavodeau et al, 11 the incorporation of DIA and aluminum hydroxide as co-fillers was shown to enhance the flame retardancy of ethylene-vinyl acetate composites.…”

“…Diatomite (DIA), a natural porous material originating from diatoms, is primarily composed of SiO 2 and boasts a high surface area, unique pore structure, non‐toxicity nature, and abundant availability 7,8 . These properties have enabled its widespread utilization as a reinforcement filler, separation material, adsorbent precursor, and filtration agent 9,10 . Recent attention has been directed towards DIA as a flame retardant in polymer composites, owing to its remarkable thermal stability.…”

Template-free method synthesized NaxCa2.38-xAl2Si57.2O118.59 zeolite particles for enhanced stability

“…The strength of the organic-inorganic interactions is relatively fragile in the microemulsion con ned space that makes it di cult to achieve a stable preparation process under high temperature conditions. In fact, it is di cult to obtain an economical and easy to handle large-scale synthesis method for zeolite particles in actual hemostatic emergency engineering [33][34][35][36][37].…”